Abstract Number: 122 • 2019 ACR/ARP Annual Meeting
Inhibition of Necroptosis Suppresses Muscle Cell Death and Inflammatory Infiltrate, and Improves Muscle Strength in Experimental Polymyositis
Background/Purpose: In polymyositis (PM), CD8+ cytotoxic T lymphocytes (CTLs) are assumed to induce muscle cell death. We presumed that the injured muscle cells release pro-inflammatory…Abstract Number: 402 • 2019 ACR/ARP Annual Meeting
Chronic Disease Course and IVIg-dependance in Long-term Follow-up of Anti-HMGCR Immune-mediated Necrotizing Myopathy
Background/Purpose: Anti-HMGCR antibodies have been associated with a severe form of immune-mediated necrotizing myopathy (IMNM) with a poor muscle strength recovery and early muscle damage.…Abstract Number: 410 • 2019 ACR/ARP Annual Meeting
Prevalence of Malignancy in Myositis Patients with Anti-aminoacyl-tRNA Synthetase Antibodies: A Single Center Retrospective Study and Literature Review
Background/Purpose: Anti-aminoacyl-tRNA synthetase antibodies (anti-ARS antibodies) are related to Idiopathic Inflammatory Myopathy (IIM) and Anti-Synthetase Syndrome (ASS). While anti-TIF1-γ antibody and anti-NXP-2 antibody are highly…Abstract Number: 1280 • 2019 ACR/ARP Annual Meeting
JAK Inhibitors: A Promising Molecular-targeted Therapy in Dermatomyositis
Background/Purpose: We previously observed in vitro that IFN-I reproduces dermatomyositis (DM) pathological findings, that pathogenic effects may be prevented in vitro by JAK inhibitor (JAKinh) therapy and an improvement…Abstract Number: 1287 • 2019 ACR/ARP Annual Meeting
Anti-mitochondrial Autoantibodies in Idiopathic Inflammatory Myopathies
Background/Purpose: Autoantibodies found in adult and juvenile myositis patients are often associated with specific clinical features. Prior reports have suggested that the myositis-associated autoantibody, anti-mitochondrial…Abstract Number: 1288 • 2019 ACR/ARP Annual Meeting
Line Blot Immunoassay in Inflammatory Myopathies: Diagnostic Accuracy and Factors Predicting Positive Results in Routine Clinical Practice
Background/Purpose: To evaluate the real-world accuracy of a line blot immunoassay (LIA) for myositis-specific (MSA) and myositis-associated (MSA) autoantibody testing in patients at a tertiary…Abstract Number: 1867 • 2019 ACR/ARP Annual Meeting
Body Composition in Myositis Patients Is Negatively Changed Compared to Healthy Controls and the Changes Are Associated with Disease Activity and Duration, Skeletal Muscle Involvement and Physical Activity and Nutritional Status
Background/Purpose: Skeletal muscle, pulmonary and articular involvement in idiopathic inflammatory myopathies (IIM) limit the mobility/self-sufficiency of patients, and can have a negative impact on body…Abstract Number: 1870 • 2019 ACR/ARP Annual Meeting
NMR-Based Serum, Urine and Muscle Metabolomics in Inflammatory Myositis for Diagnosis and Activity Assessment: Serum Metabolomics Can Differentiate Active from Inactive Myositis
Background/Purpose: Differentiating smouldering disease activity from weakness due to fatty replacement of atrophied muscle can often be a challenge in Idiopathic Inflammatory Myositis (IIM). There…Abstract Number: 1871 • 2019 ACR/ARP Annual Meeting
Myositis-Specific Antibodies and Muscle Histopathology in Juvenile Dermatomyositis: New Insights into the Mechanism of Injury
Background/Purpose: Myositis-specific antibodies (MSAs) are identified in over half of children with JDM and are associated with distinct clinical phenotypes. MSA subtype, in combination with…Abstract Number: 2428 • 2019 ACR/ARP Annual Meeting
Serum Myositis Specific/associate Autoantibodies Help Identify Early Connective Tissue Diseases Relevant Interstitial Lung Diseases: A Medical Center Experience
Background/Purpose: Interstitial lung diseases (ILD), a heterogeneous group of pulmonary disorders, originated from idiopathic causes or secondary to certain etiologies, such as infectious diseases, drugs,…Abstract Number: 377 • 2018 ACR/ARHP Annual Meeting
Preliminary Validation of Rectus Femoris Muscle Ultrasound in Idiopathic Inflammatory Myopathy Patients
Background/Purpose: Muscle ultrasound (MUS) offers a cost effective, accessible option for detection of muscle inflammation and atrophy in patients with Idiopathic Inflammatory Myopathies (IIM). The…Abstract Number: 387 • 2018 ACR/ARHP Annual Meeting
Increased Risk of Malignancy in Elderly Patients with Inflammatory Myositis
Background/Purpose: The association between inflammatory myositis and malignancy is well established, however, the risk of malignancy in aged patients is known to be similar with…Abstract Number: 2165 • 2017 ACR/ARHP Annual Meeting
Easily Obtainable Myositis Autoantibody Panel Predictive Factors
Background/Purpose: Myositis autoantibodies have diagnostic, therapeutic and prognostic implications, but their utility in clinical practice is unclear. We aimed to describe our institutionÕs ordering practices…Abstract Number: 2169 • 2017 ACR/ARHP Annual Meeting
A Two-Center Experience with Rituximab in Patients with Primary Idiopathic Myositis and Overlap Myositis: A Retrospective Observational Study
Background/Purpose: Recent studies have suggested the possible benefit of the anti-CD20 agent Rituximab (RTX) in autoimmune myositis (AIM). As AIM is a rare and heterogeneous…Abstract Number: 2143 • 2017 ACR/ARHP Annual Meeting
Circulating Endothelial Cells and Endothelial Activation Markers As Disease Activity Measures in Idiopathic Inflammatory Myopathies
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases with chronic muscle inflammation and microvasculopathy of muscle and skin capillaries. Circulating endothelial cells (CECs),…
ACR Meeting Abstracts