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Abstracts tagged "immune tolerance and uric acid"

  • Abstract Number: 2254 • ACR/ARHP Annual Meeting 2018

    Update of SEL-212 Phase 2 Clinical Data in Symptomatic Gout Patients: Svp-Rapamycin Combined with Pegadricase Mitigates Immunogenicity and Enables Sustained Reduction of Serum Uric Acid Levels, Low Rate of Gout Flares and Monthly Dosing

    Earl Sands1, Alan J. Kivitz2, Wesley DeHaan Ph.D.1, Lloyd Johnston1 and Takashi Kei Kishimoto1, 1Selecta Biosciences, Watertown, MA, 2Altoona Center for Clinical Research, Duncansville, PA

    Background/Purpose:  Pegylated uricases are promising therapies for the treatment of severe chronic gout, but are limited by their immunogenicity.  We have previously shown that synthetic…
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