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Abstracts tagged "interferons and monocytes"

  • Abstract Number: 1026 • ACR/ARHP Annual Meeting 2018

    Autoinflammatory Diseases, Particularly SAVI and Candle, Are Driven By Chronically Active Type I Interferons

    Bernadette Marrero1, Katherine R. Calvo2, Yin Liu3, Angelique Biancotto4, Yan Huang1 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 2Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, 3Scientific Review Branch, NIAMS/NIH, Bethesda, MD, 4Center for Human Immunology Autoimmunity and Inflammation (CHI), NIAID, NIH, Bethesda, MD

    Background/Purpose: STING Associated Vasculopathy with onset in Infancy (SAVI)is caused by gain-of-function mutations in TMEM173/STING and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature…
  • Abstract Number: 528 • ACR/ARHP Annual Meeting 2012

    Mxa As a Biomarker for Systemic Interferon Type I Activation in Primary Sjögren′s Syndrome

    Naomi I. Maria1, Zana Brkic1, Matti Waris2, Cornelia G. van Helden-Meeuwsen1, Kim Heezen1, Joop P. van de Merwe1, Paul L. van Daele3, Virgil A. Dalm3, Hemmo A. Drexhage3 and Marjan A. Versnel3, 1Immunology, Erasmus Medical Center, Rotterdam, Netherlands, 2Department of Virology, University of Turku, Turku, Finland, 3Erasmus Medical Center, Immunology, Rotterdam, Netherlands

    Background/Purpose: To establish an easy and practical assay for detection of systemic Interferon (IFN) type I activation in primary Sjögren's syndrome (pSS). The monocyte IFN…

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