Abstracts tagged "inflammatory cytokines and systemic sclerosis"

Abstract Number: 1907 • ACR/ARHP Annual Meeting 2015
Inhibition of Phosphodiesterase 4 (PDE4) Reduces Dermal Fibrosis By Interfering with the Release of Pro-Fibrotic Cytokines from M2-Macrophages
Christiane Maier, Christian Beyer, Jeorg HW Distler and Georg Schett, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: PDE4 catalyses the breakdown of the second messengers cAMP and cGMP to modulate intracellular effects. PDE4 is mainly expressed in inflammatory cells, and its…
Abstract Number: 1747 • ACR/ARHP Annual Meeting 2013
Plasma MCP-1 and IL-10 Levels Predict Long-Term Progression Of Interstitial Lung Disease In Patients With Early Systemic Sclerosis
Minghua Wu¹, Claudia Pedroza², Gloria Salazar¹, Xiaodong Zhou¹, John D. Reveille¹, Maureen D. Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: The currently available clinical markers are not reliable predictors of long-term progression of systemic sclerosis (SSc) related interstitial lung disease (ILD). SSc patients have…