Abstracts tagged "inflammatory bowel disease (IBD) and inflammatory cytokines"

Abstract Number: 33 • 2019 ACR/ARP Annual Meeting
GS-4875, a First-in-Class TPL2 Inhibitor Suppresses MEK-ERK Inflammatory Signaling and Proinflammatory Cytokine Production in Primary Human Monocytes
Matthew Warr¹, Angie Hammond ¹, Grace Park ¹, Zhi-Hua Cui ¹, Nathan Wright ¹ and James Taylor ¹, ¹Gilead Sciences, Inc., Foster City, CA
Background/Purpose: Tumor progression locus 2 (TPL2, also known as MAP3K8) is a mitogen-activated protein kinase kinase kinase and the primary regulator of ERK-mediated gene transcription…

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Abstracts tagged "inflammatory bowel disease (IBD) and inflammatory cytokines"

GS-4875, a First-in-Class TPL2 Inhibitor Suppresses MEK-ERK Inflammatory Signaling and Proinflammatory Cytokine Production in Primary Human Monocytes