ACR Meeting Abstracts
Abstract Number: 2281 • ACR/ARHP Annual Meeting 2012
Jie An1, Tracy A. Briggs2, Nalini Agrawal3, Alice Wiedeman4, Laurence Chaperot5, Joel Plumas5, Yanick J. Crow2 and Keith B. Elkon6, 1Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, 2Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 3Rheumatology, University of Washington, Seattle, WA, 4Department of Immunology, University of Washington, Seattle, WA, 5Inserm U823/Ujf/EFS, Immunobiology & Immunotherapy of Cancers, La Tronche, France, 6Rheumatology Box 356428, University of Washington, Seattle, WA
Background/Purpose: The enzyme tartrate-resistant acid phosphatase (TRAP) is highly expressed in osteoclasts. One of the main substrates for TRAP in bone matrix is osteopontin (OPN). …