Abstracts tagged "injury and polymorphism"

Abstract Number: 1867 • 2015 ACR/ARHP Annual Meeting
Functional Androgen Receptor Variants Associated with Greater Damage in Systemic Lupus Erythematosus
Yun Deng¹, Jennifer M. Grossman^1,2, Qiong Fu¹, William J. Martin¹, Judith A. James³, Joan T. Merrill⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁵, Susan A. Boackle⁶, Chaim Putterman⁷, Jane E. Salmon⁸, Vasileios C. Kyttaris⁹, George C. Tsokos⁹, Matthew Quirk¹⁰, Seema Kamble¹, Melissa Barcelona¹, Erika Magdangal¹⁰, Lori Sahakian¹¹, Seung Yoon Lee¹, Tracy Y. Lin¹, Weiling Chen¹, Jennifer M.P. Woo¹², Ornella J. Rullo¹², Deborah K. McCurdy¹², Bevra H. Hahn^13,14, Maureen A. McMahon¹¹, Sang-Cheol Bae¹⁵ and Betty P. Tsao¹, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ²Rheumatology, UCLA, Los Angeles, CA, ³Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, Albert Einstein College of Medicine, New York, NY, ⁸Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁹Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ¹⁰Division of Rheumatology, Department of Medicine,, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ¹¹Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ¹²Pediatric Rheumatology, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, ¹³Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ¹⁴Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA, ¹⁵Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose :Organ damage predicts physical disability and mortality of SLE. Given that men with SLE tend to develop accelerated damage, we selected an X-linked androgen…

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