ACR Meeting Abstracts

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Abstracts tagged "Insulin-like growth factor"

  • Abstract Number: 933 • 2018 ACR/ARHP Annual Meeting

    Inflammation in the Hippocampus Affects Insulin-like Growth Factor-1 Receptor Signaling and Contributes to Neurological Sequelae in Rheumatoid Arthritis

    Karin Andersson1, Caroline Wasén1, Lina Juzokaite1, Malin C Erlandsson1,2, Anna Stokowska3, Lovisa Leifsdottir4, Marcela Pekna3, Milos Pekny3, Kjell Olmarker5, Rolf Heckemann6,7,8, Marie Kalm9 and Maria I Bokarewa2, 1Department of rheumatology and inflammation research, University of Gothenburg, Gothenburg, Sweden, 2Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden, 3Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden, 4Rheumatology Clinics, Sahlgrenska University Hospital, Gothenburg, Sweden, 5Department of Medical Chemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden, 6Med Tech West at Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, 7Department of Medical Radiation Science, University of Gothenburg, Gothenburg, Sweden, 8Faculty of Medicine, Imperial College London, London, United Kingdom, 9Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: The central nervous system is not the primary target in rheumatoid arthritis (RA). However, neuropsychiatric symptoms including pain, depression and anxiety are common and…
  • Abstract Number: 763 • 2017 ACR/ARHP Annual Meeting

    Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis

    Sara Garrett1, Justin Thomas2, Eileen Hsu3 and Carol A. Feghali-Bostwick4, 1Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 2Eisenhower Medical Center, Rancho Mirage, CA, 3Kaiser Permanente Medical Group, Mclean, VT, 4Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: Previous work has shown that insulin-like growth factor (IGF)-II is increased in fibrosing lung diseases, including idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis (SSc)-associated…
  • Abstract Number: 1100 • 2012 ACR/ARHP Annual Meeting

    A Functional Growth Hormone Receptor Polymorphism, Exon 3 Deleted Ghr, Is Associated with Radiographic Knee Osteoarthritis in Females with Familial Osteoarthritis At Multiple Sites: The Garp Study

    Kim M.J.A. Claessen1, Margreet Kloppenburg2, H.M. Kroon3, Jessica Bijsterbosch4, Alberto M. Pereira1, Hans A. Romijn1, Tahar Straaten van der5, Marian Beekman6, P.E. Slagboom6, Nienke R. Biermasz1 and Ingrid Meulenbelt7, 1Endocrinology, Leiden University Medical Center, Leiden, Netherlands, 2Department Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands, Leiden, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, 6Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, 7The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Rotterdam, Netherlands

    Background/Purpose: Genetic influences contribute considerably to the development of osteoarthritis (OA), and are most likely of a polygenic nature. Until now, genetic studies have identified…
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