ACR Meeting Abstracts

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Abstracts tagged "interferon"

  • Abstract Number: 1706 • ACR Convergence 2024

    Multi-omic Study in Patients with SITRAME Syndrome

    Yixiang Yves-Jean Zhu1, Angèle Soria2, Thomas Moreau3, Guilaine Boursier4, Vincent Bondet5, Françoise Donnadieu6, Clara Cretet7, Aness Haddouche7, Carine Schmidt3, Diego Bletry3, Emmanuelle Amsler2, Annick Barbaud2, Farah Rahal5, Yannick Chantran8, Margaux Cescato3, François Maillet9, Anne-Sophie Korganow10, Benjamin Chaigne11, Yannick Dieudonné10, Guillaume Lefevre12, Makoto Miyara7, Vivien Beziat13, Caroline Deswarte13, Michael White6, Sophie Georgin-lavialle1, Darragh duffy5 and Mathieu Paul Rodero3, 1Sorbonne Université, Department of internal medicine, Tenon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 2Sorbonne Université, Department of dermatology and allergology, Tenon hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 3Université Paris CIté, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Faculté des Saint-Pères, Paris, France, 4University of Montpellier, Montpellier, 5Translational Immunology Unit, Institut Pasteur, Université Paris-Cité, Paris, France, Paris, France, 6Pasteur Institut, Laboratoire d'épidémiologie et analyse des maladies infectieuses, Paris, France, 7Sobonne University, Centre d'Immunologie et des Maladies Infectieuses, Paris, France, 8Departmen of Biological Immunology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 9AP HP, Paris, France, 10University of Strasbourg, Department of Clinical Immunology and Internal Medicine, Nouvel Hôpital Civil, Strasbourg, France, 11Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, Ile-de-France, France, 12CHU Lille, Institut d’Immunologie, Lille, France., Lille, France, 13IMAGINE Institut, Human Genetics of Infectious Diseases Laboratory, Paris, France

    Background/Purpose: The SITRAME syndrome (Systemic Inflammatory Trunk Recurrent Acute Macular Eruption) is a newly described inflammatory entity affecting adult patients with no family history (Soria…
  • Abstract Number: 2199 • ACR Convergence 2024

    Mycobacterial Infection and Renal and Bladder Malignancy in 2 IFNopathy Patients on High Doses of JAK Inhibitors

    Sara Alehashemi1, Kader Cetin Gedik2, Cassandra Calabrese3, Sherry Nguyen4, Alexi Baumgardner4, Katsiaryna Uss4, Kip Friend4, Ariane Soldatos5, Adriana Almeida de Jesus6 and Raphaela Goldbach-Mansky7, 1NIH/NIAID/TADS, Potomac, MD, 2Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Pittsburgh, PA, 3Cleveland Clinic Foundation, Cleveland Heights, OH, 4Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Bethesda, MD, 5NINDS/NIH, Bethesda, MD, 6NIAID, NIH, Silver Spring, MD, 7Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Potomac, MD

    Background/Purpose: Autoinflammatory Type I Interferonopathies (IFNopathies) include STINGopathies (e.g., SAVI and COPA syndrome), proteasomopathies (e.g., CANDLE/Proteasome associated autoinflammatory syndrome (PRAAS), and oligonucleotidopathies (e.g., AGS: Aicardi-Goutières…
  • Abstract Number: 0901 • ACR Convergence 2024

    Intergenic Alu Elements Are Uniquely Expressed in Dermatomyositis and Correlate with Interferon Stimulated Genes

    Rayan Najjar1, Andrew Mammen2 and Tomas Mustelin1, 1University of Washington, Seattle, WA, 2NIH, Bethesda, MD

    Background/Purpose: As genes constitute < 2% of our genomes, there is a need to explore potential roles of other genomic elements in autoimmune disease. We…
  • Abstract Number: 1732 • ACR Convergence 2024

    In Vitro Screening of siRNAs Designed to Knockdown Interferon Beta as a Novel Therapeutic Approach for Treatment of Adult and Juvenile Dermatomyositis

    Joanna Parkes, Andrés Correa-Sánchez, Mark Cunningham and Peter Oliver, MRC Nucleic Acid Therapy Accelerator, Didcot, United Kingdom

    Background/Purpose: The main treatments for adult and juvenile dermatomyositis (DM/JDM) are immunosuppressant drugs and corticosteroids, which have significant side effects and are not effective in…
  • Abstract Number: 2288 • ACR Convergence 2024

    Interferon Gamma Signaling Is Associated with Development of Extraglandular Manifestations in Sjögren’s Disease

    Hiroyuki Nakamura1, Koki Nakamura1, Hidenori Amaike1, Ken Nagahata1, Masatoshi Kanda2 and Hiroki Takahashi1, 1Sapporo Medical University, Sapporo, Japan, 2Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan, Sapporo, Japan

    Background/Purpose: Sjögren’s disease (SjD) is an autoimmune disease that primarily affects salivary and lacrimal glands. Some patients with SjD develop various extraglandular manifestations (EGM), such…
  • Abstract Number: 0919 • ACR Convergence 2024

    The Effects of CB2R Activation on Inflammatory Pathways in Dermatomyositis

    Rohan Dhiman1, Ahmed Eldaboush2, Navin Vijayarangan3, Darae Kang3, Caroline Stone2, Nilesh Kodali3, DeAnna Diaz3 and Victoria Werth4, 1University of Pennsylvania, Newport Coast, CA, 2University of Pennsylvania, Philadelphia, PA, 3PennMedicine, Philadelphia, 4Hospital of the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Previous in vitro investigations done by our group into the utility of CB2R activation to treat dermatomyositis (DM) used stimulants that activated pathways not…
  • Abstract Number: 1762 • ACR Convergence 2024

    Multi-omic Analysis Defines Heterogeneous and Cell Specific Type I Interferon Signalling in Juvenile-onset SLE Patients Associated with Biomarkers of Cardiovascular Risk

    Junjie Peng, Thomas McDonnell, Elizabeth Jury, Coziana Ciurtin and George Robinson, University College London, London, United Kingdom

    Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disease characterised by chronic inflammation, multi-organ damage, and/or death. Despite their young age, jSLE patients have…
  • Abstract Number: 2376 • ACR Convergence 2024

    Systemic Lupus Erythematosus Patients Exhibit Dynamic Changes in Disease-Associated Transcripts Following Total Knee or Total Hip Arthroplasty

    David Fernandez1, Stephen Batter1, Deanna Jannat-Khah1, Mikhail Olferiev1, Insa Mannstadt2, Mark Figgie1, Peter Sculco1, Jason Blevins1, Caroline Siegel1, Dina Greenman1, Kyriakos Kirou1 and Susan Goodman3, 1Hospital for Special Surgery, New York, NY, 2Columbia University VP&S, New York, NY, 3Hospital for Special Surgery, New York 10025, NY

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) undergoing total hip arthroplasty and total knee arthroplasty (THA and TKA) experience higher complication rates than osteoarthritis (OA)…
  • Abstract Number: 0951 • ACR Convergence 2024

    A Feedback Loop Involving mtDNA, Platelets and Neutrophil Extracellular Traps Amplifies Inflammation in Systemic Sclerosis

    Stavros Giaglis1, Diego Kyburz2 and Ulrich Walker3, 1Experimental Rheumatology Laboratory, University of Basel, Basel, Switzerland, 2University Hospital Basel, Basel, Switzerland, 3Basel University Hospital, Basel, Switzerland

    Background/Purpose: Mitochondria are essential eucaryotic cell organelles with several bacterial features, such as a double-stranded circular genome with hypomethylated CpG areas (1). A fundamental role of…
  • Abstract Number: 1766 • ACR Convergence 2024

    STAT2-Associated Type I Interferonopathy: A Masquerade of Infectious Susceptibility

    Conor Gruber1, Angelica Lee2, Sofija Buta2, Marta Martin Fernandez2, Veronique Houdouin3, Jean-Laurent Casanova4, Alice Hadchouel5, Jacinta Bustamante5 and Dusan Bogunovic2, 1Mount Sinai Hospital, New York, NY, 2Columbia University, New York, NY, 3Robert Debré Hospital, Paris, France, 4Rockefeller University, New York, NY, 5Hôpital Necker-Enfants Malades, Paris, France

    Background/Purpose: Type I IFN (IFN-I) signaling is a potent inflammatory pathway fundamental to antiviral immunity. In humans, loss of IFN-I activity underlies severe viral disease,…
  • Abstract Number: 2385 • ACR Convergence 2024

    Increased Type I Interferon Inducible Genes Expression in the Peripheral Blood of Patients Presenting Cutaneous Lupus Erythematosus Manifestations

    Anastasia- Bilio Chronopoulou1, Maria Gerochristou2, Sylvia Raftopoulou3, Alexander Stratigos4 and Clio Mavragani5, 1National and Kapodistrian University of Athens, Athens, Greece, 2Andreas Syggros Hospital, National and Kapodistrian University of Athens, Athens, Greece, 3Molecular and Applied Physiology Unit, Department of Physiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece, 41st Department of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece, 5Department of Physiology and Pathophysiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece

    Background/Purpose: Cutaneous Lupus Erythematosus (CLE) is a chronic autoimmune skin disease characterized by a spectrum of cutaneous manifestations resulting from immune dysregulation and inflammation. While…
  • Abstract Number: 0954 • ACR Convergence 2024

    Increased Proliferating Natural Killer Cells Exhibit an Aberrant Pro-Inflammatory Gene Signature in Systemic Sclerosis Patients

    Pietro Bearzi1, Elena Pachera2, Sophie Wagner3, Astrid Hofman4, Lumeng Li4, Laura Much4, Mike Becker5, Kristina Bürki4, Luca Navarini6, Anna-Maria Hoffmann-Vold7, Roberto Giacomelli8 and Oliver Distler9, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3University of Zurich, Schlieren, Switzerland, 4Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 6Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy, 7Oslo University Hospital, Oslo, Norway, 8Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome "Campus Bio-Medico", Roma, Italy, 9Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland

    Background/Purpose: Recent transcriptomic data suggest a prominent involvement of innate immune cells in the pathogenesis of SSc. In this regard, contrasting data on NK cells…
  • Abstract Number: 1768 • ACR Convergence 2024

    A Potential Role of Longstanding IL-18 Stimulation in the Susceptibility for Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis

    Greta Rogani1, Remco Erkens1, Marein Putmans1, Rianne Scholman1, Jorg van Loosdregt2 and Sebastiaan Vastert1, 1University Medical Center Utrecht, Utrecht, Netherlands, 2University Medical Center Utrecht, La Jolla, CA

    Background/Purpose: Macrophage Activation Syndrome (MAS) is a pathologic condition of immune hyperactivation, which occurs in 10-30% of cases of Still’s Disease (SD), the spectrum of…
  • Abstract Number: 2397 • ACR Convergence 2024

    Increase of IL10 and IFNa2 Are Associated to Clinical Activity in Systemic Lupus Erythematous Patients

    Elena Grau García1, Marta De la Rubia Navarro2, Samuel Leal Rodriguez1, José Ivorra-Cortés3, Carmen Riesco Barcena4, Anderson Huaylla Quispe4, Laura Mas Sánchez5, Pablo Muñoz Martínez6, Daniel Ramos Castro4, Alba Torrat noves7, Iago Alcantara Alvarez2, Belén Villanueva Mañés2, Miguel Simeo Vinaixa2, Andrés Pérez Hurtado4 and Jose A Román-Ivorra8, 1HUP La Fe, Valencia, Spain, 2Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, 3Hospital Universitario La Fe, PALMA DE MALLORCA, Spain, 4Rheumatology Department. HUP La Fe, Valencia, Spain, 5Resident at Hospital Universitari i Politecnic La Fe, Valéncia, Spain, 6Hospital Universitario y Politècnico La Fe, Sagunto, Spain, 7Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Comunidad Valenciana, Spain, 8Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain

    Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease characterized by deregulation of cytokine production. Interferon (IFN) is a proinflamatory cytokine considered as a key…
  • Abstract Number: 0970 • ACR Convergence 2024

    Deubiquitylase (DUB) BRCC36 Isopeptidase Complex (BRISC) Inhibitors Prevent IFNAR1 Deubiquitination to Restore Natural Type I IFN Response in Autoimmunity

    Rebecca Ross1, Poli Adi Narayanna Reddy2, Joseph Salvino2, Elton Zeqiraj3 and Francesco Del Galdo3, 1Medicine and Health, University of Leeds, Leeds, United Kingdom, 2The Wistar Institute, Philadelphia, PA, 3University of Leeds, Leeds, United Kingdom

    Background/Purpose: Increased Type I IFN activation plays a key role in Scleroderma (SSc), Systemic Lupus Erythematosus and Inflammatory Myositis. Deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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