Abstracts tagged "infection and inflammasome activation"

Abstract Number: 942 • ACR/ARHP Annual Meeting 2017
Role of the Pyrin Inflammasome in Resistance to Yersinia Pestis: A Possible Selective Advantage for Carriers of MEFV Mutations
Yong Hwan Park¹, Wonyong Lee¹, Lawton Chung², James Bliska², Daniel L. Kastner¹ and Jae Jin Chae³, ¹Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY, ³Inflammatory disease section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Mutations in MEFV, encoding pyrin, cause the prototypic autoinflammatory disease, familial Mediterranean fever (FMF). The carrier frequency of FMF-associated MEFV mutations is extraordinarily high…