Abstracts tagged "Infection"

Abstract Number: 1008 • ACR Convergence 2024
Immune Responses to Infection and Autoimmune Diseases in the UK Biobank
Choa Yun¹, May A. Beydoun², Lenore Launer² and Minkyo Song³, ¹National Institute on Aging, Rockville, MD, ²National Institute on Aging, Baltimore, MD, ³National Institutes on Aging, Baltimore, MD
Background/Purpose: Infections have been implicated as potential triggers for autoimmune responses, but studies primarily focused on the history of infection linked with autoimmune diseases. Large-scale…
Abstract Number: 2242 • ACR Convergence 2024
A Cross-sectional Study on Predictors of COVID-19 Infection, Admission and Mortality and Effect of Immunomodulating Treatments in Rheumatoid Arthritis
Mohammad Movahedi¹, Elliot Hepworth², Angela Cesta³, Xiuying Li³, Claire Bombardier⁴ and Sibel Aydin⁵, and OBRI investogators, ¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²University of Ottawa, Ottawa, ON, Canada, ³UHN, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Ottawa Hospital Research Institute, Ottawa, ON, Canada
Background/Purpose: COVID-19 infection frequently leads to a cytokine storm, which has successfully been treated with some immunomodulating therapies according to observational studies. Interestingly, treatments investigated…
Abstract Number: 0151 • ACR Convergence 2024
Immunoproteomic Profiling of Antibodies in Autoimmune Diseases
Choa Yun¹, Ji Qiu², M. Constanza Camargo³, Lusheng Song², Joshua LaBaer², Hyokyoung G. Hong³, Eric A. Engels³, Maddy Edie-Booker⁴, Adam Schiffenbauer⁵, Lisa Rider⁶, Frederick Miller⁷, Sarfaraz Hasni⁵, Blake M. Warner⁵, Mārcis Leja⁸ and Minkyo Song⁹, ¹National Institute on Aging, Rockville, MD, ²Arizona State University, Tempe, ³National Cancer Institute, Rockville, ⁴National Institute on Aging, Baltimore, MD, ⁵NATIONAL INSTITUTES OF HEALTH, Bethesda, MD, ⁶NIEHS, NIH, Garrett Park, MD, ⁷NIH, NIEHS, Chapel Hill, NC, ⁸University of Latvia, Rīga, Latvia, ⁹National Institutes on Aging, Baltimore, MD
Background/Purpose: Prior research has investigated a limited range of candidate markers within individual autoimmune diseases. This study aimed to identify specific and common autoantibodies and…
Abstract Number: 0262 • ACR Convergence 2024
Bartonella Endocarditis as an Important Mimic of ANCA Associated Vasculitis: Results of a Large Single Center Descriptive Analysis
Adam Brown¹, Adil Vural², Cassandra Calabrese³ and Leonard Calabrese², ¹Cleveland Clinic Foundation, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland Heights, OH
Background/Purpose: Infective Endocarditis (IE) is an important mimic of numerous forms of systemic vasculitis and especially Anti-Neutrophilic Cytoplasmic Antibody vasculitis (AAV). Bartonella endocarditis (BE) is…
Abstract Number: 1075 • ACR Convergence 2024
Optimizing Herpes Zoster Vaccination in Rheumatoid Arthritis Patients Ages 18-49 Years: A Quality Improvement Approach
Akhil Sood¹, Pegah Jahangiri¹, Christy Bill² and Janice Lin¹, ¹Stanford University, Palo Alto, CA, ²Stanford Health Care, Palo Alto, CA
Background/Purpose: Patients with rheumatoid arthritis are at increased risk for Herpes Zoster (HZ) infection, which is associated with increased hospitalizations and healthcare resource utilization. Despite…
Abstract Number: 2266 • ACR Convergence 2024
Immunosuppressive Medications and Common Infections in Patients with Rheumatoid Arthritis
Michael George¹, Kelly Gavigan², Shilpa Venkatachalam³, David Curtis², Laura Stradford⁴, William Benjamin Nowell⁵, Fenglong Xie⁶, Joshua Baker¹ and Jeffrey Curtis⁷, ¹University of Pennsylvania, Philadelphia, PA, ²Global Healthy Living Foundation, Upper Nyack, NY, ³Global Healthy Living Foundation, New York, NY, ⁴Global Healthy Living Foundation, Nyack, NY, ⁵Regeneron, New York, NY, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Hoover, AL
Background/Purpose: Patients with RA are at increased risk of serious infection, but less is known about common, non-serious infections. Our prospective study aimed to assess…
Abstract Number: 0236 • ACR Convergence 2024
Impact of Socioeconomic Status on Infection-Related Hospitalization Risk in Patients with Systemic Autoimmune Diseases
Ana Cecilia Bardan-Inchaustegui¹, Angel Kevin Garza-Elizondo², Pablo Gamez-Siller³, Jorge Esquivel-Valerio⁴, Jesus Cardenas-de la Garza¹, Diana Elsa Flores-Alvarado⁵, Daniela Alejandra Salcedo-Soto⁶, Karla Judith Duran-Villarreal⁷, Alejandra Jacquelin Osuna-Corrales⁷, Elsa Catalina Davila-Correa⁷, Valeria Cantu-Martinez⁷, Debanhi Morales-Espronceda⁷, Derek de Jesus Gauna-Leal⁷, Andrea Axelle Prado-Prado⁷, Nathalia Valdez-Benavides⁷, Nirvana Amairany González-Ontiveros⁷ and Dionicio Galarza-Delgado⁸, ¹Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, ²Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, San Nicolás de los Garza, Mexico, ³Facultad de Medicina UANL, Monterrey, Nuevo León, Mexico, ⁴Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, MONTERREY, Mexico, ⁵Hospital Universitario Jose Eleuterio Gonzalez, Monterrey, Nuevo León, Mexico, ⁶Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Mexico, ⁷Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Mexico, ⁸UANL Hospital Universitario, Monterrey, Nuevo León, Mexico
Background/Purpose: Socioeconomic status (SES) is associated with diseases and poor health outcomes, including delays in diagnosis and increased disease severity. Hospitalization, often due to infections,…
Abstract Number: 0263 • ACR Convergence 2024
Characteristics and Coinfections of Diffuse Alveolar Hemorrhage in Rheumatic Patients
Eduardo Briones-García¹, Shaul Navarro-Lara², Marco A Ortiz-Bustamante², Iris Paola García Herrera³, Carla M Roman-Montes² and Guillermo A Guaracha-Basañez⁴, ¹Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department., Ciudad de México, Distrito Federal, Mexico, ²Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador-Zubirán., México city, Mexico, ³Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁴Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubirán”, Mexico City, Distrito Federal, Mexico
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a severe respiratory complication observed in certain rheumatic diseases, such as systemic lupus erythematosus (SLE), ANCA-associated vasculitides (AAV), and…
Abstract Number: 1270 • ACR Convergence 2024
Association of Disease-Modifying Anti-Rheumatic Drug Selection with Hospitalized Infection in Youth with Childhood-Onset Systemic Lupus Erythematosus
Jordan Roberts¹, Anna Faino², Marshall Brown³, Gabrielle Alonzi⁴, Mersine Bryan⁵, Cordelia Burn⁶, Joyce Chang⁴, Jonathan Cogen⁷, Nidhi Naik⁸, Kareena Patel⁹, Emily Zhang⁴, Mary Beth Son¹⁰ and Esi Morgan¹, ¹Seattle Children's Hospital, Seattle, WA, ²Seattle Children's Research Institute, Core for Biostatistics, Epidemiology and Analytics in Research, Seattle, ³Core for Biostatistics, Epidemiology and Analytics in Research, Seattle Children's Research Institute, Seattle, WA, ⁴Boston Children's Hospital, Boston, MA, ⁵Division of Hospital Medicine, Seattle Children's Hospital, Seattle, WA, ⁶Seattle Children's Hospital, Boston Children's Hospital, Seattle, ⁷Seattle Children’s Hospital, Seattle, WA, ⁸Seattle children's hospital, Bothell, WA, ⁹Seattle Children's Hospital, Seattle, ¹⁰Boston Children's Hospital, Brookline, MA
Background/Purpose: Youth with childhood-onset systemic lupus erythematosus (cSLE) have increased risk of serious infection. It is unknown how much of this risk is due to…
Abstract Number: 2417 • ACR Convergence 2024
Frequency and Associated Factors of Herpes Zoster Infection in Systemic Lupus Erythematosus Patients from Latin-America
Romina Nieto¹, Lucia Hernandez², Marina Scolnik³, Gisela Constanza Subils⁴, Veronica Saurit⁵, Verónica Gabriela Savio⁶, Valeria Arturi⁷, Boris Kisluk⁸, Luciana González Lucero⁹, Wilfredo Patiño Grageda¹⁰, María De Los Ángeles Gargiulo¹¹, ODIRLEI MONTICIELO¹², Angela Duarte¹³, Eduardo Borba¹⁴, Luciana Parente¹⁴, Edgard Reis Neto¹⁵, Oscar Neira¹⁶, Gustavo Aroca Martínez¹⁷, Antonio Iglesias Gamarra¹⁸, Paul Méndez-Patarroyo¹⁹, Rafael López²⁰, Margarita Portela Hernandez²¹, Carlos Núñez-Álvarez²², Yelitza González Bello²³, Jorge Isaac Velasco Santos²⁴, Jorge Esquivel-Valerio²⁵, Marcos Vázquez²⁶, Maria Teresa Martinez de Filartiga²⁷, Magaly Alva Linares²⁸, Roberto Muñoz Louis²⁹, Carina Pizzarossa³⁰, Ana Carolina Ralle³¹, María Camila Riascos³², Joaquín Martínez Serventi³³, Graciela Alarcon³⁴, Bernardo Pons-Estel² and Guillermo Pons-Estel³⁵, and Grupo Latinoamericano de Estudio del Lupus (GLADEL), ¹Centro Regional de Enfermedades Autoinmunes y Reumaticas. GO-CREAR, Rosario, Santa Fe, Argentina, ²Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), ROSARIO, Santa Fe, Argentina, ³Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Hospital Italiano de Córdoba, Córdoba, Argentina, ⁵hospital privado universitario de cordoba, Córdoba, Argentina, ⁶Sección de Reumatología, Hospital Córdoba, Córdoba, Argentina, ⁷Hospital HIGA San Martín, La Plata, Argentina, ⁸Unidad de Enfermedades Autoinmunes, Hospital Escuela Eva Perón, Granadero Baigorria, Argentina, ⁹Hospital Padilla, Tucumán, Argentina, ¹⁰Hospital General de Agudos Dr Ramos Mejia, CABA, Argentina, ¹¹Instituto de Investigaciones Médicas Alfredo Lanari, Buenos Aires, Argentina, Buenos Aires, Argentina, ¹²HOSPITAL DE CLINICAS DE PORTO ALEGRE, PORTO ALEGRE, Rio Grande do Sul, Brazil, ¹³Universidad Federal de Pernambuco, Pernambuco, Brazil, ¹⁴Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, ¹⁵Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal, São Paulo, SP, Brazil, ¹⁶Hospital del Salvador, Santiago de Chile, Chile, ¹⁷Universidad Simón Bolivar, Barranquilla, Colombia, Barranquilla, Colombia, ¹⁸Clínica de La Costa - Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia, ¹⁹Universidad de Los Andes, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia, ²⁰Servicio de Reumatología. Hospital Luís Vernaza, Guayaquil, Ecuador, Guayaquil, Ecuador, ²¹Departamento de Reumatología del Hospital de especialidades del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social (IMSS), Mexico, Mexico, ²²Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico, Mexico, Mexico, ²³Depto. de Inmunología y Reumatología, Hospital General de Occidente y Universidad de Guadalajara, Guadalajara, Mexico, ²⁴Hospital Central Dr. Ignacio Morones Prieto, Potosí, Mexico, ²⁵Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, MONTERREY, Mexico, ²⁶Hospital de Clínicas I, Asunción, Paraguay, Asuncion del Paraguay, Paraguay, ²⁷Dpto de Reumatología Hospital de Clínicas. Facultad de Ciencias medicas.Universidad Nacional de Asunción, Asuncion del Paraguay, Paraguay, ²⁸Servicio de Reumatologia. Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru, ²⁹Hospital Docente Padre Billini, Santo Domingo, República Dominicana, Santo Domingo, Dominican Republic, ³⁰Clínica Médica C, Hospital de Clínicas, UDELAR, Montevideo, Uruguay, ³¹Hospital Señor del Milagro, Salta, Argentina, ³²Centro de Referencia en Osteoporosis & Reumatología, Cali, Colombia, ³³Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina, CABA, Argentina, ³⁴The University of Alabama at Birmingham, Oakland, CA, ³⁵Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, ROSARIO, Santa Fe, Argentina
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with complex multi-systemic involvement. Herpes zoster (HZ) is caused by the reactivation of latent varicella-zoster virus…
Abstract Number: 0237 • ACR Convergence 2024
Tofacitinib: A Retrospective Study on Safety and Adverse Effects
Vrushal Kale¹, Sandeep yadav², Canchi Balakrishnan³, Rohini Samant⁴, Bishakha Swain⁴, Shaurav Khanna⁵, Aashish Agrawal⁵ and Aditi Patankar⁴, ¹P D Hinduja national Hospital and medical Research centre, Mumbai, Maharashtra, India, ²Pd Hinduja hospital, Thane, Maharashtra, India, ³P D Hinduja Hospital and Medical Research Centre, Mahim, Mumbai, Mahin, Maharashtra, India, ⁴P D Hinduja Hospital and Medical Research Centre, Mumbai, mumbai, Maharashtra, India, ⁵P D Hinduja Hospital and Medical Research Centre, Mahim, Mumbai, Mumbai, Maharashtra, India
Background/Purpose: Tofacitinib, an oral Janus kinase inhibitor, is widely used in India to treat rheumatoid arthritis (RA) and other autoimmune diseases. Although its efficacy is…
Abstract Number: 0264 • ACR Convergence 2024
Clinical Value of Metagenomic Next-generation Sequencing in Patients with Connective Tissue Disease Co-infections: A Single-center Study from Southern Hospital in China
Yuan-Yuan Xiao¹, Ai-Ling Lu¹, Han-You Mo², Zhen-Dong He², Jia-Le Wen² and Xuan Yin¹, ¹Guilin Medical University, Guilin, China (People's Republic), ²The First Affiliated Hospital of Guangxi Medical University, Nanning, China (People's Republic)
Background/Purpose: Few studies have been reported on the use of metagenomic next-generation sequencing (mNGS) in patients with connective tissue disease (CTD) co-infections, and more relatively large-scale data…
Abstract Number: 1338 • ACR Convergence 2024
Health Care Utilization and Cost of Herpes Zoster Infection in Patients with Rheumatoid Arthritis, a Retrospective Cohort Study
Mohammad Movahedi¹, Angela Cesta², Xiuying Li², Mark Tatangelo³ and Claire Bombardier³, and OBRI investigators, ¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Patients with rheumatoid arthritis (RA) have approximately a twofold increased risk of developing herpes zoster (HZ) compared to the general population. This elevated risk is attributed…
Abstract Number: 2433 • ACR Convergence 2024
Sequential Pneumococcal Vaccination in SLE: Immunogenicity, Side Effects and Comparison with PPSV23 Vaccination
Rudrarpan Chatterjee¹, Sai Yasaswini Kommaraju², Shincy MR³ and Amita Aggarwal⁴, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow., Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, ³Central research lab, Kampewgowda Institute of Medical Sciences, Bengaluru, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India
Background/Purpose: SLE patients have increased risk of invasive pneumococcal disease due to immune dysregulation and drugs used in these patients. EULAR 2019 recommendation suggest sequential…
Abstract Number: 0238 • ACR Convergence 2024
Longitudinal Assessment of CD8+ T Cell Responses to SARS-CoV-2 Pre- and Post-breakthrough Infection and Its Association with COVID-19 Severity in Immunosuppressed Individuals
Aljawharah Alrubayyi¹, Aaron Shulkin¹, Judith James², Meggan Mackay³, Dinesh Khanna⁴, Amit Bar-Or⁵, Susan Macwana⁶, Ellen Goldmuntz⁷, James McNamara⁸, Sean McCarthy⁹, Matthew Sherman⁸, William Barry¹⁰, Ashley Pinckney¹¹, Sarah Walker¹⁰, Sara Tedeschi¹², Jeffrey Sparks¹³, Zachary Wallace¹⁴ and Gaurav Gaiha¹⁵, ¹Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Feinstein Institutes for Medical Research, Manhasset, NY, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Oklahoma Medical Research Foundation, Oklahoma City, ⁷NIAID/ NIH, Washington, DC, ⁸NIH, Bethesda, MD, ⁹DAIT/NIAID/NIH, Rockville, MD, ¹⁰Rho, Durham, NC, ¹¹Rho, St Louis Park, NC, ¹²Brigham and Women's Hospital, Boston, MA, ¹³Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, ¹⁴Massachusetts General Hospital, Newton, MA, ¹⁵Massachusetts General Hospital, Boston, MA
Background/Purpose: Vaccines for SARS-CoV-2 have greatly reduced COVID-19 morbidity and mortality through the induction of neutralizing antibody responses. However, T cell responses are also induced…

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