Abstracts tagged "immunity"

Abstract Number: 384 • 2017 ACR/ARHP Annual Meeting
Protection Against Hepatitis B in Immunocompromised Pediatric Rheumatology and Gastroenterology Patients
Najla Aljaberi¹, Emily A. Smitherman², Enas Ghulam³, Allen Watts², Dana MH Dykes⁴ and Jennifer L. Huggins⁵, ¹Pediatric rheumatology, Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Environmental health and biostatistics, Department of Environmental Health, University of Cincinnati, Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁴Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Hepatitis B infection remains a significant public health challenge, particularly for patients on chronic immunosuppressive therapy, due to a considerable mortality risk associated with…
Abstract Number: 757 • 2017 ACR/ARHP Annual Meeting
Plasmacytoid Dendritic Cells Activated through TLR8 Promote Systemic Sclerosis
Marie-Dominique Ah Kioon¹, Claudio Tripodo², Alexandra Morquette³, Robert F. Spiera³, Jessica K. Gordon³ and Franck J. Barrat¹, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Department of Health Science, Human Pathology, tumor immunology unit, Palermo, Italy, ³Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Plasmacytoid Dendritic Cells (PDCs) are the key cell type mediating TLR-induced inflammation in several autoimmune diseases such as lupus, dermatomyositis, lichen sclerosus and cutaneous…
Abstract Number: 2415 • 2017 ACR/ARHP Annual Meeting
Immunogenicity and Persistence of a Prime-Boost Re-Vaccination Strategy for Pneumococcal Vaccines (13-Valent Pneumococcal Conjugate Vaccine + 23-Valent Pneumococcal Polysaccharide Vaccine) in Patients with Rheumatoid Arthritis: A Pilot Study
Mathilde Bahuaud¹, Constance BEAUDOUIN², Anna Molto³, Odile Launay⁴, Frederic Batteux⁵ and Maxime Dougados⁶, ¹Université Paris Descartes, Sorbonne Paris Cité AP-HP, Département d’Immunologie Biologique, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Paris, France, Paris, France, ²Cochin Hospital, APHP, Rheumatology B, Paris, France, ³Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁴Université Paris Descartes, Sorbonne Paris Cité AP-HP, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Fédération d'Infectiologie, Paris, France; Inserm, F-CRIN I-REIVAC., Paris, France, ⁵Immunology, APHP Hopital Cochin, Paris, France, ⁶Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk of some serious vaccine-preventable infections, like Pneumococcal infections. Since 2013, French vaccine recommendations committee…
Abstract Number: 2700 • 2017 ACR/ARHP Annual Meeting
Fra-2 Overexpression Leads to Systemic Autoimmunity By Affecting IL2 Dependent Treg Homeostasis
Florian Renoux¹, Mara Stellato¹, Daniela Impellizzieri², Alexander Vogetseder³, Przemyslaw Blyszczuk¹, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jörg Distler⁷, Gabriela Kania¹, Onur Boyman² and Oliver Distler⁸, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ³Department of Pathology, Cantonal Hospital Lucerne, Lucerne, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁸Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Fos-related antigen 2 (Fra-2) is a transcription factor belonging to the Fos family proteins which is part of the AP-1 transcription factor complex. We…