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Abstracts tagged "interferons"

  • Abstract Number: 844 • 2012 ACR/ARHP Annual Meeting

    Toll-Like Receptor 9-Independent and Immune Complex-Independent Interferon-α Production by Neutrophils Upon Netosis in Response to Circulating Chromatin

    Dennis Lindau1, Julie Mussard2, Armin Rabsteyn1, Matthieu Ribon2, Ina Kötter3, Annette Igney3, Gosse Adema4, Marie-Christophe Boissier5, Hans-Georg Rammensee1 and Patrice Decker6, 1Department of Immunology, University of Tübingen, Institute for Cell Biology, Tübingen, Germany, 2INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, 3Department of Internal Medicine II, Rheumatology Division, Tübingen, Germany, 4Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, 5Avicenne Hospital, Rheumatology Department, Bobigny, France, 6EA4222, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France

    Background/Purpose: Chromatin (which is composed of DNA and histones) represents a major autoantigen in systemic lupus erythematosus (SLE). Interferon-α (IFN-α) plays an important role in…
  • Abstract Number: 740 • 2012 ACR/ARHP Annual Meeting

    Select Soluble Inflammatory Mediators Are Detected Prior to and Increase At Systemic Lupus Erythematosus Classification

    Melissa E. Munroe1, Jourdan R. Anderson2, Julie M. Robertson3, Timothy B. Niewold4, George C. Tsokos5, Michael P. Keith6, John B. Harley7 and Judith A. James8, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 5Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, 6Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, 7Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 8Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation; Oklahoma University Health Sciences Center, Oklahoma City, OK

    Background/Purpose: The processes that lead to clinical illness in systemic lupus erythematosus (SLE) years before diagnosis are not well characterized.  Several cytokines have been associated…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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