Abstracts tagged "Inflammasome activation and inflammation"

Abstract Number: 194 • ACR/ARHP Annual Meeting 2015
Events Upstream of Caspase-1 Activation in NLRP3-Mediated Cell Death in NOMID
Jehad H. Edwan, Raphaela Goldbach-Mansky and Robert A. Colbert, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Gain-of-function mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS), with neonatal-onset multisystem inflammatory disease (NOMID) being the…
Abstract Number: 614 • ACR/ARHP Annual Meeting 2014
The Association of PPM1A with Inflammasome Activation in Ankylosing Spondylitis
Soo Min Ahn¹, Seung-Hyeon Bae¹, Seokchan Hong¹, Eun-Ju Lee¹, Eun-Jin Lee², Eun-Ju Chang², Doo-Ho Lim¹, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
The Association of PPM1A with Inflammasome Activation in Ankylosing SpondylitisBackground/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disorder usually affecting axial skeleton and joints. The…
Abstract Number: 2741 • ACR/ARHP Annual Meeting 2013
Evidence That STAT3 controls NLRP3 inflammasome–dependent Release Of IL-1β and Pyronecrosis Through Regulation of mitochondrial activity
Jehad H. Edwan¹, Jae Jin Chae², Raphaela T. Goldbach-Mansky³ and Robert A. Colbert⁴, ¹NIAMS NIH, Bethesda, MD, ²Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁴NIAMS/NIH, Bethesda, MD
Background/Purpose: Self-activating NLRP3 mutations are responsible for cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID). Spontaneous…