Abstracts tagged "inflammatory arthritis and metabolism"

Abstract Number: 2134 • 2015 ACR/ARHP Annual Meeting
Metabolic Reprogramming in the Inflamed Joint Inhibits Pro-Inflammatory Mechanisms
Monika Biniecka¹, Mary Canavan¹, Chin Teck Ng², Wei Gao¹, Thomas Smith³, Trudy McGarry⁴, Douglas J. Veale⁵ and Ursula Fearon⁴, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ²Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, ³Department of Endocrinology, St Vincent’s University Hospital, Dublin, Ireland, ⁴St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁵St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: To examine the relationship between synovial hypoxia, cellular bioenergetics and mitochondrial dysfunction with synovial inflammation. Methods: Primary RASFC were cultured with 3% hypoxia, DMOG…

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