ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "innate immunity and interferons"

  • Abstract Number: 1022 • 2018 ACR/ARHP Annual Meeting

    TNF-α Regulates Plasmacytoid Dendritic Cells By Suppressing IFN-α Production and Enhancing Th1 and Th17 Cell Differentiation

    Antonios Psarras1,2,3, Agne Antanaviciute4, Ian Carr4, Miriam Wittmann1,2, Paul Emery1,5, George C Tsokos6 and Edward M Vital1,2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 4Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, 5Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. pDCs can produce massive amounts of type I IFNs in response…
  • Abstract Number: 184 • 2016 ACR/ARHP Annual Meeting

    Upregulation and Activation of the IFI16-Sting-IRF3-IFN Pathway in Sjogren’s Salivary Glands

    Brendan Antiochos1, Livia Casciola-Rosen2 and Antony Rosen3, 1Rheumatology, Johns Hopkins University School of Medicine, Maltimore, MD, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Type I IFN expression is known to be upregulated in the salivary glands of patients with SjogrenÕs syndrome, but the upstream stimuli responsible for…
  • Abstract Number: 1157 • 2013 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular Damage In Mice

    Jason S. Knight1, Wei Luo2, Alexander A. O'Dell1, Wenpu Zhao3, Venkataraman Subramanian4, Chiao Guo2, Robert C. Grenn3, Paul Ryan Thompson4, Daniel T. Eitzman2 and Mariana J. Kaplan5, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan Cardiology, Ann Arbor, MI, 3University of Michigan Rheumatology, Ann Arbor, MI, 4The Scripps Research Institute, Jupiter, FL, 5Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD

    Background/Purpose:   Neutrophil extracellular trap (NET) formation promotes vascular damage, while stimulating interferon alpha (IFN-α) production in diseased arteries.  Patients with rheumatoid arthritis and systemic…
  • Abstract Number: 764 • 2013 ACR/ARHP Annual Meeting

    Inflammatory Disease Due To Dysregulated Nuclear Factor-κB Activation and Impaired Type I Interferon Response Resulting From a De Novo Human NEMO Hypomorphic Mutation

    Alex Wessel1, Amy Hsu2, Jevgenia Zilberman-Rudenko1, Raphaela Goldbach-Mansky3, Richard M. Siegel1 and Eric Hanson1, 1Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Laboratory of Clinical Infectious Diseases, NIAID, Bethesda, MD, 3Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose: The NF-kB family of transcription factors regulate innate and adaptive immunity, in addition to driving pro-inflammatory-disease states.  The type I interferon response acts in…
  • Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting

    Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice

    Jennifer Scott1, Osama S. Naga2, Melissa A. Cunningham3, Jena Wirth3, Jackie G. Eudaly2 and Gary S. Gilkeson4, 1Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 2Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, 3Med/Rheumatology, MUSC, Charleston, SC, 4Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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