Abstracts tagged "inflammation and rheumatoid arthritis (RA)"

Abstract Number: 2912 • 2017 ACR/ARHP Annual Meeting
The Neural Correlates of Inflammation in RA: A Multi-Modal MRI Study
Andrew Schrepf¹, Chelsea Cummiford¹, Eric Ichesco¹, Tony Larkin¹, Steven E. Harte¹, Richard E. Harris¹, Alison Murray², Gordon Waiter³, Daniel J. Clauw⁴ and Neil Basu⁵, ¹Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ²Aberdeen Brain Imaging Center, University of Aberdeen, Aberdeen, United Kingdom, ³Aberdeen Brain Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, ⁴Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁵Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
Background/Purpose: Inflammation is the hallmark of disease activity in rheumatoid arthritis (RA). RA is characterized by fatigue and cognitive/affective disturbances, and these symptoms often worsen…
Abstract Number: 528 • 2016 ACR/ARHP Annual Meeting
Assessment of Metacarpal Head Bone Microarchitecture According to Presence or Not of Inflammation in Rheumatoid Arthritis Patients with Low Disease Activity
Shuing Kong¹, Hervé Locrelle¹, Adamah Amouzougan¹, Delphine Denarie¹, Philippe Collet¹, Béatrice Pallot Prades¹, Thierry Thomas^1,2 and Hubert Marotte^1,2, ¹Rheumatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France, ²INSERM U1059/LBTO, Université de Lyon - Université Jean Monnet, Saint-Etienne, France
Background/Purpose: Bone alteration at the metacarpeal head during rheumatoid arthritis (RA) disease remained under investigated. High‐resolution peripheral quantitative computed tomography (HRpQCT) allows exploration of microarchitecture…
Abstract Number: 1438 • 2016 ACR/ARHP Annual Meeting
Tofacitinib Restores Reverse Cholesterol Transport Inhibition Induced By Inflammation. Understanding the Lipid Paradox
Sandra Pérez-Baos¹, Juan I. Barrasa², Paula Gratal¹, Ane Larrañaga-Vera¹, Iván Prieto-Potin¹, Gabriel Herrero-Beaumont¹ and Raquel Largo¹, ¹Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ²Joint and Bone Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain
Background/Purpose: Patients with active rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality, paradoxically in association with reduced circulating levels of total cholesterol…
Abstract Number: 1494 • 2016 ACR/ARHP Annual Meeting
Myocardial Structure, Function, and Fibrosis in Patients with Rheumatoid Arthritis and Matched Control Subjects
Michelle J. Ormseth¹, William Bradham², Comfort Elumogo³, Srikanth Palanisamy⁴, Chia Liu⁵, Mark Lawson², Jonathan Soslow², Nadine Kawel⁶, David A. Bluemke⁷ and C Michael Stein², ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN, ³National Institutes of Health, Bethesada, MD, ⁴Cornell University, Ithaca, NY, ⁵National Institutes of Health, Bethsada, MD, ⁶National Institutes of Health, Bethsada, TN, ⁷National Institutes of Health, Bethesda, MD
Background/Purpose: The prevalence of heart failure is increased 2-fold in RA; this is not explained by ischemic heart disease or other risk factors for heart…
Abstract Number: 2152 • 2016 ACR/ARHP Annual Meeting
S100A11 Protein Is Increased in Rheumatoid Arthritis and Is Associated with Disease Activity and Inflammation
Lucie Andres Cerezo¹, Barbora Šumová¹, Klára Prajzlerová¹, David Veigl², Karel Pavelka¹, Jiří Vencovský³ and Ladislav Senolt³, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²1st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Calgizzarin (S100A11) is a member of the S100 protein family that acts in different tumors via regulating number of biologic functions. Recent data suggest…
Abstract Number: 901 • 2015 ACR/ARHP Annual Meeting
Novel B Cell-Derived Peptide Regulation of Homeostatic T-Cell Trafficking Is Subverted in Rheumatoid Arthritis
Helen McGettrick¹, Myriam Chimen², Ashley Martin³, Francesca Barone⁴, Andrew Filer⁵, Karim Raza⁶, Christopher Buckley⁴, Parth Narendran⁷ and G. Ed Rainger², ¹Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ²Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom, ³School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁷Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: In rheumatoid arthritis (RA), inappropriate recruitment of T-cells into the joint contributes to disease pathogenesis and joint destruction. We examined the ability of adiponectin…
Abstract Number: 1320 • 2015 ACR/ARHP Annual Meeting
Assessment of 18F-Fluoro-Deoxyglucose Uptake in the Ascending Aorta of Rheumatoid Arthritis Patients
Ayse Bag Ozbek¹, Jon Giles¹, Richard Weinberg², Mona Kinkhabwala², Afshin Zartoshti¹, Sabahat Bokhari² and Joan Bathon¹, ¹Rheumatology, Columbia University Medical Center, NY, NY, ²Cardiology, Columbia University Medical Center, NY, NY
Background/Purpose: Increased cardiovascular (CV) disease risk in RA has been attributed to traditional CV risk factors and/or to enhanced inflammation. Increased subclinical vascular inflammation has…
Abstract Number: 1553 • 2015 ACR/ARHP Annual Meeting
Effect of Drug Therapy on Net Cholesterol Efflux Capacity of HDL-Enriched Serum in Rheumatoid Arthritis
Michelle J. Ormseth¹, S. Louis Bridges Jr.², Jeffrey R. Curtis³, Joseph F. Solus⁴, Patricia Yancey⁵, MacRae F. Linton⁶, Sean Davies⁶, L Jackson Roberts II⁷, Kasey C. Vickers⁶, Valentina Kon⁶, Sergio Fazio⁸, C Michael Stein⁶ and TETRAD Investigators, ¹Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, TN, ²Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Pharmacology, Vanderbilt University, Nashville, TN, ⁵Medicine, Vanderbilt University, Nashville, TN, ⁶Vanderbilt University, Nashville, TN, ⁷Pharmacology, Vanderbilt University, Nashville, TN, ⁸Oregon Health and Science University, Portland, OR
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary heart disease risk. Some RA therapies may modify this risk, but underlying mechanisms are unclear. The…
Abstract Number: 2561 • 2015 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor, Demonstrates Potent Efficacy in an Animal Model of Rheumatoid Arthritis
Fumihito Hosoi, Youhei Yoshiga, Satoru Iguchi, Ryuusuke Kaneko, Yoshinori Nakachi, Daichi Akasaka, Kazuhiko Yonekura, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., TSUKUBA, Japan
Background/Purpose: Bruton’s tyrosine kinase (BTK) is a member of the Tec family kinases, and is expressed in B cells, monocytes/macrophages, mast cells, basophils and osteoclast1,2.…
Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting
The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis
Lisa Deloch¹, Anja Derer¹, Axel J. Hueber², Barbara Happich³, Rainer Fietkau¹, Benjamin Frey¹ and Udo S. Gaipl¹, ¹Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…
Abstract Number: 1902 • 2014 ACR/ARHP Annual Meeting
Utility of Glyca, a Novel Inflammatory Marker, for Assessment of Rheumatoid Arthritis Disease Activity
Michelle Ormseth¹, Cecilia P. Chung², Joseph F. Solus³, Annette M. Oeser³, Margery A. Connelly⁴, Jim Otvos⁴ and C Michael Stein³, ¹Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Vanderbilt University, Nashville, TN, ⁴LipoScience, Inc., Raleigh, NC
Background/Purpose GlycA is a novel inflammatory biomarker measured from the nuclear magnetic resonance (NMR) spectra obtained for lipoprotein particle analysis. It represents a distinct peak…
Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting
ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts
Takeo Isozaki^1,2, Sho Ishii², Shinichiro Nishimi², Airi Maeoka², Mayu Saito², Nao Oguro², Shinya Seki², Yoko Miura², Yusuke Miwa², Koei Oh³, Yoichi Toyoshima³, Masanori Nakamura³, Katsunori Inagaki³ and Tsuyoshi Kasama², ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ³Department of Orthopedics, Showa University School of Med, Tokyo, Japan
Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…
Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Sanjay Garg¹, Dipak R. Patel² and Raymond Yung³, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Internal Med-Univ Michigan, University of Michigan, Ann Arbor, MI
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 354 • 2014 ACR/ARHP Annual Meeting
Increased Vascular Wall Inflammation in Patients with Active Rheumatoid Arthritis As Measured By an 18F-FDG-PET/CT Scan
Rabia Agca^1,2, Alper M. van Sijl^2,3, Yvo M. Smulders⁴, Alexandre E. Voskuyl⁵, Connie J. van der Laken⁶, Ronald Boellaard⁷, Karel-Jan D.F. Lensen⁸ and Michael T. Nurmohamed^1,2, ¹Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ²VU University Medical Center, Amsterdam, Netherlands, ³[email protected], Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁴Internal Medicine, VU University Medical Center, Amsterdam, Netherlands, ⁵Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁶Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁷Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, ⁸Department of Internal Medicine, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose : Patients with rheumatoid arthritis (RA) have an elevated risk of developing cardiovascular disease (CVD). Like active RA, atherosclerosis is an inflammatory process. There…

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