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Abstracts tagged "immunoglobulin (IG) and citrullination"

  • Abstract Number: 482 • ACR/ARP Annual Meeting 2019

    Antibody Repertoire Sequencing, Antigen Array Analysis, and Cytokine Profiling of Blood from Individuals at High-risk for RA Reveals Candidate Immunoglobulin V Genes, ACPA, and Cytokines That May Promote the Transition to Arthritis

    Radhika Iyer1, Amin Zia 1, Michelle Bloom 1, Sunil Nagpal 2, Navin Rao 2, Frédéric Baribaud 3, George Vratsanos 4, Wei Wang 5, Gary Firestein 6, David Boyle 5, Jane Buckner 7, V. Michael Holers 8, Kevin Deane 9 and William Robinson 10, 1Stanford University, Stanford, 2Janssen R&D, Spring House, PA, 3Janssen Research & Development, LLC, Spring House, PA, 4JNJ, Raritan, NJ, 5University of California, San Diego, San Diego, CA, 6University of California, San Diego, San Diego, 7Benaroya Research Institute, Seattle, WA, 8University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 9University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 10Stanford University, Stanford, CA

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated…

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