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Abstracts tagged "inflammatory cytokines and autoantibodies"

  • Abstract Number: 2033 • ACR/ARP Annual Meeting 2019

    IRAK4 Inhibition Suppresses TLR7, TLR9, and SLE Serum-Induced IFNA Production in Primary Human Plasmacytoid Dendritic Cells

    Angie Hammond1, Sean Parghi 1, Nathan Wright 1, Ethan Grant 1, James Taylor 1 and Matthew Warr 1, 1Gilead Sciences, Inc., Foster City, CA

    Background/Purpose: A hallmark of lupus is the presence of antinuclear autoantibodies, including those against RNA-protein complexes and double-stranded DNA (dsDNA).1,2 FcγR-mediated internalization of these nucleic…

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