ACR Meeting Abstracts

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Abstracts tagged "interferons"

  • Abstract Number: 85 • 2017 ACR/ARHP Annual Meeting

    Enhanced IFN-γ STAT1 Signaling in CD4 T Cell Populations and Attenuated IL-2 STAT5 Signaling Contribute to the Pathogenesis of Rheumatoid Arthritis (RA)

    Brandon Pope1, Vishal Sharma2, Molly Boland2, Richard Reynolds2, S. Louis Bridges Jr.3 and Chander Raman4, 1Medicine, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, 4Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Type I (IFN-α) and type II (IFN-γ) interferons are important mediators of autoimmunity. However, there is conflicting evidence regarding the contribution of IFN-γ to…
  • Abstract Number: 860 • 2017 ACR/ARHP Annual Meeting

    Effective Treatment of Persistent Arthritis Pain Requires Co-Modulation of TNF and Type I Interferon

    Sarah Woller1, Tony Yaksh2 and Maripat Corr3, 1Anesthesiology, UCSD, La Jolla, CA, 2Anesthesiology 0818, UCSD, La Jolla, CA, 3Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA

    Background/Purpose: Pain persisting beyond the resolution or control of clinical signs of rheumatoid arthritis (RA) decreases quality of life for millions of people. Unfortunately, this…
  • Abstract Number: 866 • 2017 ACR/ARHP Annual Meeting

    Interferon-Alpha Overexpression Triggers an Expansion of Highly Suppressive Regulatory T Lymphocytes Protecting Against Experimental Arthritis

    Matthieu Ribon1,2, Katarzyna Matyja2,3, Roxane Hervé2,3, Delphine Lemeiter2,3, François Santinon2,3, Ken Tsumiyama4, Shunichi Shiozawa4, Marie-Christophe Boissier3,5,6, Natacha Bessis2,3 and Patrice Decker2,3, 1li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2UMR 1125, INSERM, Bobigny, France, 3Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 4Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, 5Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, 674 rue Marcel Cachin, INSERM, Bobigny, France

    Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
  • Abstract Number: 1656 • 2017 ACR/ARHP Annual Meeting

    Type I Interferon Drives the Dysregulation of Plasmacytoid and Myeloid Dendritic Cells in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Aridaman Pandit1, Giovanni Palla2, Marzia Rossato3, Ruth D.E. Fritsch-Stork4, Joel A.G. van Roon5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology and Clinical Immunology, Laboratory of Translational Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Dendritic cells (DC) are the sentinel cells of the immune system that potently activate T-cells, making them important players in the pathophysiology of systemic…
  • Abstract Number: 1663 • 2017 ACR/ARHP Annual Meeting

    De Novo Mutation in ΑCΑCΒ in Childhood Onset SLE Highlights a Novel Role As Modulator of Nucleic Acid Sensor-Driven Type I Interferon Responses

    Isaac Harley1, Hanna Schulz1, John Cambier2, Leah C. Kottyan3, John B. Harley4, V. Michael Holers5, Hermine I. Brunner6, Kristine Kuhn1, Kevin D. Deane1 and Kenneth Kaufman7, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Deparment of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO, 3Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, 6Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH

    Background/Purpose: Rare variants provide important opportunity for mechanistic insight as they carry substantial effect sizes and provide deep insight into disease etiopathogenesis. To date, several…
  • Abstract Number: 1719 • 2017 ACR/ARHP Annual Meeting

    Accelerated Wound Healing in Megakaryocyte/Platelet-Specific Fli1 Knockout Mice Due to the up-Regulated Expression of Interferon-γ

    Megumi Hirabayashi1, Yoshihide Asano2, Takashi Yamashita1, Ryosuke Saigusa1, Shunsuke Miura3, Kouki Nakamura1, Takuya Miyagawa1, Takashi Taniguchi1, Ayumi Yoshizaki1 and Shinichi Sato4, 1Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 2Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 3University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 4Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

    Background/Purpose: Fli1 deficiency, a potential predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in dermal fibroblasts, endothelial cells, keratinocytes, and macrophages. However, it is…
  • Abstract Number: 1893 • 2017 ACR/ARHP Annual Meeting

    Pharmacokinetics (PK), Pharmacodynamics (PD), and Proposed Dosing of Oral Janus Kinase (JAK)1 and JAK2 Inhibitor Baricitinib in Patients with IFN-Mediated Autoinflammatory Diseases (AIDs)

    Hanna Kim1, Kristina M. Brooks2, Paul Wakim3, Mary Blake4, Stephen R. Brooks5, Gina A. Montealegre Sanchez6, Adriana Almeida de Jesus6, Yan Huang6, Wanxia Li Tsai7, Massimo G. Gadina4, Parag Kumar2 and Raphaela Goldbach-Mansky6, 1Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, MD, 2Clinical Pharmacokinetics Research Unit, Pharmacy Department, NIH Clinical Center, Bethesda, MD, 3Biostatistics and Clinical Epidemiology Service, NIH Clinical Center, Bethesda, MD, 4Translational Immunology Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, 5Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, 6Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 7Translational Immunology, Office of Science and Technology, NIAMS/NIH, Bethesda, MD

    Background/Purpose: JAK inhibitors reduce IFN-signaling ex vivo. We evaluated the PK and PD of the oral JAK1 and JAK2 inhibitor, baricitinib, from data collected in…
  • Abstract Number: 2336 • 2017 ACR/ARHP Annual Meeting

    Expression of Myxovirus-Resistance Protein a: A Possible Marker of Muscular Disease Activity in Juvenile Dermatomyositis

    Sirisucha Soponkanaporn1, Claire Deakin2, Lucy Marshall2, Cerise Johnson2, Peter Schutz1 and Lucy R Wedderburn2, 1Infection Inflammation and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, 2Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom

    Background/Purpose: Juvenile dermatomyositis (JDM) is a chronic autoimmune myopathy characterized by proximal muscle weakness and typical skin rashes. Type I interferon (IFN) gene expression in…
  • Abstract Number: 2568 • 2017 ACR/ARHP Annual Meeting

    Prophylactic and Therapeutic Administration of a JAK1-Selective Inhibitor Blocks and Reverses Nephritis and Sialadenitis in NZB/W-F1 Mice

    Rachel Twomey1, Stuart Perper1, Susan Westmoreland1, Terry Melim1, Soumya Mitra1, Zheng Liu1, Manuel Duval1, Carolyn Cuff2, Andrew Long1, Anthony Slavin2 and Stephen Clarke1, 1AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, 2Immunology Discovery, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose: Signaling of most cytokine receptors occurs through the JAK-STAT pathway. This is true of cytokines linked to the etiology of systemic lupus erythematosus (SLE)…
  • Abstract Number: 2589 • 2017 ACR/ARHP Annual Meeting

    Functional and Mechanistic Characterization of Anifrolumab, a Fully Human Monoclonal Antibody Targeting the Interferon Alpha Receptor 1 for the Treatment of SLE

    Gary P. Sims1, Jeffrey Riggs2, Richard Hanna1, Bhargavi Rajan3, Jodi Karnell1, Kamelia Zerrouki1, Divya Sagar1, Inna Vainshtein3, Erika Farmer4, Meina Liang3, Miguel A. Sanjuan1 and Roland Kolbeck1, 1Respiratory, Inflammation and Autoimmunity (RIA), MedImmune, LLC, Gaithersburg, MD, 2Respiratory, Inflammation and Autoimmunity (RIA), MedImmune LLC, Gaithersburg, MD, 3MedImmune, LLC, Mountain View, CA, 4Analytical Sciences, MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: Increased type I interferon (IFN) activity is associated with the pathogenesis of SLE. Anifrolumab, a fully human immunoglobulin (Ig) G1 κ monoclonal antibody in clinical…
  • Abstract Number: 2431 • 2016 ACR/ARHP Annual Meeting

    Characterization of Innate Immune Cells in Patients with the Interferon-Mediated Autoinflammatory Diseases Sting Associated Vasculopathy with Onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE)

    Bernadette Marrero1, Yin Liu2, Katherine R. Calvo3, Angelique Biancotto4, Yan Huang1, Adriana Almeida de Jesus1, Gina A. Montealegre Sanchez1 and Raphaela Goldbach-Mansky5, 1National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 2Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 3Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, 4Center for Human Immunology, Autoimmunity and Inflammation, NHLBI/NIH, Bethesda, MD, 5Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD

    Background/Purpose:   We recently described two rare autoinflammatory interferonopathies, STING Associated Vasculopathy with Onset in Infancy (SAVI) and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and…
  • Abstract Number: 2565 • 2016 ACR/ARHP Annual Meeting

    Common Biomarker Elevations in Idiopathic Pulmonary Fibrosis and Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Karen Fernandez1, Tracy Doyle2, Lisa Harlow3, Ivan O. Rosas4 and Dana P. Ascherman5, 1Rheumatology, University of Miami Miller School of Medicine, Miami, FL, 2Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 3Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, 4BWH - Pulmonary, Brigham and Women's Hospital, Boston, MA, 5Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL

    Background/Purpose:  Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) which contributes to increased morbidity and mortality. Clinico-epidemiological data indicate some overlap…
  • Abstract Number: 2810 • 2016 ACR/ARHP Annual Meeting

    Correlates of Spontaneous Cytokine Production in Individuals Undergoing Interferon-Gamma Release Assay Testing

    Grant Hughes1, Christian Lood2, Uche Obih1 and David Koelle1, 1University of Washington, Seattle, WA, 2Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: The interferon gamma (IFN-G) release assay (IGRA) estimates probability of latent TB infection (LTBI) based on IFN-G released by whole blood after 18h exposure…
  • Abstract Number: 2878 • 2016 ACR/ARHP Annual Meeting

    Major Lymphocyte Populations Share a Common Interferon Signature but Express Cell Type-Specific Interferon Pathway Genes in SLE

    Mikhail Olferiev1, Kyriakos A. Kirou2, David Fernandez3, Khalili Leila1, Dina Greenman1 and Mary K. Crow4, 1Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Rheumatology, New York Presbyterian - Cornell Campus - HSS, New York, NY, 4Department of Medicine, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY

    Background/Purpose: All lymphocyte populations contribute to SLE pathogenesis, but little is known of the specific gene transcripts particularly involved in each cell type. Activation of…
  • Abstract Number: 3006 • 2016 ACR/ARHP Annual Meeting

    IFN-Gamma (IFNγ), IFNγ-Induced Chemokines and Other Biomarkers in Macrophage Activation Syndrome (MAS)

    Claudia Bracaglia1, Denise Pires Marafon2, Ivan Caiello2, Kathy de Graaf3, Florence Guilhot3, Walter Ferlin3, Sergio Davì4, Grant Schulert5, Angelo Ravelli4, Alexei Grom6, Robert Nelson3, Cristina de Min3 and Fabrizio De Benedetti1, 1Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Italy, 2Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy, 3NovImmune S.A., Geneva, Switzerland, 4Istituto Giannina Gaslini, Genoa, Italy, 5Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose:  Evidence in animals and humans points to a pivotal role of IFNγ in primary HLH. We have recently generated data in an animal model…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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