Abstracts tagged "Immunotherapy"

Abstract Number: 116 • 2017 ACR/ARHP Annual Meeting
Immunotherapy-Induced Rheumatic Disease: How Prepared Are Rheumatologists to Address This Emerging Condition?
Laura Cappelli^1,2, Cassandra Calabrese³, Leonard H. Calabrese³ and Clifton O. Bingham III⁴, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, OH, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Cancer immunotherapy targeting immune checkpoints represents a major advance in oncology, yet has been associated with immune-related adverse events (IRAEs) affecting many organ systems,…
Abstract Number: 850 • 2017 ACR/ARHP Annual Meeting
Immune Checkpoint Inhibitors and Inflammatory Myopathies: Data from the US Food and Drug Administration Adverse Event Reporting System
Xerxes Pundole, Mohsin Shah, Noha Abdel-Wahab and Maria Suarez-Almazor, Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX
Background/Purpose: Immune checkpoint inhibitors have become standard of care for many malignancies. Although these therapies are effective, they can activate the immune system resulting in…
Abstract Number: 1148 • 2017 ACR/ARHP Annual Meeting
Arthritis after Cancer Immunotherapy: Symptom Duration and Treatment Response
Melanie H. Smith¹ and Anne R. Bass^2,3, ¹Medicine, New York Presbyterian Hospital (Cornell), New York, NY, ²Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ³Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY
Background/Purpose: Checkpoint inhibitor immunotherapy has fundamentally changed the treatment for an actively expanding list of cancers, however its use is associated with immune related adverse…
Abstract Number: 1156 • 2017 ACR/ARHP Annual Meeting
Rheumatic Immune Related Adverse Events from Checkpoint Inhibitor Therapy for Cancer: Long-Term Follow up Data
Cassandra Calabrese¹, Elizabeth Kirchner¹, Apostolos Kontzias¹, Laura Wood², Brian Rini², Vamsidhar Velcheti² and Leonard H. Calabrese¹, ¹Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, OH, ²Hematology and Oncology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: The new and emerging field of immune related adverse events (irAEs) from cancer immunotherapies presents many unanswered questions. The spectrum of irAEs is broad…
Abstract Number: 1173 • 2017 ACR/ARHP Annual Meeting
Rheumatic Immune Related Adverse Events Due to Programmed Cell Death Protein 1 (PD-1) Inhibition for Cancer: Comprehensive Analysis of a Whole Cancer Cohort
David Liew^1,2,3, Jessica Leung¹, Bonnia Liu¹, Jonathan Cebon^3,4, Albert Frauman^2,3 and Russell Buchanan¹, ¹Department of Rheumatology, Austin Health, Melbourne, Australia, ²Department of Clinical Pharmacology and Therapeutics, Austin Health, Melbourne, Australia, ³Department of Medicine, University of Melbourne, Melbourne, Australia, ⁴Olivia Newton-John Cancer Wellness & Research Centre, Melbourne, Australia
Background/Purpose: Immune checkpoint therapy with programmed cell death protein 1 (PD-1) inhibitors has led to significant survival benefits in the treatment of multiple cancers. This…
Abstract Number: 1462 • 2017 ACR/ARHP Annual Meeting
Induction of Immune Tolerance through an Epitope-Specific Vaccine Induces Clinical Amelioration in Patients with Rheumatoid Arthritis
Jin Hui Sherlynn Chan¹, Theodorus van den Broek², Jing Yao Leong¹, Maura Rossetti³, Roberto Spreafico⁴ and Salvatore Albani^1,5, ¹SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²University Medical Center of Utrecht, Utrecht, Netherlands, ³University of California, Los Angeles, Los Angeles, CA, ⁴Synthetic Genomics, La Jolla, CA, ⁵KK Women's and Children's Hospital, Singapore, Singapore
Background/Purpose: The manipulation of immune tolerance using immune checkpoints such as PD-1 is gaining progressive attraction in diseases such cancer where such manipulation would be…
Abstract Number: 1741 • 2017 ACR/ARHP Annual Meeting
Tolerance and Efficiency of Anti-Programmed Death 1 Antibodies in Patients with Cancer and Preexisting Autoimmune or Inflammatory Diseases
Francois-Xavier Danlos¹, Anne-Laure Voisin², Valérie Dyevre³, Jean-Marie Michot¹, Emilie Routier⁴, Laurent Taillade⁵, Stéphane Champiat¹, Sandrine Aspeslagh¹, Julien Haroche⁶, Laurence Albiges⁷, Christophe Massard¹, Nicolas Girard⁸, Stéphane Dalle⁹, Benjamin Besse⁷, Salim Laghouati², Jean-Charles Soria¹, Christine Mateus⁴, Caroline Robert⁴, Emilie Lanoy³, Aurélien Marabelle^1,10 and Olivier Lambotte¹¹, ¹Drug Development Department, Gustave Roussy Institut, Villejuif, France, ²Unité Fonctionnelle de Pharmacovigilance, Gustave Roussy Institut, Villejuif, France, ³Service de biostatistique et d’épidémiologie, Gustave Roussy Institut, Villejuif, France, ⁴Department of dermatology, Gustave Roussy Institut, Villejuif, France, ⁵Department of medical oncology, Pitié Salpétrière Hospital, Paris, France, ⁶Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ⁷Department of medical oncology, Gustave Roussy Institut, Villejuif, France, ⁸8. Department of Respiratory Medicine, National Expert Centre for Thymic Malignancies, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France, ⁹Department of dermatology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France, ¹⁰Immunotherapy program, Gustave Roussy Institut, Villejuif, France, ¹¹Internal Medicine, Hopital Kremlin Bicêtre, Kremlin Bicêtre, France
Background/Purpose: Patients with auto-immune or inflammatory diseases (AID) treated by immune check-points inhibitors (ICI) are intrinsically susceptible to develop immune related adverse events (irAE). We…
Abstract Number: 1880 • 2017 ACR/ARHP Annual Meeting
Cancer Immunotherapy in Patients with Preexisting Rheumatologic Disease: The Mayo Clinic Experience
Michael Richter¹, Olga Pinkston², Lisa Kottschade³, Heidi Finnes³, Svetomir N. Markovic⁴ and Uma Thanarajasingam⁵, ¹Internal Medicine, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic Florida, Jacksonville, FL, ³Oncology, Mayo Clinic, Rochester, MN, ⁴Department of Medicine and Oncology, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Immune checkpoint inhibitors have revolutionized the treatment of advanced malignancies. By blocking T-cell inhibition these drugs result in immune targeting of tumor cells and…
Abstract Number: 2119 • 2017 ACR/ARHP Annual Meeting
Rheumatological Immune Related Adverse Events in Malignancy Patients Treated with Anti-Programmed Cell Death (PD) 1 Antibodies
Emma Mitchell¹, Peter Lau², Chloe Khoo², Kortnye Smith², Benjamin Brady², Mark Shackleton², Grant McArthur², Ian Wicks^1,3,4 and Shahneen Sandhu², ¹Rheumatology, Royal Melbourne Hospital, Melbourne, Australia, ²Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia, ³Medicine, University of Melbourne, Melbourne, Australia, ⁴Wicks Lab, Walter and Eliza Hall Institute, Melbourne, Australia
Background/Purpose: Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 (anti-PD 1) antibodies, are established therapies for advanced malignancies, including melanoma, and non-small cell lung…
Abstract Number: 2155 • 2017 ACR/ARHP Annual Meeting
Myositis As a Complication of Checkpoint Blockade at a Comprehensive Cancer Center
Mohsin Shah¹, Jean Tayar¹, Noha Abdel-Wahab^1,2 and Maria Suarez-Almazor¹, ¹Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, ²Rheumatology and Rehabilitation Department, Assiut University Hospitals, Assiut, Egypt, Assiut, Egypt
Background/Purpose: Immune checkpoint inhibitor therapy (ICI) has surfaced as a successful and robust treatment option in the fight to end cancer. As we gain more…
Abstract Number: 2702 • 2017 ACR/ARHP Annual Meeting
Tissue-Invasive T Cells in Rheumatoid Arthritis
Cornelia M. Weyand¹, Yi Shen², Yinyin Li¹, Eric L. Matteson³, Stuart Goodman⁴ and Jorg Goronzy⁵, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Orthopaedic Surgery, Stanford Medical Center Outpatient Clinic, Redwood City, CA, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: A key pathogenic event in rheumatoid arthritis (RA) is the formation of lasting lymphoid microstructures in the synovial tissue. It requires the transmigration of…
Abstract Number: 13L • 2016 ACR/ARHP Annual Meeting
Low-Dose IL-2 Therapy in Refractory SLE: Results from Single Center Phase I/IIa Clinical Trial
Jens Humrich¹, Caroline von Spee-Mayer², Elise Siegert³, Angelika Rose², Martina Bertolo⁴, Philipp Enghard⁵, Falk Hiepe⁶, Tobias Alexander⁷, Eugen Feist⁸, Andreas Radbruch⁹, Gerd R. Burmester¹⁰ and Gabriela Riemekasten¹¹, ¹Department of Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ²Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ⁴Department of Rheumatology, Charité – University Medicine Berlin, Berlin, Germany, ⁵Department of Nephrology, Charité – University Medicine Berlin, Berlin, Germany, ⁶Charité – Universitätsmedizin, Berlin, Germany, ⁷Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ⁸Charité-Universitätsmedizin Berlin, Berlin, Germany, ⁹Deutsches Rheumaforschungszentrum, Berlin, Germany, ¹⁰Charité – University Medicine Berlin, Berlin, Germany, ¹¹Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany

Background/Purpose: Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies…
Abstract Number: 1339 • 2016 ACR/ARHP Annual Meeting
Rheumatic Immune Related Adverse Events of Checkpoint Therapy for Cancer: Case Series of a New Nosologic Entity
Cassandra Calabrese¹, Apostolos Kontzias¹, Vamsidhar Velcheti² and Leonard H. Calabrese¹, ¹Rheumatic & Immunologic Disease, Cleveland Clinic, Cleveland, OH, ²Hematology and Oncology, Cleveland Clinic, Cleveland, OH
Background/Purpose: The introduction of immunotherapy with biologic agents targeting immunologic checkpoints (i.e. CTLA4 and PD-1/PDL-1) have yielded impressive gains for cancer patients. These agents…
Abstract Number: 2934 • 2016 ACR/ARHP Annual Meeting
Clinical Assessment of the Monoclonal Anitbody, PRX003, a Potential Novel Treatment for Th17-Mediated Inflammatory Disease
Gene G. Kinney¹, Kenneth Flanagan¹, Michael Skov¹, Ronald Goldblum², Sue Griffith³, Robin M. Barbour¹, Wagner Zago¹, Ted Yednock¹, Martin Koller¹ and Dan Ness¹, ¹Prothena Biosciences Inc, South San Francisco, CA, ²Carlsbad Pharmaceutical Consulting, Inc., Carlsbad, CA, ³ClinPharma Services, Inc, San Diego, CA
Background/Purpose: Melanoma cell adhesion molecule (MCAM; CD146) is expressed on the surface of Th17 cells, which have the capacity to produce IL-17 and a multitude…
Abstract Number: 2837 • 2014 ACR/ARHP Annual Meeting
Induction of Clinical Remission By Low-Dose Interleukin-2 in Refractory SLE
Jens Y. Humrich¹, Caroline von Spee-Mayer¹, Elise Siegert¹, Angelika Rose¹, Tobias Alexander², Falk Hiepe¹, Andreas Radbruch³, Gerd Burmester⁴ and Gabriela Riemekasten¹, ¹Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³German Rheumatism Research Centre Berlin (DRFZ), an institute of the Leibniz Association, Berlin, Germany, ⁴Charité University Medicine, Dept. Medicine/Rheumatology and Clinical Immunology, Berlin, Germany
Background/Purpose Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies…

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