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Abstracts tagged "interferon and B cell tolerance"

  • Abstract Number: 884 • 2019 ACR/ARP Annual Meeting

    Interferon-Alpha Disrupts Multiple B Cell Tolerance Mechanisms in 3H9 Mice

    Dario Ferri 1, Yuriy Baglaenko 2, Kieran Manion 3, Carolina Munoz-Grajales 4 and Joan Wither5, 1University Health Network, Toronto, ON, Canada, 2Brigham Woman's Hospital, Boston, 3Krembil Research Institute, Toronto, ON, Canada, 4University Health Network, Toronto, Canada, 5University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Interferon-alpha (IFNα) is elevated in Systemic Lupus Erythematosus (SLE) and is thought to play a central role in its pathogenesis. Amongst IFNα’s many effects…
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