ACR Meeting Abstracts

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Abstracts tagged "interferons"

  • Abstract Number: 1015 • 2015 ACR/ARHP Annual Meeting

    Contribution of TNF and Type I Interferon to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice

    Sarah Woller1, Cody Ocheltree2, Tony Yaksh1 and Maripat Corr2, 1Anesthesiology, UCSD, La Jolla, CA, 2Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA

    Background/Purpose: Male C57Bl/6 (WT) mice develop transient inflammation in response to K/BxN serum transfer and show a corresponding pain state, which persists beyond the resolution…
  • Abstract Number: 1021 • 2015 ACR/ARHP Annual Meeting

    Nucleic Acids Sensing Receptors RIG-I and MDA5 As Potential Amplifiers of the Interferon Signature in Childhood Onset Systemic Lupus Erythematosus

    Naomi I Maria1, M. Javad Wahadat1, Cornelia G. van Helden-Meeuwsen1, Annette van Dijk-Hummelman2, Radboud JEM Dolhain3, Sylvia Kamphuis2 and Marjan A. Versnel1, 1Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 2Pediatric Rheumatology, Eramus MC Sophia Children's Hospital, Rotterdam, Netherlands, 3Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Defective or sustained activation of Interferon (IFN) signaling has been associated with enhanced susceptibility to systemic lupus erythematosus (SLE). The cytosolic RIG-I-like receptors (RLRs),…
  • Abstract Number: 1098 • 2015 ACR/ARHP Annual Meeting

    Interleukin-1 Reciprocally Regulates Interferon-Gamma Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) and Interleukin-6 in Human Synovial Fibroblasts

    Georg Pongratz1, Rainer Straub2 and Torsten Lowin3, 1Rheumatology - Hiller Research Center Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany, 2Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany, 3Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: B cell activating factor of the tumor necrosis factor family (BAFF) and interleukin-6 (IL-6) are cytokines important for the stimulation and survival of autoreactive…
  • Abstract Number: 1251 • 2015 ACR/ARHP Annual Meeting

    Physiological Evidence for Diversification of the IFNα- or IFNβ-Mediated Response Programs in Different Autoimmune Diseases

    Tamarah D. de Jong1, Saskia Vosslamber1, Elise Mantel1, Sander de Ridder1, John G. Wesseling1, Tineke C.T.M. van der Pouw Kraan2, Joep Killestein3, Ingrid E. Lundberg4, Jiri Vencovsky5,6, Irene E.M. Bultink7, Alexandre E. Voskuyl8, Michiel Pegtel1, Conny J. van der Laken9, Johannes W. Bijlsma8 and Cornelis L. Verweij1, 1Pathology, VU University medical center, Amsterdam, Netherlands, 2Molecular Cell Biology and Immunology, VU University medical center, Amsterdam, Netherlands, 3Neurology, VU University medical center, Amsterdam, Netherlands, 4Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 5Rheumatology, Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 7Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, 8Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, 9Rheumatology, VU University medical center, Amsterdam, Netherlands

    Background/Purpose: Presence of a type I interferon (IFN) signature is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM)…
  • Abstract Number: 1525 • 2015 ACR/ARHP Annual Meeting

    Detection of Previous Tuberculosis Infections in Japanese Rheumatoid Arthritis Patients: Comparison of Two Interferon-G Releasing Assays and the Impact of CD4-Positive Lymphocytes

    Shogo Banno1, Shiho Iwagaitsu2, Taio Naniwa3, Hironobu Nobata4, Hirokazu Imai4, Shinya Tamechika2, Shinji Maeda2 and Akio Niimi2, 1Rheumatology and Nephrology, Aichi Medical University School of Medicine, Aichi-prefecture, Japan, 2Allergy, Respiratory Medicine and Immunology, Nagoya City University Graduate School of Medical Science, Nagoya City, Japan, 3Allergy, Respiratory Medicine and Immunology, Nagoya City University Graduate School of Medical Science, Nagoya city, Japan, 4Rheumatology and Nephrology, Aichi Medical University School of Medicine, Nagakute City, Japan

    Background/Purpose: We aimed to evaluate the performance of QFT-GIT and T-SPOT.TB assays to predict the risk of latent tuberculosis infection (LTBI) in Japanese rheumatoid arthritis…
  • Abstract Number: 1805 • 2015 ACR/ARHP Annual Meeting

    Functional and Mechanistic Characterization of Anifrolumab, a Fully Human, Anti-IFNAR1 Monoclonal Antibody for the Treatment of Systemic Lupus Erythematosus

    Jeffrey Riggs1, Brian Naiman2, Jing Zhang1, Yan Xu1, Inna Vainshtein3, Carl Hay1, Kevin Schifferli1, Pina Cardarelli4, Meina Liang5, Lorin Roskos6, Jane Connor7, Roland Kolbeck8, Anthony Coyle9 and Michael Fung1, 1MedImmune LLC, Gaithersburg, MD, 2Research, MedImmune LLC, Gaithersburg, MD, 3MedImmune LLC, Hayward, CA, 4Medarex, Sunnyvale, CA, 5PKPD&Bioanalysis, MedImmune LLC, Hayward, CA, 6MedImmune LLC, Mountain View, CA, 7Respiratory, Inflammation and Autoimmunity (RIA), MedImmune LLC, Gaithersburg, MD, 8Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, 9Centers for Therapeutic Innovation, Pfizer, Inc. (formerly MedImmune LLC, Gaithersburg, MD, USA), Cambridge, MA

    Background/Purpose: Increased type I interferon (IFN) activities are associated with the pathogenesis of systemic lupus erythematosus (SLE). Anifrolumab, a fully human, IgG1 κ monoclonal antibody…
  • Abstract Number: 1828 • 2015 ACR/ARHP Annual Meeting

    Target Modulation of a Type I Interferon Gene Signature and Pharmacokinetics of Anifrolumab in a Phase IIb Study of Patients with Moderate to Severe Systemic Lupus Erythematosus

    Philip Brohawn1, Lingning Santiago2, Chris Morehouse1, Brandon Higgs1, Gabor Illei1 and Koustubh Ranade1, 1MedImmune, Gaithersburg, MD, 2MedImmune, Mountain View, CA

    Background/Purpose: Anifrolumab is a fully human IgG1 monoclonal antibody directed against subunit 1 of the type I interferon receptor (IFNAR1). Anifrolumab blocks the binding of…
  • Abstract Number: 2072 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial Reactive Oxygen Species Modulate Autoimmunity in Systemic Lupus Erythematosus

    Luz P. Blanco1, Christian Lood2, Monica Purmalek3, Suk See DeRavin4, Carolyne K. Smith3, Carmelo Carmona-Rivera3, Harry Malech4, Jeffrey Ledbetter5, Keith B. Elkon6 and Mariana J. Kaplan1, 1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Internal Medicine, University of Washington, Seattle, WA, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4NIAID/NIH, Bethesda, MD, 5University of Washington, Seattle, WA, 6Department of Medicine & Immunology, University of Washington, Seattle, WA

    Background/Purpose: Dysregulation in the formation of neutrophil extracellular traps (NETs) may contribute to modification and externalization of autoantigens and to organ damage in diverse autoimmune…
  • Abstract Number: 2073 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial ROS Is a Novel Regulator of Sting-Mediated Type I IFN Production By Governing Extrusion of Oxidized Mitochondrial DNA upon Neutrophil Extracellular Trap Formation.

    Christian Lood1, Luz P. Blanco2, Monica Purmalek3, Carolyne K. Smith3, Carmelo Carmona-Rivera3, Jeffrey Ledbetter4, Mariana J. Kaplan2 and Keith B. Elkon5, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Washington, Seattle, WA, 5Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil extracellular trap generation (NETosis) is a reactive oxygen species (ROS)-dependent cell death pathway implicated in autoimmune disorders such as systemic lupus erythematosus (SLE).…
  • Abstract Number: 2433 • 2015 ACR/ARHP Annual Meeting

    Anti Interferon-Gamma (IFNg) Monoclonal Antibody Treatment in a Child with NLRC4-Related Disease and Severe Hemophagocytic Lymphohistiocytosis (HLH)

    Claudia Bracaglia1, Giusi Prencipe1, Antonio Gatto2, Manuela Pardeo1, Geneviève Lapeyre3, Luigi Raganelli1, Emiliano Marasco2, Antonella Insalaco2, Walter Ferlin3, Robert Nelson3, Cristina de Min3 and Fabrizio De Benedetti1, 1Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, 2Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, 3NovImmune S.A., Geneva, Switzerland

    Background/Purpose: Animal and humans data suggest that IFNγ plays a pathogenic role in HLH. A pilot trial in primary HLH with NI-0501, an anti-IFNγ monoclonal…
  • Abstract Number: 2471 • 2015 ACR/ARHP Annual Meeting

    Increased Muscle Interferon-Gamma Expression Levels in Juvenile Dermatomyositis

    Gian Marco Moneta1, Adele D'Amico2, Margherita Verardo3, Denise Pires Marafon4, Luisa Bracci Laudiero5, Fabrizio De Benedetti6 and Rebecca Nicolai7, 1Department Pediatric Medicine, Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy, 2Department of Neuroscience,, Unit of Neuromuscular and Neurodegenrative Disease, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy, 3Department of Neuroscience, Unit of Neuromuscular and Neurodegenrative Disease, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy, 4Pediatric Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 5Rheumatology Laboratory, Bambino Gesú Children Hospital, Rome, Italy, 6Pediatric Rheumatology, Bambino Gesù Children's Hospital, Rome, Italy, 7Department of Pediatric Medicine, Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

    Background/Purpose : Juvenile dermatomyositis (JDM) is a rare autoimmune disorder characterized by muscle weakness, skin rashes and other systemic features. The immunopathogenesis of JDM is…
  • Abstract Number: 721 • 2015 ACR/ARHP Annual Meeting

    Geographic Differences in Demographics, Clinical Characteristics, and Standard of Care in Multinational Studies of Patients with Moderate to Severe Systemic Lupus Erythematosus

    Richard Furie1, M Khamashta2, L Wang3, J Drappa3, W Greth3 and G Illei3, 1Division of Rheumatology, North Shore - LIJ Health System, New York, NY, 2Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, 3MedImmune, Gaithersburg, MD

    Background/Purpose: Most randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) include stratification factors to ensure a balanced allocation of subgroups that might respond differently…
  • Abstract Number: 2512 • 2015 ACR/ARHP Annual Meeting

    Depot Medroxyprogesterone Acetate Birth Control May Suppress Toll-like Receptor 7-Induced Interferon-Alpha Production By Plasmacytoid Dendritic Cells in Women

    Yuli McCann1, Meredith Barnes1 and Grant Hughes2, 1Medicine, University of Washington, Seattle, WA, 2Medicine/Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Female sex steroids are important modulators of autoimmunity.  Estrogen appears to favor the development of lupus autoimmunity via activation of adaptive and innate immune…
  • Abstract Number: 801 • 2015 ACR/ARHP Annual Meeting

    Artesunate Modulates Atherosclerosis Related Factors through the Inhibition of STAT1

    Xuebing Feng1, Weiwei Chen2, Lihui Xiao1 and Lingyun Sun2, 1Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 2Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

    Background/Purpose: While type I interferon (IFN) has been linked to atherosclerosis progression in systemic lupus erythematosus (SLE), little is known about its regulation and intervention.…
  • Abstract Number: 2934 • 2015 ACR/ARHP Annual Meeting

    Endothelial Dysfunction in SLE-the Role of Platelets and Type I Interferon

    Helena Tydén1, Christian Lood2, Birgitta Gullstrand3, Andreas Jönsen4 and Anders A. Bengtsson5, 1Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 2Department of Clinical Sciences, Division of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 3Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital, Lund University, Lund, Sweden, 4Department of Rheumatology, Lund University Hospital, Lund, Sweden, 5Rheumatology, Inst of Clinical sciences, Lund, Sweden

    Background/Purpose: Type I interferon (IFN) may affect endothelial progenitor cells leading to endothelial dysfunction in SLE. SLE patients have a type I IFN signature in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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