Abstracts tagged "insulin resistance and rheumatoid arthritis (RA)"

Abstract Number: 532 • 2018 ACR/ARHP Annual Meeting
Relationship between Insulin Sensitivity and Beta Cell Secretion in Non-Diabetic Rheumatoid Arthritis Subjects
Esmeralda Delgado-Frías¹, Beatriz-Segura Tejera², Raquel Lopez-Mejías³, De Vera-González AM⁴, Alejandro Jiménez-Sosa⁵, Jose M Olmos⁶, José Luis Hernández⁷, Javier Llorca^8,9, Miguel Angel González-Gay^3,10,11,12 and Iván Ferraz-Amaro², ¹Division of Rheumatology.Hospital Universitario de Canarias, La Laguna, Spain, ²Division of Rheumatology.Hospital Universitario de Canarias, Tenerife, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁴Division of Central Laboratory. Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ⁵Research Unit. Hospital Universitario de Canarias, Tenerife, Spain, ⁶Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria., Santander, Spain, ⁷Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ⁸Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain, ⁹CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ¹⁰School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ¹¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ¹²Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: In non-diabetic healthy individuals insulin secretion and insulin sensitivity are linked by a negative feedback loop characterized by a hyperbolic function. We aimed to…
Abstract Number: 534 • 2018 ACR/ARHP Annual Meeting
Increased Insulin Resistance and Impaired Beta-Cell Function in Patients with Rheumatoid Arthritis: The Role of Glucocorticoid Therapy?
Gorica Ristic¹, Vesna Subota², Dejana Stanisavljevic³, Branislava Glisic¹, Milan Petronijevic¹ and Dusan Stefanovic¹, ¹Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia, ²Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia, ³Institute of Medical Statistics, Belgrade University School of Medicine, Belgrade, Serbia
Background/Purpose: Increased insulin resistance and impaired β-cell function have been demonstrated in rheumatoid arthritis (RA). The aim of the study was to analyze the association…
Abstract Number: 1476 • 2018 ACR/ARHP Annual Meeting
Implication of CXCL5 (Epithelial neutrophil-activating peptide 78) in the Development of Insulin Resistance in Patients with Rheumatoid Arthritis
Sonia Peña¹, Beatriz-Segura Tejera², Raquel Lopez-Mejías³, De Vera-González AM⁴, Alejandra Gonzalez-Delgado⁵, Miguel Angel González-Gay⁶ and Iván Ferraz-Amaro⁷, ¹Rheumatology, Servicio de Reumatología, Hospital Universitario de Canarias,Spain, La Laguna, Spain, ²Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁴Division of Central Laboratory. Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ⁵Division of Central Laboratory. Hospital Universitario de Canarias., Tenerife, Spain, ⁶Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ⁷Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain
Background/Purpose: The chemokine molecule CXCL5 (C-X-C motif chemokine ligand 5, also known as epithelial neutrophil activating peptide 78 -ENA78-) constitutes a link between obesity, inflammation…
Abstract Number: 1379 • 2017 ACR/ARHP Annual Meeting
Epithelial Neutrophil-Activating Peptide 78/C-X-C Motif Chemokine 5 in the Insulin Resistance of Patients with Rheumatoid Arthritis
Hiurma Sanchez-Perez¹, Beatriz-Segura Tejera², De Vera-González AM³, Alejandra González Delgado⁴, Jose M Olmos⁵, José Luis Hernandez⁶, Begoña Ubilla⁷, Raquel Lopez-Mejías⁸, Miguel Angel González-Gay⁹ and Ivan Ferraz-Amaro¹⁰, ¹Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ²Rheumatology section, Hospital Germans Trias i Pujol, Badalona, Spain, ³Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ⁴Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, ⁵Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, ⁶Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁸Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Johannesburg, South Africa, ¹⁰Rheumatology, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
Background/Purpose: It is known that the chemokine molecule CXCL5 (C-X-C motif chemokine 5 or epithelial neutrophil activating peptide 78 -ENA78-) is a link between obesity,…
Abstract Number: 1400 • 2017 ACR/ARHP Annual Meeting
Beneficial Effect of Anti-IL-6 Blockade on Insulin Resistance and Insulin Sensitivity in Patients with Rheumatoid Arthritis
Raquel López-Mejías¹, Fernanda Genre¹, Sara Remuzgo-Martínez¹, Begoña Ubilla¹, Veronica Mijares¹, Jaime Calvo-Alen², Javier Llorca³, Santos Castañeda⁴ and Miguel Angel González-Gay⁵, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Rheumatology Department, Hospital Universitario Araba, Vitoria-Gasteiz, Spain, ³Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁴Hospital Universitario La Princesa. IIS-IP. Madrid. Spain, Madrid, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL. School of Medicine, University of Cantabria., Santander, Spain
Background/Purpose: Systemic inflammation, insulin resistance, and endothelial dysfunction were implicated in the development of cardiovascular disease in rheumatoid arthritis (RA) [1-3]. Since insulin resistance can…
Abstract Number: 2403 • 2017 ACR/ARHP Annual Meeting
Amylin in the Insulin Resistance of Patients with Rheumatoid Arthritis
Ivan Ferraz-Amaro¹, Beatriz-Segura Tejera², De Vera-González AM³, Alejandra González Delgado⁴, José Luis Hernandez⁵, Jose M Olmos⁶, Begoña Ubilla⁷, Raquel Lopez-Mejias⁸ and Miguel Angel González-Gay⁹, ¹Rheumatology, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ²Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ³Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ⁴Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, ⁵Division of Internal Medicine., Hospital Universitario Marqués de Valdecilla, IDIVAL,, Santander, Spain, ⁶Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁸Department of Rheumatology, Hospital Marquez de Valdecilla, Santander, Spain, ⁹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Amylin is a 37-amino acid peptide that is stored in pancreatic beta cells and is co-secreted with insulin. Amylin and insulin levels rise and…
Abstract Number: 1528 • 2016 ACR/ARHP Annual Meeting
Incretin Axis in Non Diabetic Rheumatoid Arthritis Patients
Beatriz Tejera¹, De Vera-González AM², Alejandra González Delgado³, Raquel López-Mejías⁴, Begoña Ubilla⁴, Fernanda Genre⁴, Jose M Olmos⁵, José L Hernández⁶, Miguel Angel Gonzalez-Gay⁴ and Ivan Ferraz-Amaro⁷, ¹Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ²Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ³Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁵Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, ⁶Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL. Universidad de Cantabria. RETICEF, Santander, Spain, ⁷Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain
Background/Purpose: Cross-sectional study that encompassed 361 non-diabetes individuals; 151 patients with RA and 210 age- and sex-matched controls. IR by homeostatic model assessment (HOMA2), insulin,…
Abstract Number: 1992 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is an Independent Risk Factor for Increased Insulin Resistance and Impaired Beta-Cell Function: Impact of Disease Activity
Gorica Ristic¹, Vesna Subota², Dejana Stanisavljevic³, Branislava Glisic¹, Milan Petronijevic¹ and Dusan Stefanovic¹, ¹Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia, ²Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia, ³Institute of Medical Statistics, Belgrade University School of Medicine, Belgrade, Serbia
Background/Purpose: Increased insulin resistance and impaired β-cell function have been demonstrated in pts with rheumatoid arthritis (RA). The aim of our study was to investigate…
Abstract Number: 1625 • 2015 ACR/ARHP Annual Meeting
Role of Macrophages in the Cardiovascular Disease Associated to Rheumatoid Arthritis: Effects of ANTI-CCPS in the Phenotypic Switching and the Insulin Signalling
Patricia Ruiz-Limon, Yolanda Jiménez Gómez, Carlos Perez-Sanchez, MariCarmen Abalos-Aguilera, M.Ángeles Aguirre Zamorano, Jerusalem Calvo-Gutierrez, Rafaela Ortega, Eduardo Collantes-Estévez, Alejandro Escudero-Contreras, Chary Lopez-Pedrera and Nuria Barbarroja, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain
Background/Purpose: Macrophages play a key role in the pathogenesis of the rheumatoid arthritis (RA). Under certain stimulus conditions these cells are able to switch their…
Abstract Number: 418 • 2013 ACR/ARHP Annual Meeting
Assessment Of Treatment Effect Over Insulin Resistance and Adipokines In Patients With Early Rheumatoid Arthritis: A 6 Months Longitudinal Observational Study
Sara Manrique-Arija¹, José Rioja², Pedro Valdivielso², María América López-Lasanta³, Pilar Espiño⁴, Inmaculada Ureña⁵, Francisco G. Jiménez-Núñez⁵, Carmen M. Romero-Barco⁵ and Antonio Fernández-Nebro¹, ¹Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain, ²Department of Medicine. University of Malaga, Malaga, Spain, ³Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁴Hospital Carlos Haya. University of Malaga, Malaga, Spain, ⁵Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain
Background/Purpose: To analyze treatment effects over insulin resistance (IR), adipokines, inflammatory cytokines and clinical and laboratory characteristics in patients with early rheumatoid arthritis (RA). Methods:…
Abstract Number: 391 • 2013 ACR/ARHP Annual Meeting
Insulin Resistance As A Risk Factor For Subclinical Atherosclerosis In Rheumatoid Arthritis
Adel M. Elsayed¹, Samah A. El Bakry¹, S. A. M. Hassan¹, Rehab A. Rahman², Rania A. Abo-Shady³ and Nouran Abaza⁴, ¹Rheumatology Division of Internal medicine department, Ain Shams University, Cairo, Egypt, ²Radiology department, Ain Shams University, Cairo, Egypt, ³clinical pathology, Ain Shams University, Cairo, Egypt, ⁴Physical medicine, Rheumatology and Rehabilitation, Lecturer of Physical medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Background/Purpose: Insulin resistance (IR) is a state in which a high insulin concentration is associated with an inadequate response to glucose with normal or high…
Abstract Number: 1237 • 2012 ACR/ARHP Annual Meeting
Baseline Evaluation of Insulin Resistance in Patients with early Non-Treated Rheumatoid Arthritis
Sara Manrique-Arija¹, María América López-Lasanta², Pilar Espiño- Lorenzo², Pedro Valdivielso³, José Rioja³, Inmaculada Ureña¹, Francisco Gabriel Jimenez- Núñez¹, Carmen M. Romero-Barco¹, Veronica Rodríguez-García¹, Laura Nieves², Mari Carmen Ordoñez-Cañizares², Laura Cano², Maria Victoria Irigoyen² and Antonio Fernández-Nebro⁴, ¹Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain, ²Hospital Carlos Haya. University of Malaga, Malaga, Spain, ³Department of Medicine. University of Malaga, Malaga, Spain, ⁴Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain
Background/Purpose: High levels of inflammatory cytokines are associated with insulin resistance syndrome in long-standing AR. The aim was to analyze insulin resistance (IR), adipokines, inflammatory…
Abstract Number: 832 • 2012 ACR/ARHP Annual Meeting
Peroxisome Proliferator-Activated Receptor Gamma Agonist Treatment for Rheumatoid Arthritis: A Proof-of-Concept Randomized Controlled Trial
Michelle J. Ormseth¹, Annette M. Oeser², Andrew Cunningham², Aihua Bian², Ayumi Shintani², S. Bobo Tanner³ and C. Michael Stein⁴, ¹Rheumatology, Vanderbilt Medical Center, Nashville, TN, ²Vanderbilt Medical Center, Nashville, TN, ³Div of Rheumatology & Allergy, Vanderbilt Medical Center, Nashville, TN, ⁴School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: Rheumatoid arthritis (RA), a chronic inflammatory disease, is associated with insulin resistance. Experimental evidence indicates that the relationship between insulin resistance and inflammation is…

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