Abstracts tagged "inflammatory cytokines and rheumatoid arthritis (RA)"

Abstract Number: 975 • 2017 ACR/ARHP Annual Meeting
IL-17A Induced Autophagy That the Proliferation of Rheumatoid Arthritis Fibroblast-like Synoviocytes through Down-Regulation of PI3K/AKT/mTOR Signaling Pathway
Sang-Hyon Kim¹, Jihye Bang², Ji-Min Kim¹, Chang-Nam Son¹, Jin-Nyeong Chae¹ and Hye-Jin Jeong³, ¹Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea, Daegu, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, Republic of (South), ³Department of Rheumatology, Keimyung University Dongsan Medical Center, Daegu, Korea, Republic of (South)
Background/Purpose: Autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Fibroblast-like synoviocytes (FLS) resistance to…
Abstract Number: 1511 • 2016 ACR/ARHP Annual Meeting
Impacts of Disease Activity and Serum Level of Neurotrophic Factors on Depression in Rheumatoid Arthritis
Young Sun Suh¹, Yun-Hong Cheon², Hyun-Ok Kim¹, Hye Song Lim³, Hae Sook Noh³, Sang-Hyon Kim⁴, Ji-Min Kim⁴, Chang-Nam Son⁴, Seung-Geun Lee⁵, Eun-Kyoung Park⁵ and Sang-Il Lee³, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ³Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁴Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, ⁵Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of
Background/Purpose: Rheumatoid arthritis (RA) and depression is closely associated with each other. The serum level of neurotrophic factors are related with the major depressive disorder…
Abstract Number: 1922 • 2016 ACR/ARHP Annual Meeting
TNF-α and IL-6 Induced Upregulation of CCR5 and CXCR3 Participate in Vδ2 Chemotaxis in RA
Wenxiu MO¹, Shanshan YIN¹, Chen ZHOU¹ and Xuan Zhang², ¹Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Vδ2T cells, a subpopulation of γδ T cells with inflammatory features, play a vital role in inflammation, tumor immunology, infectious disease and autoimmunity. However,…
Abstract Number: 2013 • 2015 ACR/ARHP Annual Meeting
TIARP Attenuates Autoantibody-Mediated Arthritis Via the Suppression of Neutrophil Infiltration into the Joint
Asuka Inoue¹, Isao Matsumoto¹, Yuki Tanaka², Naoto Umeda¹, Hoshimi Kawaguchi¹, Hiroshi Ebe¹, Yoshihiro Matsumoto³ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan, ³Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: TIARP (TNFα-induced adipose-related protein) is dominantly expressed in macrophages (Mφ), neutrophils (PMN) and fibroblast-like synoviocytes (FLS). Recently, we found that TIARP functions as a…
Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting
Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?
Kimberly P. Liang¹, Douglas P. Landsittel², Suresh R. Mulukutla³, Steven E. Reis⁴, Marc C. Levesque⁵, Donald M. Jones⁶, Rachel Gartland⁷, Ali Shoushtari⁸, Flordeliza S. Villanueva³, Hunter C. Champion⁸ and Larry W. Moreland⁵, ¹Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, ³Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…

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