Abstracts tagged "immunoglobulin (IG) and osteoclastogenesis"

Abstract Number: 20 • 2012 ACR/ARHP Annual Meeting
Osteoclastogenesis Is Inhibited by Immune Complexes Through Activating Fcγ Receptors
Lilyanne C. Grevers¹, Peter L.E.M. van Lent², Teun J. de Vries³, Vincent Everts³, J. Sjef Verbeek⁴ and Wim B. van den Berg⁵, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Oral Cell Biology, ACTA, UVA, VU University Amsterdam, Amsterdam, Netherlands, ⁴Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Rheumatoid arthritis is characterized by chronic inflammation and osteoclast-mediated bone loss. Co-stimulatory signalling via ITAM- and ITIM-coupled receptors is essential for osteoclast formation and…

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