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Abstracts tagged "inflammation and regulatory cells"

  • Abstract Number: 5 • ACR/ARHP Annual Meeting 2018

    Short Chain Fatty Acid Acetate Induces Regulatory B Cells in Mice and Humans, Which Can Protect Against Arthritis

    Claire I. Daien1,2,3, Julie Mielle1,4, Rachel Audo1,2,5, Lake-Ee Quek1, James Krycer1, Gauthier Rathat6, Gabriela Pinget1, Sumaiya Hoque7, Charles Mackay8, Jian Tan9 and Laurence Macia1, 1Charles Perkins Centre, The University of Sydney, Sydney, Australia, 2IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 3Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, 4IGMM CNRS UMR5535, Montpellier, France, 5Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, 6Arnaud-de-Villeneuve Hospital, Montpellier, France, 7Charles Perkins Centre, The University of Sydney, Sydney, France, 8Monash University, Melbourne, Australia, 9Charles Perkins Centre, The University of Sydney, Montpellier, Australia

    Background/Purpose: Autoimmunity and more broadly non-communicable diseases develop with the imbalance between anti- and pro-inflammatory immune cell subsets, leading to an uncontrolled and damaging inflammation.…
  • Abstract Number: 2936 • ACR/ARHP Annual Meeting 2016

    All-Trans Retinoic Acid Stabilizes Natural T Regulatory Cells Isolated from Patients with Systemic Lupus Erythematosus Under Inflammatory Conditions

    Julie Wang1, Zixuan Qiao2, Feng Huang3, Ya Liu2, Nancy J. Olsen4 and Song Guo Zheng5, 1Medicine, Penn State Hershey Medical Center, Hershey, PA, 2Medicine, Xuzhou Medical University, Xuzhou, China, 3Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, 4Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, 5Medicine/Rheumatology, Penn State University Hershey Medical Center, Hershey, PA

    Background/Purpose: Recent studies have demonstrated that naturally occurring CD4+Foxp3+regulatory T cells (nTregs) are unstable and dysfunctional in the presence of pro-inflammatory cytokines. All-trans RA (atRA),…

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