Abstracts tagged "Insulin-like growth factor"

Abstract Number: 933 • 2018 ACR/ARHP Annual Meeting
Inflammation in the Hippocampus Affects Insulin-like Growth Factor-1 Receptor Signaling and Contributes to Neurological Sequelae in Rheumatoid Arthritis
Karin Andersson¹, Caroline Wasén¹, Lina Juzokaite¹, Malin C Erlandsson^1,2, Anna Stokowska³, Lovisa Leifsdottir⁴, Marcela Pekna³, Milos Pekny³, Kjell Olmarker⁵, Rolf Heckemann^6,7,8, Marie Kalm⁹ and Maria I Bokarewa², ¹Department of rheumatology and inflammation research, University of Gothenburg, Gothenburg, Sweden, ²Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden, ³Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden, ⁴Rheumatology Clinics, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁵Department of Medical Chemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden, ⁶Med Tech West at Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, ⁷Department of Medical Radiation Science, University of Gothenburg, Gothenburg, Sweden, ⁸Faculty of Medicine, Imperial College London, London, United Kingdom, ⁹Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: The central nervous system is not the primary target in rheumatoid arthritis (RA). However, neuropsychiatric symptoms including pain, depression and anxiety are common and…
Abstract Number: 763 • 2017 ACR/ARHP Annual Meeting
Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis
Sara Garrett¹, Justin Thomas², Eileen Hsu³ and Carol A. Feghali-Bostwick⁴, ¹Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Eisenhower Medical Center, Rancho Mirage, CA, ³Kaiser Permanente Medical Group, Mclean, VT, ⁴Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Previous work has shown that insulin-like growth factor (IGF)-II is increased in fibrosing lung diseases, including idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis (SSc)-associated…
Abstract Number: 1100 • 2012 ACR/ARHP Annual Meeting
A Functional Growth Hormone Receptor Polymorphism, Exon 3 Deleted Ghr, Is Associated with Radiographic Knee Osteoarthritis in Females with Familial Osteoarthritis At Multiple Sites: The Garp Study
Kim M.J.A. Claessen¹, Margreet Kloppenburg², H.M. Kroon³, Jessica Bijsterbosch⁴, Alberto M. Pereira¹, Hans A. Romijn¹, Tahar Straaten van der⁵, Marian Beekman⁶, P.E. Slagboom⁶, Nienke R. Biermasz¹ and Ingrid Meulenbelt⁷, ¹Endocrinology, Leiden University Medical Center, Leiden, Netherlands, ²Department Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, ⁶Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁷The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Rotterdam, Netherlands
Background/Purpose: Genetic influences contribute considerably to the development of osteoarthritis (OA), and are most likely of a polygenic nature. Until now, genetic studies have identified…