Abstracts tagged "innate immunity and spondylarthritis"

Abstract Number: 1582 • 2017 ACR/ARHP Annual Meeting
RORγt Inhibition Selectively Targets Pathogenic Subsets of Human iNKT and γδ-T Cells Enriched in Spondyloarthritis While Preserving Tissue Protective IL-22 Responses
Koen Venken^1,2, Mark Labadia³, Kathleen Hoyt³, Anita Wayne³, Robert Hughes³, Michael Turner³, Dustin Smith⁴, Christian Harcken⁴, Tine Decruy^5,6, Joseph Wahle⁷, Chao-Ting Wang³, Peggy Jacques⁸, Sofie Van Gassen⁹, Gaëlle Varkas¹⁰, Heleen Cypers¹⁰, Filip van Den Bosch¹¹, Yvan Saeys⁹, Gerald Nabozny¹² and Dirk Elewaut^13,14, ¹Department of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation,, Ghent, Belgium, ²VIB Inflammation Research Center, Ghent University, Ghent, Belgium, ³Research and Development Boehringer-Ingelheim, Ridgefield, CT, ⁴Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium, Ghent, Belgium, ⁶VIB Inflammation Research Center, Ghent, Belgium, ⁷Department of Immunology and respiratory discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁸Ghent University Hospital, Ghent, Belgium, ⁹Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium, ¹⁰Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ¹¹Rheumatology, Ghent University Hospital, Gent, Belgium, ¹²[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ¹³VIB Inflammation Research Center, University of Ghent, Ghent, Belgium, ¹⁴Department of Rheumatology, Laboratory for molecular immunology and inflammation, Ghent, Belgium
Background/Purpose: Dysregulated IL-23/IL-17 responses have been linked to a myriad of inflammatory diseases including psoriasis, psoriatic arthritis and other forms of spondyloarthritides (SpA). IL-23/IL-17 inflammation…
Abstract Number: 199 • 2015 ACR/ARHP Annual Meeting
Human Type 1 and Ncr-Negative Type 3 Innate Lymphoid Cells Accumulate in the Inflamed Synovium in Spondyloarthritis
Nataliya Yeremenko^1,2,3, Silvia Menegatti⁴, Troy Noordenbos^1,2,3, Leonieke J.J. van Mens^1,2, Iris C. Blijdorp^1,2,3, Kristine Germar^1,2,3, Jochem Bernink⁵, Lars Rogge⁴, Hergen Spits⁵ and Dominique Baeten^1,2,3, ¹Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, ²Department of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Laboratory of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Immunoregulation Unit, Institut Pasteur, Paris, France, ⁵Department of Cell Biology and Histology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Spondyloarthritis (SpA) is a major form of chronic inflammatory arthritis characterized by inflammation of axial and peripheral joints and by pathologic new bone formation…
Abstract Number: 201 • 2015 ACR/ARHP Annual Meeting
Innate Lymphoid Cells Are Present at Normal Human Enthesis Providing a Potential Mechanism for Spondyloarthropathy Pathogenesis
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Peter Millner², Robert Dunsmuir², Yasser El-Sherbiny¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom
Background/Purpose: The pathogenesis of murine spondyloarthropathy (SpA) has been intimately linked to the presence of IL-23 responsive, innate like lymphocytes at peripheral and spinal enthesis.…

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