ACR Meeting Abstracts

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Abstracts tagged "interferons"

  • Abstract Number: 105 • 2018 ACR/ARHP Annual Meeting

    Immunologic Properties of Cutaneous Lupus Erythematosus (CLE) Patients Refractory to Antimalarials Compared to Patients That Respond to Antimalarials

    Majid Zeidi1,2, Krisha Desai3,4, Hee Joo Kim3,4,5 and Victoria P. Werth3,4, 1University of Pennsylvania, Philadelphia, PA, 2Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, 3Department of Dermatology, Corporal Michael J. Crescenz VAMC, Philadelphia, PA, 4Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Department of Dermatology, Gachon Gil Medical Center, School of Medicine, Gachon University, Incheon, Korea, Republic of (South)

    Background/Purpose: Two major therapies for cutaneous lupus erythematosus (CLE) are the antimalarials, hydroxychloroquine (HCQ) and quinacrine (QC). HCQ is often the first-line therapy for CLE,…
  • Abstract Number: 125 • 2018 ACR/ARHP Annual Meeting

    Monocyte Transcriptome Delineates SSc Patients with Functionally Distinct Patterns of Gene Dysregulation That Persist through Differentiation

    Julia L.M. Dunn1, Philip J. Homan2, Salina Dominguez1, Carla M. Cuda1, Kathleen Aren3, Mary A. Carns3,4, Tracy M. Frech5, Dinesh Khanna6, Shervin Assassi7, Harris Perlman1, Monique Hinchcliff1 and Deborah R. Winter1, 1Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 4Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Rheumatology, University of Utah, Salt Lake City, UT, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: The etiology and pathogenesis of SSc are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes, and may…
  • Abstract Number: 878 • 2018 ACR/ARHP Annual Meeting

    IFN Level Assessed By Ultrasensitive Detection Technology in Myositis Patient: A Promising Biomarker of Disease Activity in Dermatomyositis and Anti-Synthetase Syndrome

    Loïs BOLKO1,2, Ségolène Toquet3, Océane Landon-Cardinal4, Karim DORGHAM5, Celine Anquetil6, Darragh Duffy7, Nadège WESNER8, Damien Amelin9, Gaëlle DZANGUE TCHOUPOU2, Perrine Guillaume10, Aude Rigolet11, Baptiste Hervier11, Mathieu Vautier11, Nicolas Champtiaux11, Guy Gorochov12, Jean-Hugues Salmon13, Olivier Benveniste11 and Yves Allenbach14, 1Rheumatology, CHU Reims, Hôpital Maison Blanche, Reims, France, 2INSERM UMRS974, Pitié-Salpêtrière University Hospital, Paris, France, 3Médecine interne, CHU Reims, Robert debré, Reims, France, 4Rhumatologie, Hopital Notre-Dame Montréal, Montreal, QC, Canada, 5CIMI, INSERM, Paris, France, 6CDR en myologie UMR974,, Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, PARIS, France, 7Institut Pasteur, Paris, Paris, France, 8INSERM UMRS974, Pitié-Salpêtrière University Hospital, paris, France, 9Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, 10Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Universitaire Pitié Salpêtrière, paris, France, 11Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, 12CIMI, INSERM, paris, France, 13Service de Rhumatologie, CHU Reims, Hôpital Maison Blanche, Reims, France, 14Internal Medicine and Clinical Immunology, Sorbonne University - Assistance Public - Hopitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: Inflammatory idiopathic myopathies (IIM) is a heterogeneous group of disorders ranging from muscle specific auto-immune diseases to systemic ones (dermatomyositis (DM), anti-synthetase syndrome (ASS),…
  • Abstract Number: 1080 • 2018 ACR/ARHP Annual Meeting

    Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T Cells Is Associated with Type-I Interferon-Dependent HLA-DRB1 Overexpression and Activation of Autologous CD4+ T Cells in Systemic Lupus Erythematosus

    Shaylynn Miller1, Patrick Coit1, Elizabeth Gensterblum-Miller1, Paul Renauer1,2, Nathan Kilian1,3, Mark Schonfeld1, Pei-Suen Tsou1 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Department of Genetics, Yale University, New Haven, CT, 3Medical School, Georgetown University, Washington, DC

    Background/Purpose: Systemic lupus erythematosus is a chronic autoimmune disease characterized by epigenetic dysregulation, and increased autoantibody and type-I interferon (IFN) production. The goal of this…
  • Abstract Number: 1093 • 2018 ACR/ARHP Annual Meeting

    Serologic Evidence Linking Epstein Barr Virus Reactivation, Heightened Interferon Pathway Activation and Increased Disease Activity in Patients with Systemic Lupus Erythematosus

    Rebecca Wood1, Lauren Guthridge1, Carla J. Guthridge2, Rebecka L. Bourn1, Hua Chen1, Wade DeJager1, Susan R. Macwana1, Stan Kamp1, Rufei Lu1,3, Cristina Arriens1, Eliza Chakravarty1, Katherine Thanou1, Joan T. Merrill1, Joel M. Guthridge1,4 and Judith A. James4,5, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: SLE is a clinically heterogeneous disease oftentimes characterized by a waxing and waning course. Mechanisms of SLE flare remain elusive. This study examined relationships…
  • Abstract Number: 1096 • 2018 ACR/ARHP Annual Meeting

    Unexpected Association between Health-Related Quality of Life and the Blood Interferon Modular Transcriptional Signatures in Patients with Systemic Lupus Erythematosus

    Laurent Chiche1, julie seguier2, stephanie gentile2, stephane burtey2, bertrand dussol2, philippe halfon3, wahiba bidaut3, elisabeth jouve2 and Noémie Jourde-Chiche4, 1Internal medicine, Hopital europeen, Marseille, France, 2aphm, marseille, France, 3hopital europeen, marseille, France, 4Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France

    Background/Purpose: SLE has important effects on health-related quality of life (HRQOL) and is not well correlated to disease activity. As most SLE patients in remission…
  • Abstract Number: 1111 • 2018 ACR/ARHP Annual Meeting

    CBS004, a Novel Monoclonal Antibody Against Bdca-2 Inhibits TLR-Induced Activation of Human pDC in Vitro and In Vivo. a Novel Therapeutic Target for Systemic Sclerosis

    Clarissa Corinaldesi1, Yasser M El-Sherbiny2, Gemma Migneco3, Rebecca Ross1, Steve Holmes4, Clive McKimmie5 and Francesco Del Galdo1, 1Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, 3Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom, 4Capella Biosciences, LTD, London, United Kingdom, 5Virus Host Interactions Team, Section of Infection and Immunity, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
  • Abstract Number: 1348 • 2018 ACR/ARHP Annual Meeting

    Quantitative High Throughput Screening of Small Molecules to Inhibit Interferon-Stimulated Major Histocompatibility Complex Class I in Myositis Muscle

    Travis Kinder, Patricia Dranchak and James Inglese, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD

    Background/Purpose: Common molecular and histological features of idiopathic inflammatory myopathies (myositis) include activation of the type 1 interferon (IFN) response and aberrant expression of major…
  • Abstract Number: 1352 • 2018 ACR/ARHP Annual Meeting

    Low Density Granulocytes in Idiopathic Inflammatory Myopathy

    David Fernandez1, Linjia Jia2, Mikhail Olferiev3, Annel M. Fernandez4, JoAnn Vega5, Kerri Merritt6, Michael Lockshin7 and Peggy Crow1, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 3Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, 4Medicine- Rheumatology/ Research, Hospital for Special Surgery, New York, NY, 5Medicine - Rheumatology / Research, Hospital for Special Surgery, New York, NY, 6Hospital for Special Surgery, New York, NY, 7Barbara Volcker Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: Idiopathic Inflammatory Myopathy (IIM) is a group of autoimmune diseases characterized by immune-mediated injury to skeletal muscle, including polymyositis (PM) and dermatomyositis (DM). Recent…
  • Abstract Number: 2097 • 2018 ACR/ARHP Annual Meeting

    Monotherapy with Filgotinib, a JAK1-Selective Inhibitor, Reduces Disease Severity and Alters Immune Cell Subsets in the NZB/W F1 Murine Model of Lupus

    Pei Han1, Christopher Pohlmeyer1, Ching Shang1, Zhihua Cui2, David Lopez3, Astrid Clarke2, Randall Jones2, Nevena Mollova3, Igor Mikaelian4, David Newstrom3, Shiva Zaboli3, Allyson Shauf3 and Julie Di Paolo5, 1Immunology and Inflammation, Gilead Sciences, Foster City, CA, 2Gilead Sciences, Seattle, WA, 3Gilead Sciences, Foster City, CA, 4Biology Core Support, Gilead Sciences, Foster City, CA, 5Immunology and Inflammation Biology, Gilead Sciences, Inc., Foster City, CA

    Background/Purpose: SLE is a heterogeneous autoimmune disease characterized by immune system hyper-activation leading to the production of autoantibodies and immune attack on multiple organs including…
  • Abstract Number: 2121 • 2018 ACR/ARHP Annual Meeting

    Serum High Type I Interferon Is Associated with Active Proliferative Lupus Nephritis in Lupus Patients Accompanied with High Interferon Signature Gene Expression and Plasmacytoid Dendritic Cell Infiltration in Lupus Nephritis Kidney

    Taro Iwamoto1, Jessica M. Dorschner2, Mark A. Jensen1, Shanmugapriya Selvaraj3, Danielle Vsetecka2, Shreyasee Amin2, Ashima Makol2, Floranne C. Ernste2, Thomas Osborn2, Kevin Moder2, Vaidehi R. Chowdhary2, Valeria Mezzano4, Peter M. Izmirly5, H. Michael Belmont5, Robert M. Clancy1, Jill P. Buyon1, Ming Wu3, Cynthia A. Loomis3 and Timothy B. Niewold1, 1Colton Center for Autoimmunity, New York University, New York, NY, 2Mayo Clinic College of Medicine, Rochester, MN, 3Department of Pathology, New York University, New York, NY, 4Division of Cardiology, New York University, New York, NY, 5Division of Rheumatology, New York University, New York, NY

    Background/Purpose: Despite recent advancements in immunosuppressive therapies, lupus nephritis (LN) remains one of the most severe organ manifestations in systemic lupus erythematosus (SLE). High type…
  • Abstract Number: 2592 • 2017 ACR/ARHP Annual Meeting

    Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Intravenous Anifrolumab in Healthy Volunteers

    Raj Tummala1, Tomas Rouse2, Anna Berglind2 and Linda Santiago3, 1AstraZeneca, Gaithersburg, MD, 2AstraZeneca, Gothenberg, Sweden, 3MedImmune, LLC, Mountain View, CA

    Background/Purpose: Anifrolumab is a fully human anti–interferon-ɑ receptor 1 monoclonal antibody in Phase III development as an intravenous (IV) therapeutic for systemic lupus erythematosus (SLE).…
  • Abstract Number: 2601 • 2017 ACR/ARHP Annual Meeting

    Novel Anti-Malarial Drug Derivative Inhibited Type I Interferon Production and Autoimmune Inflammation in SLE Patient PBMC and in Trex1-/- Mouse Spleen and Heart

    Jie An1, Weinan Lai2,3, Joshua Woodward4, Xizhang Sun1, Lena Tanaka1, Tomikazu Sasaki5 and Keith B. Elkon6, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Department of Medicine/Division of Rheumatology, University of Washington, Seattle, WA, 3Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 4Department of Microbiology, University of Washington, Seattle, WA, 5Department of Chemistry, University of Washington, Seattle, WA, 6Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA

    Background/Purpose: Type I interferon (IFN-I) is strongly implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE) as well as rare monogenic ‘interferonopathies’ such as Aicardi-Goutieres…
  • Abstract Number: 2816 • 2017 ACR/ARHP Annual Meeting

    Prediction of Connective Tissue Disease in an at-Risk Cohort Using a Novel Interferon Stimulated Gene Expression Score

    Md Yuzaiful Md Yusof1,2, Yasser M El-Sherbiny1,3, Antonios Psarras1, Elizabeth M.A. Hensor1,4, Adewonuola Alase1, Alaa Mohamed1, Miriam Wittmann1,4, Paul Emery1,4 and Edward M Vital1,4, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Clinical Pathology dept., School of Medicine, Mansoura University, Mansoura, Egypt, 4NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Prediction of connective tissue disease in an at-risk cohort using a novel interferon stimulated gene expression scoreBackground/Purpose: A period of ANA positivity and other immune…
  • Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting

    A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression

    Ilya Korsunski1, Noémie Jourde-Chiche2, Peter Gregersen3, Damien Chaussabel4, Laurent Chiche5 and Naomi I. Maria6, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, 3Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, 4Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 5Internal medicine, Hopital europeen, Marseille, France, 6Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…
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