Abstracts tagged "inflammation and uric acid"

Abstract Number: 2250 • 2018 ACR/ARHP Annual Meeting
Mitigation of Inflammation Induced By Monosodium Urate Crystals in Mice By Treatment with Svp-Rapamycin
Pallavi Kolte, Robert LaMothe, Joseph Ferrari, Sheldon Leung, Wesley DeHaan Ph.D., Earl Sands and Takashi Kei Kishimoto, Selecta Biosciences, Watertown, MA
Background/Purpose: Initiation of urate-lowering therapies is typically associated with an increase in gout flares due to mobilization of pro-inflammatory urate crystals. SEL-212 is a novel…
Abstract Number: 2346 • 2015 ACR/ARHP Annual Meeting
Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1b Production through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells
Jung-Yoon Choe¹, Minyoung Her² and Seong-Kyu Kim³, ¹Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, South Korea, ²Busan Paik Hospital, Inje University, Busan, South Korea, ³Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea
Background/Purpose: This study investigated the effect of rebamipide on activation of NLRP3 inflammasome and reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1b (IL-1b)…
Abstract Number: 1223 • 2014 ACR/ARHP Annual Meeting
Enhancement of Proinflammatory Cytokine Production By Uric Acid in Human Cells Via Down Regulation of IL-1Ra
Tania Crisan¹, Maartje Cleophas², Heidi Lemmers³, Helga Toenhake-Dijkstra¹, Mihai Netea¹, Tim Jansen⁴ and Leo Joosten¹, ¹Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud Unversity Medical Center, Nijmegen, Netherlands, ³Internal Medicine, Radboud Univeristy Medical Center, Nijmegen, Netherlands, ⁴Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…
Abstract Number: 1724 • 2013 ACR/ARHP Annual Meeting
The Role Of Low-Grade Inflammation In The Association Between Uric Acid and Atherosclerosis: The Codam Study
José M.A. Wijnands¹, Annelies Boonen², Pieter C. Dagnelie³, Marleen M.J. van Greevenbroek⁴, Carla J.H, van der Kallen⁵, Isabel Ferreira⁴, Casper G. Schalkwijk⁴, Edith J.M. Feskens⁶, Sjef van der Linden², Coen D.A. Stehouwer⁷ and Ilja C.W. Arts³, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University, Maastricht, Netherlands, ²Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Epidemiology, Maastricht University, Maastricht, Netherlands, ⁴Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, ⁵Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, ⁶Division of Human Nutrition, Wageningen University, Wageningen, Netherlands, ⁷Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: Uric acid may be involved in the atherosclerotic process by increasing the level of low-grade inflammation. The aims of this study were: 1) to…

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