Abstracts tagged "innate immunity and rheumatoid arthritis (RA)"

Abstract Number: 2427 • 2017 ACR/ARHP Annual Meeting
Exosomes Derived from T Lymphocytes Enhance Expression of CXCL10 Induced By IFN-γin Rheumatoid Arthritis Synovial Fibroblasts Via Pattern Recognition Receptor, RIG-I
Kunihiko Umekita, Shunichi Miyauchi, Koshou Iwao, Mao Rikitake, Yuuki Rikitake, Chihiro Kawada, Ayako Aizawa, Yumi Kariya, Motohiro Matsuda, Takeshi Kawaguchi, Hajime Nomura, Ichiro Takajo and Akihiko Okayama, Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan
Background/Purpose: Exosomes have been recognized to have a function in cell-to-cell communication by transporting various factors including proteins and nucleic acids. These factors impact cell…
Abstract Number: 32 • 2017 ACR/ARHP Annual Meeting
Longitudinal Associations between Rheumatoid Factor and Ex Vivo Cytokine Production Reveal Novel Mechanistic Insights into Rheumatoid Arthritis
John M. Davis III¹, Cynthia S. Crowson², Keith L. Knutson³, Sara J. Achenbach⁴, Terry M. Therneau⁵, Eric L. Matteson⁶, Sherine E. Gabriel⁷ and Peter J. Wettstein⁸, ¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, ³Immunology, Mayo Clinic, Jacksonville, FL, ⁴Mayo Clinic, Rochester, MN, ⁵Biostatistics, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁷Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ⁸Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Positive rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) identify a major rheumatoid arthritis (RA) subgroup, characterized by greater propensity to erosive joint damage…
Abstract Number: 286 • 2017 ACR/ARHP Annual Meeting
Serum Amyloid a Aggravates Rheumatoid Arthritis By Activating NFAT5-Mediated Migration of Macrophages
Yu-Mi Kim Sr.¹, Donghyun Kim Sr.¹, Seung-Ah Yoo Sr.², Jung Hee Koh Sr.², Jin-Sun Kong Sr.² and Wan-Uk Kim Sr.³, ¹Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ³The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: Serum amyloid A (SAA) is an acute phase protein and its serum levels may increase up to 1000-fold over normal levels during inflammation, triggering…
Abstract Number: 2258 • 2016 ACR/ARHP Annual Meeting
Role of NLRP12 on Disease Severity in Autoimmune Arthritis
Ryan Lupo and Peng Liu, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are cytoplasmic sensors that response to danger signals released by invading pathogen or self-damaged tissues. NLRP12 is a member…
Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting
Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice
Rebecca Baum¹, Kerstin Nundel¹, Sudesh Pawaria^1,2, Shruti Sharma¹, Patricia Busto¹, Tara Robidoux¹, Katherine A. Fitzgerald¹, Ellen M. Gravallese³ and Ann Marshak-Rothstein¹, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ³Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…

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