Abstracts tagged "inflammasome activation and monocytes"

Abstract Number: 1164 • 2015 ACR/ARHP Annual Meeting
Four Types of Calcium Pyrophosphate Crystals Differentially Induce IL-1beta Production By Monocytes through ATP/Potassium Efflux/ROS Dependent Pathways
Laure Campillo-Gimenez¹, Pierre Gras², Félix Renaudin³, Marion Renaud³, Lorène Télot⁴, Amine Mellouk⁵, Pierre Bobé⁵, Jean-Michel Camadro⁴, Christèle Combes², Martine Cohen-Solal^3,6, Frederic Liote^3,6 and Hang-Korng Ea^3,6, ¹Hôpital Lariboisière, Centre Viggo Petersen, INSERM UMR1132, Paris Diderot University, Paris, France, ²ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ³INSERM UMR1132, Paris Diderot University, Paris, France, ⁴CNRS UMR7592, Jacques Monod Institute, Paris Diderot University, Paris, France, ⁵INSERM UMRS757, Paris Sud University, Orsay, France, ⁶AP-HP, Lariboisière Hospital, Rheumatology Department, Paris, France
Background/Purpose: Monoclinic and triclinic calcium pyrophosphate (m- and t-CPP) crystals are the 2 types of CPP crystals observed in human joints. Frequently asymptomatic, it can…

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