Abstracts tagged "inflammation and monocytes"

Abstract Number: 1000 • 2018 ACR/ARHP Annual Meeting
Surface Adenosine Monophosphate Deaminase 2 As a Novel Regulator Modifying Ectonucleotidase-Driven Generation of Anti-Inflammatory Extracellular Adenosine
Lisa Ehlers^1,2, Aditi Kuppe^1,2, Alexandra Damerau^3,4, Yuling Chen^1,2, Cindy Strehl^3,5, Marieluise Kirchner⁶, Frank Buttgereit¹ and Timo Gaber^3,5, ¹Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ²German Rheumatism Research Centre Berlin, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ⁵Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany, ⁶BIH Core Facility Proteomics, Max Delbrück Centre for Molecular Medicine, Berlin, Germany
Background/Purpose: Extracellular ATP and adenosine are potent immunomodulatory molecules that accumulate in states of inflammation. ATP/ADP are released from damaged or stressed cells and sequentially…
Abstract Number: 2120 • 2018 ACR/ARHP Annual Meeting
CD47- Signal Regulatory Protein Alpha Interaction Potentiates Proinflammatory Response in Systemic Lupus Erythematosus
Jin Kyun Park¹, Ye Ji Lee², Ji Soo Park³, Eun Young Lee⁴, Eun Bong Lee⁴ and Yeong Wook Song⁵, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ²Department of Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Seoul National University College of Medicine, Seoul, Korea, Republic of (South)
CD47-Signal Regulatory Protein-Alpha Interaction Potentiates Proinflammatory Response in Systemic Lupus Erythematosus.Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease mediated by unbalanced activation of…
Abstract Number: 302 • 2017 ACR/ARHP Annual Meeting
From Monocytes to Macrophages: the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang¹, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a CD11c-Flip-KO mouse line (HUPO) that spontaneously develops erosive arthritis with incidence 70-80% at age ≥ 20 weeks. This study aimed…
Abstract Number: 1142 • 2013 ACR/ARHP Annual Meeting
Distinct Pathways Of Ly6C^hi Monocyte Development Identified By a Novel Dual-Reporter Murine Myeloid Progenitor Cell Line
Pui Lee¹, David Sykes², Sarah Ameri³, Demetrios Kalaitzidis², Peter A. Nigrovic⁴ and Astrid Cardona⁵, ¹Boston Children's Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Division of Immunology, Boston Children's Hospital, Boston, MA, ⁵University of Texas - San Antonio, San Antonio, MA
Background/Purpose: Monocytes are essential to innate immunity but also propagate the inflammatory response in autoimmune arthritis and crystal arthropathies. Development of inflammatory monocytes (Ly6Chi CCR2+)…
Abstract Number: 1803 • 2012 ACR/ARHP Annual Meeting
Chemokine-Like Receptor 1 (CMKLR1), a G Protein Coupled Receptor Expressed On Proinflammatory Monocytes in Arthritis, Is Negatively Regulated by GRK3
D. Stephen Serafin¹, Roman Timoshchenko¹, Marcus W. McGinnis² and Teresa K. Tarrant³, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina Sch of Med, Chapel Hill, NC, ³Medicine/Rheumatology, UNC School of Medicine, Chapel Hill, NC
Background/Purpose: Chemokine-like receptor 1 (CMKLR1) is a G protein coupled receptor (GPCR) expressed by inflammatory monocytes that are pathogenic in human diseases such as psoriasis…

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