Abstracts tagged "innate immunity and mouse model"

Abstract Number: 2829 • 2015 ACR/ARHP Annual Meeting
Enhanced Expression of the Transcription Factor T-Bet Alters Pro-Inflammatory Cytokine Profile in Ankylosing Spondylitis
Max C. Lau¹, Patricia Keith¹, Mary-Ellen Costello¹, Linda A. Bradbury¹, Kelly A. Hollis¹, Gethin P. Thomas², Matthew A. Brown^1,3 and Tony J. Kenna¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Research Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16x10-10). T-bet is…
Abstract Number: 2358 • 2014 ACR/ARHP Annual Meeting
The Role of Dendritic Cells during Inflammatory Arthritis
Antonia Puchner¹, Victoria Saferding², Eliana Goncalves-Alves³, Josef Smolen⁴, Kurt Redlich⁵ and Stephan Blüml¹, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁵Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are…
Abstract Number: 2220 • 2013 ACR/ARHP Annual Meeting
The Role Of CD11c+ Dendritic Cells In Inflammatory Arthritis
Antonia Puchner¹, Stephan Blüml¹, Victoria Saferding², Harald Leiss¹, Josef S. Smolen³ and Kurt Redlich⁴, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are…