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Abstracts tagged "inflammasome activation and uric acid"

  • Abstract Number: 2965 • ACR/ARHP Annual Meeting 2018

    Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation

    Anyan Cheng1, Roxana Coras1,2, Robert Terkeltaub3,4, Ru Liu-Bryan1,3 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3VA San Diego Healthcare System, San Diego, CA, 4Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA

    Background/Purpose: Emerging evidence indicates that macrophage activation is critically supported by glucose metabolic shifts. Although macrophages are key contributors to inflammation, little is known about…
  • Abstract Number: 1218 • ACR/ARHP Annual Meeting 2014

    The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice

    Yoshitaka Kimura1,2, Tamiko Yanagida3, Akiko Onda4, Hajime Kono2, Maki Takayama2, Kurumi Asako2, Akiko Okamoto2, Hirotoshi Kikuchi2 and Toshihiro Nanki5, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 3Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 4Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 5Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan

    Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…

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