ACR Meeting Abstracts

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Abstracts tagged "interferons"

  • Abstract Number: 864 • 2016 ACR/ARHP Annual Meeting

    Takayasu Arteritis Developed over the Age of 40 Has Lower Levels of Interferon Gamma and Interleukin 17 at Disease Onset and Fewer Subsequent Relapses

    Shoichi Fukui1, Naoki Iwamoto2, Toshimasa Shimizu2, Masataka Umeda2, Ayako Nishino3, Yoshiro Horai2, Tomohiro Koga4, Shin-ya Kawashiri5, Kunihiro Ichinose1, Yasuko Hirai2, Mami Tamai1, Hideki Nakamura5, Tomoki Origuchi6, Kiyoshi Migita7, Yukitaka Ueki8 and Atsushi Kawakami9, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 3Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki Universit, Nagasaki, Japan, 4Unit of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 6Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, 7Department of Rheumatology and Clinical Research Center, Nagasaki Medical Center, Omura, Japan, 8Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Japan, 9Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Background/Purpose: The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis (TAK) include age at disease onset ≤ 40 years. We aimed…
  • Abstract Number: 1518 • 2016 ACR/ARHP Annual Meeting

    Immunoglobulin Binding Protein (BiP), an Antigen for CCP Sero-Positive Rheumatoid Arthritis Patients, Can Result in a False Positive Quantiferon-Gold Tuberculosis Test

    JoAnn Ball1, Kelsy Greenwald1, Atul A. Deodhar2 and Kevin L. Winthrop3, 1Rheumatology, Desert Medical Advances, Palm Desert, CA, 2Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, 3Oregon Health and Sciences University, Portland, OR

    Background/Purpose: Citrullinated BiP is a newly described target for cyclic citrullinated peptide(CCP).  BiP in both serum and synovial fluid is over-expressed in RA patients and…
  • Abstract Number: 1831 • 2016 ACR/ARHP Annual Meeting

    A Novel Graph Theoretic Approach Applied to Modular Repertoire Analysis Identifies a Dual Molecular Progression in Adult SLE Patients, with Distinct Interferon and Neutrophil Transcription Patterns

    Ilya Korsunski1, Noémie Jourde-Chiche2,3, Peter K. Gregersen1, Damien Chaussabel4, Laurent Chiche5 and Naomi I Maria6, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, 3Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, 4Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 5internal medicine, Hopital Europeen, Marseille, France, 6Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose:  Gene expression studies support a pivotal role for type I interferon (IFN) in SLE. Previous work using a modular repertoire analysis based on co-clustered…
  • Abstract Number: 1832 • 2016 ACR/ARHP Annual Meeting

    Increased Interferon b Expression in Bone Marrow Mediates a Senescent Phenotype and Impaired Production of Immunomodulatory Factors By SLE Mesenchymal Stromal Cells

    Lin Gao1, Jennifer H. Anolik2 and R. John Looney2, 1medicine- allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Bone marrow mesenchymal stromal cells (MSCs) are multipotent stem cells that create a special microenvironment for hematopoiesis and immunity. MSCs display robust immunomodulatory properties…
  • Abstract Number: 2009 • 2016 ACR/ARHP Annual Meeting

    The Effect of Anifrolumab on Cutaneous Manifestations and Arthritis in Moderate to Severe Systemic Lupus Erythematosus (SLE) Using Categorical SLEDAI–2K Responses and Continuous Measures of Activity As Outcome Measures

    JT Merrill1, R Furie2, Victoria P. Werth3,4, M Khamashta5, J Drappa6, L Wang6 and G Illei6, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Northwell Health, Great Neck, NY, 3University of Pennsylvania, Philadelphia, PA, 4Philadelphia V.A. Medical Center, Philidelphia, PA, 5Graham Hughes Lupus Research Laboratory, London, United Kingdom, 6MedImmune, Gaithersburg, MD

    Background/Purpose: The Phase IIb MUSE study (NCT01438489) of intravenous anifrolumab in 305 patients with moderate to severely active SLE (300 or 1,000 mg vs. placebo,…
  • Abstract Number: 2057 • 2016 ACR/ARHP Annual Meeting

    TLR-7-Mediated Lupus Nephritis Flares Are Independent of Type I Interferon Signaling

    Sonya Wolf1, Tamra J. Reed2, Chaim O. Jacob3 and J. Michelle Kahlenberg4, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 2Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, 3Medicine/Div of Rheumatology, USC School of Medicine, Los Angeles, CA, 4Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the formation of autoantibodies, immune complex deposition, elevated production of type I interferons (IFNs),…
  • Abstract Number: 2087 • 2016 ACR/ARHP Annual Meeting

    A Type I Interferon Signature in Monocytes and Decreased Levels of Circulating Plasmacytoid Dendritic Cells in Patients with Primary Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Ruth D.E. Fritsch-Stork2, Marjan A. Versnel3, Ronald H.W.M. Derksen4, Joel A.G. van Roon5,6 and Timothy R.D.J. Radstake5,6, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 4Departments of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 6Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands

    Background/Purpose: In several autoimmune diseases, most notably in systemic lupus erythematosus (SLE), a type I interferon (IFN) signature has been described. This signature is thought…
  • Abstract Number: 2431 • 2016 ACR/ARHP Annual Meeting

    Characterization of Innate Immune Cells in Patients with the Interferon-Mediated Autoinflammatory Diseases Sting Associated Vasculopathy with Onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE)

    Bernadette Marrero1, Yin Liu2, Katherine R. Calvo3, Angelique Biancotto4, Yan Huang1, Adriana Almeida de Jesus1, Gina A. Montealegre Sanchez1 and Raphaela Goldbach-Mansky5, 1National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 2Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 3Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, 4Center for Human Immunology, Autoimmunity and Inflammation, NHLBI/NIH, Bethesda, MD, 5Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD

    Background/Purpose:   We recently described two rare autoinflammatory interferonopathies, STING Associated Vasculopathy with Onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and…
  • Abstract Number: 2565 • 2016 ACR/ARHP Annual Meeting

    Common Biomarker Elevations in Idiopathic Pulmonary Fibrosis and Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Karen Fernandez1, Tracy Doyle2, Lisa Harlow3, Ivan O. Rosas4 and Dana P. Ascherman5, 1Rheumatology, University of Miami Miller School of Medicine, Miami, FL, 2Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 3Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, 4BWH - Pulmonary, Brigham and Women's Hospital, Boston, MA, 5Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL

    Background/Purpose:  Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) which contributes to increased morbidity and mortality. Clinico-epidemiological data indicate some overlap…
  • Abstract Number: 2810 • 2016 ACR/ARHP Annual Meeting

    Correlates of Spontaneous Cytokine Production in Individuals Undergoing Interferon-Gamma Release Assay Testing

    Grant Hughes1, Christian Lood2, Uche Obih1 and David Koelle1, 1University of Washington, Seattle, WA, 2Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: The interferon gamma (IFN-G) release assay (IGRA) estimates probability of latent TB infection (LTBI) based on IFN-G released by whole blood after 18h exposure…
  • Abstract Number: 2878 • 2016 ACR/ARHP Annual Meeting

    Major Lymphocyte Populations Share a Common Interferon Signature but Express Cell Type-Specific Interferon Pathway Genes in SLE

    Mikhail Olferiev1, Kyriakos A. Kirou2, David Fernandez3, Khalili Leila1, Dina Greenman1 and Mary K. Crow4, 1Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Rheumatology, New York Presbyterian - Cornell Campus - HSS, New York, NY, 4Department of Medicine, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY

    Background/Purpose: All lymphocyte populations contribute to SLE pathogenesis, but little is known of the specific gene transcripts particularly involved in each cell type. Activation of…
  • Abstract Number: 807 • 2015 ACR/ARHP Annual Meeting

    High Levels of Serum IFN-Alpha Mark a Subgroup of SLE Patients with Distinct Immunophenotypic Features and Hyperresponsiveness to Toll-like Receptor Stimulation

    Uma Thanarajasingam1, Mark A. Jensen2, Jessica M. Dorschner3 and Timothy B. Niewold3, 1Division of Rheumatology, Mayo Clinic, Rochester, MN, 2Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN

    Background/Purpose: IFN-alpha is a pathogenic factor in SLE.  High serum interferon activity (IFN-high) marks a subgroup of SLE patients strongly associated with increased disease severity…
  • Abstract Number: 3223 • 2015 ACR/ARHP Annual Meeting

    Anifrolumab, an Anti-Interferon Alpha Receptor Monoclonal Antibody, in Moderate to Severe Systemic Lupus Erythematosus (SLE)

    Richard Furie1, JT Merrill2, VP Werth3,4, M Khamashta5, K Kalunian6, P Brohawn7, G Illei7, J Drappa7, L Wang7 and S Yoo8, 1North Shore-LIJ Health System, New York, NY, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Philadelphia V.A. Medical Center, Philidelphia, PA, 4University of Pennsylvania, Philadelphia, PA, 5Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, 6UCSD School of Medicine, La Jolla, CA, 7MedImmune, Gaithersburg, MD, 8Regenx Bio, Rockville, MD

    Background/Purpose: The efficacy and safety of anifrolumab (ANIFR), a type I IFN receptor antagonist, were assessed in a Phase II, randomized, double-blind, placebo-controlled study in…
  • Abstract Number: 992 • 2015 ACR/ARHP Annual Meeting

    Therapeutic Targeting of CD4+ T Cell Metabolism in Murine Models of Lupus

    Laurence Morel1, Seung-Chul Choi2, Zhiwei Xu2, Elisabeth Adkins3, Byron Croker2 and Derry Roopenian3, 1Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, 2University of Florida, Gainesville, FL, 3The Jackson Laboratory, Bar Harbor, ME

    Background/Purpose: Cellular metabolism controls T cell functions, with TCR-mediated activation enhancing metabolism, and substrate utilization modulating effector functions.  Autoreactive CD4 T cells are key effectors…
  • Abstract Number: 3259 • 2015 ACR/ARHP Annual Meeting

    Immunoablation Followed By Autologous Stem Cell Transplantation in Systemic Sclerosis Patients Decreases Significantly the Interferon Signatrue

    Shervin Assassi1, Maureen D Mayes1, Claudia Pedroza2, Jeffrey T. Chang2, Daniel E. Furst3, Leslie J. Crofford4, Richard Nash5, Peter McSweeney5, Mary Ellen Csuka6, Ellen Goldmuntz7, Lynette Keyes-Elstein8, Paul Wallace9 and Keith Sullivan10, 1Rheumatology, University of Texas Medical School at Houston, Houston, TX, 2University of Texas Medical School at Houston, Houston, TX, 3Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 4Medicine, Vanderbilt University, Nashville, TN, 5Colorado Blood Cancer Institute, Denver, CO, 6Rheum/Med Coll of Wisconsin, Med Coll of Wisconsin, Milwaukee, WI, 7NIAID, National Institutes of Health, Bethesda, MD, 8Rho Federal Systems, Inc., Chapel Hill, NC, 9Roswell Park, Buffalo, NY, 10Duke University, Durham, NC

    Background/Purpose: Previous clinical trials have suggested that immunoablation followed by autologous hematopoietic cell transplantation (HCT) can lead to clinical improvements in systemic sclerosis (SSc). However,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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