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Abstracts tagged "interferons and juvenile dermatomyositis"

  • Abstract Number: 2920 • 2018 ACR/ARHP Annual Meeting

    Correlations of Type I Interferon Score and Interferon Induced Chemokines CXCL10 and CXCL9 with Cutaneous and Muscular Disease Activity in Juvenile Dermatomyositis

    Gian Marco Moneta1, Ivan Caiello1, Lucilla Rava'2, Silvia Rosina3, Luisa Bracci Laudiero1,4, Angelo Ravelli3,5, Fabrizio De Benedetti6 and Rebecca Nicolai7, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 2Epidemiology Unit, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 3University of Genova, Genova, Italy, 4Institute of Translational Pharmacology, CNR, Roma, Italy, 5Rheumatology, Giannina Gaslini Institute, Genova, Italy, 6IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 7Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

    Background/Purpose: Interferons (IFNs) seem to play an important role in the pathogenesis of juvenile dermatomyositis (JDM). We previously reported that expression of both type I…
  • Abstract Number: 2339 • 2017 ACR/ARHP Annual Meeting

    Expression of Type I and Type II Interferons Is Increased in Muscle Biopsies of Juvenile Dermatomyositis Patients and Related to Clinical and Histological Features

    Rebecca Nicolai1, Gian Marco Moneta2, Silvia Rosina3, Chiara Fiorillo3, Denise Pires Marafon1, Margherita Verardo4, Luisa Bracci Laudiero5,6, Carlo Minetti3,7, Angelo Ravelli3,8 and Fabrizio De Benedetti1, 1Division of Rheumatology, IRCCS Bambino Gesù Children's Hospital, Rome, Rome, Italy, 2Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Roma, Italy, 3University of Genova, Genova, Italy, 4Unit of Neuromuscular and Neurodegenerative Disorders, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Roma, Italy, 5Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Roma, Italy, 6Institute of Translational Pharmacology, CNR, Rome, Italy, Rome, Italy, 7Pediatric Neurology and Muscular Disorders, Giannina Gaslini Institute, Genova, Italy, 8Rheumatology, Giannina Gaslini Institute, Genova, Italy

    Background/Purpose: There is growing evidence for an involvement of interferons (IFNs) in the chronic inflammation that characterizes juvenile dermatomyositis (JDM). The aim of this study…
  • Abstract Number: 2340 • 2017 ACR/ARHP Annual Meeting

    Correlation of Type I Interferon Score and CXCL10 (C-X-C Motif Chemokine Ligand 10) with Cutaneous and Muscular Disease Activity in Juvenile Dermatomyositis Patients

    Rebecca Nicolai1, Gian Marco Moneta2, Ivan Caiello3, Denise Pires Marafon1, Silvia Rosina4, Luisa Bracci Laudiero5,6, Angelo Ravelli4,7 and Fabrizio De Benedetti1, 1Division of Rheumatology, IRCCS Bambino Gesù Children's Hospital, Rome, Rome, Italy, 2Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Roma, Italy, 3Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 4University of Genova, Genova, Italy, 5Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Roma, Italy, 6Institute of Translational Pharmacology, CNR, Rome, Italy, Rome, Italy, 7Rheumatology, Giannina Gaslini Institute, Genova, Italy

    Background/Purpose: Interferons (IFNs) seem to be important contributors in the pathogenesis of juvenile dermatomyositis (JDM). Our group previously reported that expression of both type I…
  • Abstract Number: 2103 • 2016 ACR/ARHP Annual Meeting

    Peripheral Blood B Cells Are Expanded and Their Cytokine Expression Is Dysregulated in Juvenile Dermatomyositis

    Meredyth Wilkinson1, Christopher Piper2, Georg Otto3, Claire Deakin4, Stefanie Dowle3, Stefania Simou5, Daniel Kelberman3, Yiannis Ioannou6, Claudia Mauri7, Elizabeth Jury8, David Isenberg9, Lucy R Wedderburn10 and Kiran Nistala11, 1Division of Medicine, University College London, London, United Kingdom, 2Rheumatology, University College London, London, United Kingdom, 3National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 4Infection, Inflammation and Rheumatology Section,, UCL Institute of Child Health, London, United Kingdom, 5Infection, Inflammation and Rheumatology, UCL Institute of Child Health, London, United Kingdom, 6Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 7Division of Medicine, Centre for Rheumatology Research, University College London, University College London, London, United Kingdom, 8Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, 9University College Hospital, London, London, United Kingdom, 10Infection, Inflammation and Rheumatology Section, UCL Institute of Child Health, London, United Kingdom, 11Centre for Rheumatology, University College London, London, United Kingdom

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and heliotrope rash. B cells are strongly…
  • Abstract Number: 2423 • 2016 ACR/ARHP Annual Meeting

    Differential Interferon Score Expression in the Peripheral Blood in Mendelian Inflammatory Interferonopathies Versus Juvenile Dermatomyositis (JDM) Subtyped By Myositis Autoantibodies and Disease Activity

    Hanna Kim1, Terrance P. O'Hanlon2, Adriana Almeida de Jesus3, Yan Huang3, Ira N. Targoff4,5, Frederick W. Miller2, Raphaela Goldbach-Mansky6 and Lisa G. Rider2, 1NIAMS/NIH, Bethesda, MD, 2Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 3National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5University of Oklahoma, Oklahoma City, OK, 6Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD

    Background/Purpose: JDM is a complex autoimmune disease with an interferon (IFN) signature, with a reported correlation with disease activity.  Clinical features vary among myositis-specific autoantibody…
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