Abstracts tagged "Immunoglobulin (IG)"

Abstract Number: 1715 • 2016 ACR/ARHP Annual Meeting
ABT-122, an Immunoglobulin Targeting Both TNF-α and IL-17A, Does Not Provide Significantly Greater Efficacy Compared with Adalimumab in Subjects with Psoriatic Arthritis: Results from Exposure-Response Analyses
Ben Klunder¹, Amit Khatri², Mukul Minocha³, Paul Peloso⁴ and Ahmed A. Othman², ¹AbbVie, Ludwigshafen am Rhein, Germany, ²AbbVie Inc., North Chicago, IL, ³Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, IL, ⁴AbbVie, North Chicago, IL
Background/Purpose: ABT-122 is a novel dual-variable domain immunoglobulin (DVD-IgTM), which specifically neutralizes both TNF alpha (TNFα) and interleukin-17A (IL-17). Drugs individually neutralizing TNFα or IL-17…
Abstract Number: 2329 • 2016 ACR/ARHP Annual Meeting
Intravenous Immunoglobulins in the Treatment of Idiophatic Inflammatory Myopathies: Where Do We Stand?
Simone Barsotti^1,2, Elisa Cioffi¹, Alessandra Tripoli¹, Emanuele Calabresi¹, Antonio Gaetano Tavoni³, Anna d'Ascanio¹, Rossella Neri⁴ and Marta Mosca¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²University of Siena, Department of Medical Biotechnologies, Siena, Italy, ³Immunoallergology Unit, University of Pisa, Pisa, Italy, ⁴Rheumatology Unit, University of Pisa, PISA, Italy
Background/Purpose: several data are available about the use of IvIg in the treatment of idiopathic inflammatory myopathies (IIM), but the results derive from small cohorts.…
Abstract Number: 2844 • 2016 ACR/ARHP Annual Meeting
Immunoglobulins Level and Risk of Infection in Systemic Lupus Erythematosus
Ibrahim Almaghlouth¹, Jiandong Su², Dafna D Gladman³ and Murray Urowitz⁴, ¹Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Patients with SLE have been followed prospectively at 2-6 month intervals according to a standard protocol, which includes detailed clinical and laboratory assessments including…
Abstract Number: 3165 • 2016 ACR/ARHP Annual Meeting
HLA-B27 Expression Is Accompanied By a Profoundly Altered IgA Response to the Intestinal Microbiota and Microbial Translocation to the Joint
Mark Asquith¹, Sean Davin¹, Patrick Stauffer¹, Claire Mitchell² and James T. Rosenbaum¹, ¹Oregon Health & Science University, Portland, OR, ²Division of Arthritis and Rheumatology, Oregon Health & Science University, Portland, OR
Background/Purpose: HLA-B27 is the strongest known genetic risk factor for ankylosing spondylitis and other spondyloarthropathies (SpAs). We have shown previously that Fisher 344 rats that…
Abstract Number: 469 • 2014 ACR/ARHP Annual Meeting
Safety of Rituximab in Patients with Chronic Inflammatory Arthritis. Seven-Year Follow-up Observational Study
Andrea Cuervo¹, M. Victoria Hernández¹, Sonia Cabrera¹, Jose Inciarte-Mundo¹, Julio Ramirez¹, Virginia Ruiz-Esquide¹, Juan D. Cañete² and Raimon Sanmarti¹, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clinic, Barcelona, Spain
Background/Purpose: Rituximab (RTX) is a biologic therapy approved for the treatment of active rheumatoid arthritis (RA) refractory to tumour necrosis factor antagonists. It causes B…
Abstract Number: 2639 • 2013 ACR/ARHP Annual Meeting
Long-Term Outcome of Monoclonal (type 1) Cryoglobulinemia
Antoine Néel¹, François Perrin¹, Olivier Decaux², Thomas Dejoie³, Maxime Halliez³, Béatrice Mahé⁴, Thierry Lamy⁵, Fadi Fakhouri⁶, Patrick Jego², Christian Agard¹, Cécile Vigneau⁷, Lucienne Guenet⁸, Bernard Grosbois⁹, Philippe Moreau⁴ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Department of Internal Medicine, Rennes University Hospital, Rennes, France, ³Biochemistry Laboratory, Nantes University Hospital, Nantes, France, ⁴Hematology, Nantes University Hospital, Nantes, France, ⁵Hematology, Rennes University Hospital, Rennes, France, ⁶Nephrology, Nantes University Hospital, Nantes, France, ⁷Nephrology, Rennes University Hospital, Rennes, France, ⁸Biochemistry Laboratory, Rennes University Hospital, Rennes, France, ⁹Internal Medicine Department, Rennes University Hospital, Rennes, France
Background/Purpose: To investigate long-term outcome of symptomatic type 1 cryoglobulinemia and its determinants. Methods: Retrospective analysis of a prospective cohort from 2 French university hospitals.…
Abstract Number: 2342 • 2013 ACR/ARHP Annual Meeting
Long-Term Safety Of Rituximab: Pooled Analysis Of The Rheumatoid Arthritis Global Clinical Trial Program Over 11 Years
Ronald van Vollenhoven¹, Paul Emery^2,3, Clifton O. Bingham III⁴, Edward Keystone⁵, Roy Fleischmann⁶, Daniel Furst⁷, Eva W. Hessey⁸, Abdul Mehbob⁸ and Patricia B. Lehane⁹, ¹Karolinska Institute, Stockholm, Sweden, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵University of Toronto, Toronto, ON, Canada, ⁶University of Texas Southwestern Medical Center, Dallas, TX, ⁷Medicine, University of California, Los Angeles, Los Angeles, CA, ⁸Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁹Roche Products Ltd, Welwyn Garden City, United Kingdom
Background/Purpose: This analysis evaluated the long-term safety of rituximab (RTX) in rheumatoid arthritis (RA) patients in a global clinical trial program. Methods: Pooled observed case…
Abstract Number: 1892 • 2013 ACR/ARHP Annual Meeting
High-Throughput Immunoglobulin G Fab Glycosylation Profiling Reveals Differential Glycosylation On Fab and Fc
Albert Bondt^1,2, Yoann Rombouts³, Maurice H.J. Selman¹, Radboud JEM Dolhain⁴ and Manfred Wuhrer¹, ¹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands
Background/Purpose: Rheumatoid arthritis is known to improve during pregnancy, and a flare of disease activity is observed after delivery (1). N-glycosylation of the constant region…
Abstract Number: 2262 • 2012 ACR/ARHP Annual Meeting
Hypogammaglobulinemia in Pediatric Systemic Lupus Erythematosus
Emilina Lim¹ and Megan A. Cooper², ¹Pediatric Rheumatology, Washington University in Saint Louis- St. Louis Children's Hospital, St. Louis, MO, ²Pediatrics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: : Systemic lupus erythematosus (SLE) is characterized by B cell activation, elevated serum IgG and prominent circulating immune complexes. However, hypogammaglobulinemia in SLE patients…
Abstract Number: 1920 • 2012 ACR/ARHP Annual Meeting
Spectrum of IgG4-Related Disease and Diagnostic Value of Serum IgG4 Determinations
Emma Kotisalmi¹, Tom Pettersson², Aaro Miettinen³, Johanna Arola⁴ and Martti Färkkilä⁵, ¹Department of Medicine, University of Helsinki, Helsinki, Finland, ²Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, ³Department of Immunology, Huslab, Helsinki, Finland, ⁴Department of Pathology, University of Helsinki and Huslab, Helsinki, Finland, ⁵Department of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
Background/Purpose: IgG4-related disease is a recently described systemic inflammatory and fibrosing condition that may mimic various other systemic rheumatic diseases. We studied the occurrence of…
Abstract Number: 1921 • 2012 ACR/ARHP Annual Meeting
Diagnostic Utility of Serum IgG4 in IgG4-Related Disease
Mollie Carruthers¹, Tamara Augustin², John H. Stone¹ and Arezou Khosroshahi¹, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Internal Medicine, Internal Medicine, Northshore Medical Center, Salem, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disease with multi-organ system involvement, often but not always characterized by elevated serum IgG4 concentrations. The…
Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting
The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations
Annemiek Willemze, Jing Shi, Marlies Mulder, Gerrie Stoeken-Rijsbergen, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…
Abstract Number: 1336 • 2012 ACR/ARHP Annual Meeting
Changes in the Levels of Anti-Cyclic Citrullinated Protein Antibody and Immunoglobulins in Rheumatoid Arthritis Patients After Administration of Tocilizumab
Masao Sato¹, Masao Takemura², Ryuki Shinohe³, Tsuneo Watanabe² and Katsuji Shimizu³, ¹Rheumatology, Matsunami General Hospital, Gifu, Japan, ²Informative Clinical Medicine, Gifu University, Gifu, Japan, ³Orthopaedic Surgery, Gifu University, Gifu, Japan
Background/Purpose: The recently established scoring system of American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) early arthritis diagnosis criteria have assigned scores of 0, 1,…
Abstract Number: 1176 • 2012 ACR/ARHP Annual Meeting
Galactosylation, and Not Sialylation, of Immunoglobulin G Is Associated with Improvement of Rheumatoid Arthritis During Pregnancy
Albert Bondt¹, Maurice H.J. Selman², André M. Deelder³, Johanna M.W. Hazes¹, Manfred Wuhrer² and Radboud J.E.M. Dolhain¹, ¹Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ²Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ³Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is known to improve during pregnancy and to flare after delivery [1]. Changes in the glycosylation of immunoglobulin G’s fragment crystallizable…

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