Abstracts tagged "inflammation and regulatory cells"

Abstract Number: 5 • 2018 ACR/ARHP Annual Meeting
Short Chain Fatty Acid Acetate Induces Regulatory B Cells in Mice and Humans, Which Can Protect Against Arthritis
Claire I. Daien^1,2,3, Julie Mielle^1,4, Rachel Audo^1,2,5, Lake-Ee Quek¹, James Krycer¹, Gauthier Rathat⁶, Gabriela Pinget¹, Sumaiya Hoque⁷, Charles Mackay⁸, Jian Tan⁹ and Laurence Macia¹, ¹Charles Perkins Centre, The University of Sydney, Sydney, Australia, ²IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ³Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ⁴IGMM CNRS UMR5535, Montpellier, France, ⁵Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ⁶Arnaud-de-Villeneuve Hospital, Montpellier, France, ⁷Charles Perkins Centre, The University of Sydney, Sydney, France, ⁸Monash University, Melbourne, Australia, ⁹Charles Perkins Centre, The University of Sydney, Montpellier, Australia
Background/Purpose: Autoimmunity and more broadly non-communicable diseases develop with the imbalance between anti- and pro-inflammatory immune cell subsets, leading to an uncontrolled and damaging inflammation.…
Abstract Number: 2936 • 2016 ACR/ARHP Annual Meeting
All-Trans Retinoic Acid Stabilizes Natural T Regulatory Cells Isolated from Patients with Systemic Lupus Erythematosus Under Inflammatory Conditions
Julie Wang¹, Zixuan Qiao², Feng Huang³, Ya Liu², Nancy J. Olsen⁴ and Song Guo Zheng⁵, ¹Medicine, Penn State Hershey Medical Center, Hershey, PA, ²Medicine, Xuzhou Medical University, Xuzhou, China, ³Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ⁴Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ⁵Medicine/Rheumatology, Penn State University Hershey Medical Center, Hershey, PA
Background/Purpose: Recent studies have demonstrated that naturally occurring CD4+Foxp3+regulatory T cells (nTregs) are unstable and dysfunctional in the presence of pro-inflammatory cytokines. All-trans RA (atRA),…

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