Abstracts tagged "inflammation and scleroderma"

Abstract Number: 784 • 2012 ACR/ARHP Annual Meeting
Neutralization of Plasminogen Activator Inhibitor-1 Resolves Skin Fibrosis and Vascular Injury in a Murine Model of Human Scleroderma
Raphael Lemaire¹, Tim Burwell¹, Tracy Delaney¹, Cindy Chen², Julie Bakken¹, Lily Cheng¹, Philip Brohawn¹, Isabelle de Mendez³, Dominic Corkill³, Anthony Coyle⁴, Ronald Herbst² and Jane Connor¹, ¹Research, MedImmune LLC, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, ³Research, Medimmune, LLC, Cambridge, England, ⁴Centers for Therapeutic Innovation, Pfizer, Inc., Cambridge (formerly at MedImmune LLC, Gaithersburg, MD, USA), MA
Background/Purpose: Scleroderma is a systemic autoimmune disease in which thrombosis and fibrosis contribute to skin pathology. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of…

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Abstracts tagged "inflammation and scleroderma"

Neutralization of Plasminogen Activator Inhibitor-1 Resolves Skin Fibrosis and Vascular Injury in a Murine Model of Human Scleroderma