Abstracts tagged "inflammation and vasculitis"

Abstract Number: 1768 • 2017 ACR/ARHP Annual Meeting
Cocaine and ANCA Associated Vasculitis-like Syndromes – a Case Series
Sujith Subesinghe¹, Sander van Leuven², Leena Yalakki³, Shirish Sangle (Joint First Author)³ and David P. D'Cruz³, ¹Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom, ²Rheumatology, Radboud University, Nijmegen, Netherlands, ³Louise Coote Lupus Unit, Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom
Background/Purpose: Cocaine is a potent illicit stimulant and may trigger a ÔpseudovasculitisÕ mimicking idiopathic ANCA vasculitis. We describe the clinical and serological manifestations of patients…
Abstract Number: 2345 • 2017 ACR/ARHP Annual Meeting
Characterization of Adenosine Deaminase 2 Variants Identified in an International Pediatric Vasculitis Cohort
Kristen Gibson^1,2, David Cabral^3,4, Britt Drogemoller⁵, Xiaohua Xhan⁵, Fudan Miao⁶, Kimberly Morishita⁷, Erin Gill⁸, Robert E. W. Hancock⁸, Colin Ross^5,9 and Kelly Brown^9,10, ¹Medical Genetics, The University of British Columbia, Vancouver, BC, Canada, ²BC Children's Hospital Research Insitute, Vancouver, BC, Canada, ³BC Children's Hospital, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada, ⁶The University of British Columbia, Vancouver, BC, Canada, ⁷BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ⁸Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada, ⁹BC Children's Hospital Research Institute, Vancouver, BC, Canada, ¹⁰Pediatrics, The University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is a recently recognized, autosomal recessive genetic disease. Patients present with various, early-onset systemic vascular and inflammatory manifestations,…
Abstract Number: 1925 • 2016 ACR/ARHP Annual Meeting
Interest of Procalcitonin for the Follow-up of ANCA-Associated Vasculitis: Data from a Cohort of 99 Patients
Anne Lemaire¹, Roderau Outh¹, Alexandre Mania¹, Geoffroy Marceau², Pauline Berland³, Marc Andre⁴ and Olivier Aumaître⁵, ¹Internal Medicine CHU G Montpied, Internal Medicine, CLERMONT-FERRAND, France, ²Biology, Medical Biochemistry, CLERMONT-FERRAND, France, ³Epidemiology, Epidemiology, CLERMONT-FERRAND, France, ⁴Internal Medicine CHU G Montpied, Internal Medicine, Clermont Ferrand, France, ⁵Division of internal Medicine, Centre Hospitalier Universitaire, Hôpital Gabriel Montpied, Clermont–Ferrand, Clermont–Ferrand, France
Background/Purpose: The prognosis of the ANCA associated vasculitis (AAV) has improved with the new immunosuppressive treatments but infectious complications remain frequent. Procalcitonin (PCT) is…
Abstract Number: 2151 • 2016 ACR/ARHP Annual Meeting
Fractalkine (CX3CL1) Is Expressed By Arterial Endothelium and Vascular Smooth Muscle Cells (VSMC) in GCA
Marc Corbera-Bellalta¹, Ester Planas-Rigol², Nekane Terrades-Garcia¹, Marco Antonio Alba¹, Georgina Espígol-Frigolé², Sergio Prieto-González², Jose Hernández-Rodríguez¹ and Maria C. Cid³, ¹Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Department of Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain
Background/Purpose: The development of giant-cell arteritis (GCA) lesions requires amplification cascades resulting in continuous recruitment of lymphocytes and monocytes. Interferon-gamma (IFNg)- induced or up-regulated chemokines…
Abstract Number: 892 • 2015 ACR/ARHP Annual Meeting
Autoimmune Associated Orbital Inflammatory Masses and Response to Immunosuppressive Therapy
Alina Casian¹, Shirish Sangle (joint first author)², Ritu Malaiya³, Pamela Lutalo⁴, Louise Nel⁵, Bina Menon⁶, Hema Varma⁷, Miles Stanford⁸ and David P. D'Cruz⁵, ¹Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, UK, London, United Kingdom, ²Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom, ³Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁴Rheumatology, St. George's Hospital, London, United Kingdom, ⁵Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom, ⁶Rheumatology, Guy's Hospital, London, United Kingdom, ⁷Radiology, Guy's and St. Thomas' Hospital, London, United Kingdom, ⁸Ophthalmology, Guy's and St. Thomas' Hospital, London, United Kingdom
Background/Purpose: To characterize a single centre retrospective case series of patients with orbital inflammatory masses associated with autoimmune diseases including granulomatosis with polyangiitis(GPA)(formerly Wegener’s granulomatosis),…
Abstract Number: 3032 • 2015 ACR/ARHP Annual Meeting
Role of Adenosine and Neutrophils in Inflammation Associated with Mutations in CECR1 Gene
Kyawt W. Shwin^1,2, Carmelo Carmona-Rivera³, Wanxia Tsai⁴, Chya-chia Richard Lee^5,6, Elaine Novakovich⁷, Deborah L. Stone⁸, Amanda K. Ombrello⁸, Raphaela Goldbach-Mansky⁹, Massimo Gadina¹⁰, Daniel Kastner¹¹, Ivona Aksentijevich^12,13, Mariana J. Kaplan⁷ and Peter C. Grayson^14,15, ¹NIAMS, National Institutes of Health, BETHESDA, MD, ²Translational Autoinflammatory Diseases Section, National Institutes of Health, Bethesda, MD, ³Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology, Office of Science and Technology, National Institutes of Health, Bethesda, MD, ⁵National Cancer Institute, National Institutes of Health, Bethesda, MD, ⁶Laboratory of Pathology, NCI, National Institutes of Health, BETHESDA, MD, ⁷Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, ⁸National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁹Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ¹⁰Translational Immunology, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, MD, ¹¹Inflammatory Disease Section, NHGRI, National Institutes of Health, Bethesda, MD, ¹²NIH/NHGRI, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, Bethesda, MD, ¹³Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ¹⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁵NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD
Background/Purpose: The phenotype of patients afflicted by deficiency of adenosine deaminase 2 (DADA2) due to mutations in CECR1encoding ADA2 protein shares many features with idiopathic…
Abstract Number: 2352 • 2012 ACR/ARHP Annual Meeting
Temporal Artery Biopsy Culture in Tridimensional Matrix. an in Vitro Model for Functional Studies in Giant-Cell Arteritis
Marc Corbera Bellalta¹, Ester Planas Rigol¹, Ester Lozano¹, Marco A. Alba², Itziar Tavera-Bahillo¹, Sergio Prieto-González¹, Georgina Espígol Frigolé¹, Montserrat Butjosa¹, José Hernández-Rodríguez¹, Ana García-Martínez³ and Maria C. Cid⁴, ¹Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clinic University Barcelona, Barcelona, Spain, ²Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Department of Emergency Medicine, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁴Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Background/Purpose: GCA is the most frequent systemic vasculitis in Europe and North America. In spite of the initial response to glucocorticoid treatment more than 60%…
Abstract Number: 859 • 2012 ACR/ARHP Annual Meeting
Endothelin-1 (ET-1) Induces Extracellular Matrix Protein Production by Human Temporal Artery Derived Myointimal Cells. A Mechanism Potentially Leading to Intimal Hyperplasia and Vascular Occlusion in Giant-Cell Arteritis
Ester Planas-Rigol¹, Marc Corbera-Bellalta², Marco A. Alba³, Itziar Tabera-Bahillo³, Sergio Prieto-Gonzalez³, Georgina espigol-Frigole³, Jose Hernandez-Rodriguez⁴, Ester Lozano⁵ and Maria C. Cid⁶, ¹Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Hospital Clinic University Barcelona, Hospital Clinic University Barcelona, Barcelona, Spain, ³Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clinic University Barcelona, Barcelona, Spain, ⁴Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁵Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clinic University Barcelona, ⁶Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Background/Purpose: Endothelin-1 (ET-1) is the main isoform of the Endothelin family. It is also the most powerful vasoconstrictor identified. ET-1 is constitutively produced in blood…

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