Abstracts tagged "Immunological Synapse"

Abstract Number: 3021 • 2015 ACR/ARHP Annual Meeting
The Adaptor Protein Crkii Regulates Rap1 Activation in the Immunological Synapse
Adam Mor¹ and Inbar Alfaguter², ¹Rheumatology and Pathology, NYU Langone Medical Center, New York, NY, ²NYU, New York, NY
Background/Purpose: Crk proteins are a family of adaptors that play an important role in regulating multiple T cell functions. The two main Crk isoforms are…
Abstract Number: 725 • 2013 ACR/ARHP Annual Meeting
Localization At The Immunological Synapse Of Adaptor Protein Grb2 and PLC Gamma-1 In Non-Stimulated Peripheral Blood T Lymphocytes From Patients With Systemic Lupus Erythematosus Suggests An In Vivo dysregulated Activation State
Nursamaa Abdoel¹, Mireyma Sanchez², Hector Rojas³, Martin Rodriguez⁴ and Ana M. Blasini¹, ¹Sección de Investigación en Inmunoreumatologia, Hospital Universitario de Caracas, Caracas, Venezuela, ²Rheumatology, Hospital Universitario de Caracas, Caracas, Venezuela, ³Instituto de Inmunologia, Escuela de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, ⁴Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Caracas, Venezuela
Background/Purpose: We previously showed an increased metabolic rate of transmembrane adaptor protein LAT in TCR/CD3 stimulated lupus T cells, associated with delocalization of this adaptor…

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