Abstracts tagged "innate immunity and monocytes"

Abstract Number: 1823 • 2018 ACR/ARHP Annual Meeting
Loss of Synovial Tissue Resident Macrophages Permits Monocyte to Macrophage Differentiation and Inflammation in Hupo Mice
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We established a mouse model (HUPO) by deletion of Flip in CD11c+ cells that spontaneously develops erosive inflammatory arthritis resembling rheumatoid arthritis (RA). Since…
Abstract Number: 1815 • 2014 ACR/ARHP Annual Meeting
STAT3-Mediated Regulation of Mitochondrial Membrane Potential Is Critical for NLRP3 Inflammasome Activation
Jehad H. Edwan¹, Raphaela Goldbach-Mansky² and Robert A. Colbert³, ¹NIAMS NIH, Bethesda, MD, ²NIAMS, NIH Building 10 Room 6D47B, Bethesda, MD, ³NIAMS/NIH, Bethesda, MD
Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…