Abstracts tagged "inflammasome activation"

Abstract Number: 2904 • 2013 ACR/ARHP Annual Meeting
Gadolinium-Based Compounds Induce NLRP3-Dependent IL-1β Production and Peritoneal Inflammation
Jonathan Kay^1,2, Lukas Bossaller³, Christian Schmidt-Lauber^1,4, Hani H. Abujudeh⁵, Gregory Vladimer³, Eicke Latz^3,6, Katherine A. Fitzgerald³, Ann Marshak-Rothstein¹ and Ellen M. Gravallese^1,7, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁴Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ⁵Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nephrogenic systemic fibrosis (NSF) is a progressive iatrogenic fibrosing disorder that develops in patients with chronic kidney disease following administration of gadolinium (Gd)-based contrast…
Abstract Number: 2613 • 2013 ACR/ARHP Annual Meeting
NF-κB Pathway Is Depleted In Phagocytes From Behçet´s Disease Patients Secondarily To Constitutive Phosphorylation Of The p65 Subunit
Sandro F. Perazzio^1,2, Paulo Vitor Soeiro Pereira³, Alexandre W.S. Souza^4,5, Antonio Condino-Neto³ and Luis Eduardo C. Andrade⁶, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Fleury Medicine and Health, Sao Paulo, Brazil, ³Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, ⁴University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁶Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: : Increased neutrophil activation has been previously shown in Behçet’s disease (BD) patients and it is unclear whether neutrophil activation occurs constitutively or if…
Abstract Number: 2347 • 2013 ACR/ARHP Annual Meeting
Functional Single Nucleotide Polymorphisms In The Interferon-γ and The NLRP3 (Cryopyrin) Genes Associated With Anti-TNF Response In Danish Rheumatoid Arthritis Patients
Jacob Sode^1,2,3, Niels H. H. Heegaard⁴, Henning Locht², Ulla Vogel⁵, Steffen Bank^6,7, Merete Lund Hetland^8,9 and Vibeke Andersen^3,7,10,11, ¹Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen S, Denmark, ²Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark, ³Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ⁴Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁵National Research Centre for the Working Environment, Copenhagen, Denmark, ⁶Institute of Human Genetics, University of Aarhus, Aarhus, Denmark, ⁷Medical Department, Viborg Regional Hospital, Viborg, Denmark, ⁸The Danish Rheumatologic Database (DANBIO), Glostrup Hospital, Glostrup, Denmark, ⁹Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ¹⁰Medical Department, Hospital of Southern Jutland Aabenraa, Aabenraa, Denmark, ¹¹Odense University Hospital, OPEN (Odense Patient data Explorative Network), Odense, Denmark
Background/Purpose: Most patients with rheumatoid arthritis (RA) benefit from tumor necrosis factor-a blocking treatment (anti-TNF). About 1/3, however, do not respond to this costly and…
Abstract Number: 1169 • 2013 ACR/ARHP Annual Meeting
A Novel Pro-Inflammatory Signaling Pathway Regulated By Follistatin-Like Protein 1
Yury Chaly¹, Anthony Marinov², Yu Fu², Brian Campfield², John Kellum³, Bruce Hostager⁴, Daniel Bushnell⁵, Yudong Wang², Jerry Vockley² and Raphael Hirsch⁶, ¹Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ²Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴University of Iowa Carver College of Medicine, Iowa City, IA, ⁵Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁶Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein produced mainly by cells of the mesenchymal lineage. The function of FSTL1 is still unclear, but…

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