ACR Meeting Abstracts

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Abstracts tagged "innate immunity and monocytes"

  • Abstract Number: 1823 • 2018 ACR/ARHP Annual Meeting

    Loss of Synovial Tissue Resident Macrophages Permits Monocyte to Macrophage Differentiation and Inflammation in Hupo Mice

    Qi Quan Huang1, Renee E. Doyle2, Alexander Misharin3, Shang-Yang Chen4, Deborah R. Winter5 and Richard M. Pope2, 1Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, 5Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: We established a mouse model (HUPO) by deletion of Flip in CD11c+ cells that spontaneously develops erosive inflammatory arthritis resembling rheumatoid arthritis (RA). Since…
  • Abstract Number: 1815 • 2014 ACR/ARHP Annual Meeting

    STAT3-Mediated Regulation of Mitochondrial Membrane Potential Is Critical for NLRP3 Inflammasome Activation

    Jehad H. Edwan1, Raphaela Goldbach-Mansky2 and Robert A. Colbert3, 1NIAMS NIH, Bethesda, MD, 2NIAMS, NIH Building 10 Room 6D47B, Bethesda, MD, 3NIAMS/NIH, Bethesda, MD

    Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…
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