Abstracts tagged "immune tolerance and rheumatoid arthritis"

Abstract Number: 2823 • ACR/ARHP Annual Meeting 2013
FLIP Deficiency In Dendritic Cells Promotes Spontaneous Inflammatory and Erosive Arthritis
Qi Quan Huang¹, Harris R. Perlman², Robert Birkett³, Renee E. Koessler¹, Syamal K. Datta⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ⁴Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: FLIP is an anti-apoptotic protein induced by chronic inflammation. In this study a mouse line with FLIP deleted in CD11c+ dendritic cells (DCs), that…