ACR Meeting Abstracts

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Abstracts tagged "immune response"

  • Abstract Number: 1294 • 2013 ACR/ARHP Annual Meeting

    Anti-Inflammatory Effect Of Resveratrol As a Dietary Supplement In An Antigen-Induced Arthritis Rat Model

    Romina R. Riveiro-Naveira1, Jesus Loureiro1, Alberto Centeno-Cortés2, Eduardo López-Peláez2, Carlos Vaamonde-García1, M. Noa Valcárcel-Ares1, Francisco J. Blanco3 and Maria J. López-Armada1, 1Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, 2Experimental Surgery Unit, CHU A Coruña, A Coruña, Spain, 3Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain

    Background/Purpose: Inflammatory cells like macrophages, lymphocytes and neutrophils in hyperplasic synovial tissue have been identified as key players in the onset and development of rheumatoid…
  • Abstract Number: 730 • 2013 ACR/ARHP Annual Meeting

    Cell-Mediated Immune Responses To Influenza and Herpesvirus Antigen Stimulation Are Conserved But Adversely Impacted By Immunosuppressive Therapy and Active Infection In Patients With Granulomatosis With Polyangiitis

    John McKinnon1, Robbie Mailliard2, Dawn McClemens-McBride3, Donald Jones3, Charles Rinaldo Jr.4 and Kathleen Maksimowicz-McKinnon5, 1Infectious Disease, Henry Ford Hospital, Detroit, MI, 2Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, 3Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Infectious Diseases and Microbiology, Pathology, University of Pittsburgh, Pittsburgh, PA, 5Rheumatology, Henry Ford Hospital, Detroit, MI

    Background/Purpose: Reactivation of chronic herpesvirus infections is not uncommon in immunosuppressed patients, including those with granulomatosis with polyangiitis (GPA).  The effects of GPA disease and…
  • Abstract Number: L17 • 2013 ACR/ARHP Annual Meeting

    Safety and Immunogenicity of Inactivated Varicella-Zoster Virus Vaccine in Adults with Autoimmune Disease

    Lawrence McAdam1, Michael Eberhardson2, William Grainger3, Kim Papp4, Stephen Hall5, Tina Sterling6, Jon Stek6, Lei Pang6, Yanli Zhao6, Ivan Chan6, Richard Haupt6, Janie Parrino6 and Jeffrey Silber6, 1Advanced Rheumatology, Infusion and Clinical Research Center, Thousand Oaks, CA, 2Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Neurological Physicians of Arizona, Gilbert, AZ, 4K. Papp Clinical Research,, Waterloo, ON, Canada, 5Emeritus Research, Malvern, Australia, 6Merck & Co., Inc., Whitehouse Station, NJ

    Background/Purpose: Patients with autoimmune diseases are often immunocompromised, resulting in higher incidence of HZ than in immunocompetent individuals with significant morbidity and occasional mortality from…
  • Abstract Number: 2684 • 2013 ACR/ARHP Annual Meeting

    Impact Of Anti-Rheumatic Treatment On Immunogenicity Of Pandemic H1N1 Influenza Vaccine In Patients With Arthritis

    Meliha C. Kapetanovic1, Lars-Erik Kristensen2, Tore Saxne3, Teodora Aktas4, Andreas Mörner4 and Pierre Geborek5, 1Dept of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden, 2Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Malmö, Sweden, 3Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, 4Vaccinology Unit, Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden., Vaccinology Unit, Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden., Solna, Sweden, 5Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    Impact of anti-rheumatic treatment on immunogenicity of pandemic H1N1 influenza vaccine in patients with arthritis Background/Purpose: An adjuvanted pandemic H1N1 influenza (pH1N1) vaccine (Pandemrix®) was…
  • Abstract Number: 2618 • 2012 ACR/ARHP Annual Meeting

    Lupus Disease Activity Severely Impairs Pandemic Influenza A/H1N1 Vaccine Immune Response in Patients without Therapy

    Eduardo F. Borba1, Sandra G. Pasoto1, Ana L. Calich1, Ricardo Fuller1, Vilma S.T. Viana1, Margareth Vendramini1, Joao Miraglia2, Maria A. Ishida3 and Eloisa Bonfa4, 1Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, 2Instituto Butantan, Fundação Butantan, São Paulo, Brazil, 3Instituto Adolfo Lutz, São Paulo, Brazil, 4Rheumatology Division, University of São Paulo, Sao Paulo, Brazil

    Background/Purpose: To determine the influence of disease activity without the effect of drugs in pandemic 2009 influenza A (H1N1) vaccine immune response in untreated systemic…
  • Abstract Number: 2452 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis-Associated PTPN22 Modulates Toll-Like Receptor-Mediated, Type 1 Interferon-Dependent Innate Immunoregulation

    Yaya Wang1, Stephanie Stanford2, Wenbo Zhou3, Jennifer L. Auger4, Genhong Cheng5, Amanda Campbell6, Fernanda M. Shoyama1, Henry H. Balfour Jr.7, Andrew C. Chan8, Bryce A. Binstadt4, Nunzio Bottini6 and Erik J. Peterson3, 1Department of Medicine, University of Minnesota, Minneapolis, MN, 2Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 3University of Minnesota, Minneapolis, MN, 4Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, 5University of California, Los Angeles, Los Angeles, CA, 6La Jolla Institute for Allergy and Immunology, La Jolla, CA, 7University of Minnesota, Minneapolis, 8Immunology, Genentech Inc, South San Francisco, CA

    Background/Purpose: A coding polymorphism (C1858T) in PTPN22 is strongly associated with risk of Rheumatoid Arthritis (RA) and other autoimmune diseases. PTPN22 encodes Lymphoid Phosphatase (Lyp);…
  • Abstract Number: 1185 • 2012 ACR/ARHP Annual Meeting

    Regulatory Role of 1, 25 Dihydroxyvitamin D3 in the Pathogenesis of Autoimmune Arthritis

    Siba P. Raychaudhuri1, Ananya Datta Mitra2, Anupam Mitra1, Christine Abria2 and Smriti K. Raychaudhuri2, 1Rheumatology, VA Sacramento Medical Center/UC Davis School of Medicine, Mather, CA, 2Rheumatology, VA Sacramento Medical Center, Mather, CA

    Background/Purpose: Fibroblast like synoviocytes (FLS) and T lymphocytes are considered as major effector cells in the pathogenesis of autoimmune arthritis (AA) such as rheumatoid arthritis…
  • Abstract Number: 1072 • 2012 ACR/ARHP Annual Meeting

    Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function

    Stefan Uderhardt1, Tobias Rothe1, Elisabeth Zinser2, Olga Oskolkova3, Martin Herrmann4, Alexander Steinkasserer5, Valery Bochkov3, Georg Schett6 and Gerhard Kronke1, 1Internal Medicine 3, University of Erlangen, Erlangen, Germany, 2University of Erlangen, Erlangen, Germany, 3Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 4Instiute for Immunology, PhD, Erlangen, Germany, 5Department of Immune Modulation at the Department of Dermatology, University Hospital Erlangen, Erlangen, Germany, 6Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: During inflammation and tissue damage, pathogens as well as dying cells are ingested by different phagocytes such as macrophages and dendritic cells. The uptake…
  • Abstract Number: 666 • 2012 ACR/ARHP Annual Meeting

    Leukadherin 1, a CR3 Mimetic, Negatively Regulates Toll Like Receptor (TLR) Dependent Inflammatory Responses via  Degradation of an Adaptor Protein

    Kristen Lee1, Joanne H. Reed2, Vineet Gupta3, Tejaskumar Patel2, Jill P. Buyon4 and Robert M. Clancy2, 1Rheumatology, NYU Langone Medical Center, New York, NY, 2Medicine, New York University School of Medicine, New York, NY, 3Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL 33136, U.S.A., Miami, FL, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Systemic Lupus Erythematosus is characterized by continuous and cyclic stimulation of the innate immune system by endogenous nucleic acids. Immune complexes of Ro60, ssRNA…
  • Abstract Number: 475 • 2012 ACR/ARHP Annual Meeting

    Immunologic Responsiveness in Patients with Juvenile Idiopathic Arthritis On Methotrexate and Etanercept: 23 Valent Pneumococcal Vaccination

    Ankur A. Kamdar1, Patricia C. Giclas2 and Barry L. Myones3, 1Rheumatology, University of Texas Medical School at Houston, Houston, TX, 2Pediatric Allergy and Immunology, National Jewish Health, Denver, CO, 3Pediatrics, Baylor College of Medicine, Houston, TX

    Background/Purpose: There is a paucity of data regarding response to vaccinations in patients with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX). It is also…
  • Abstract Number: 98 • 2012 ACR/ARHP Annual Meeting

    How to Assess Risks for Pulmonary Infection in Patients Receiving Immunosuppressive Treatment for Rheumatic Diseases? A Report From a Large-Scale Prospective Cohort Study

    Hayato Yamazaki1, Ryoko Sakai1, Ryuji Koike2, Yasunari Miyazaki3, Michi Tanaka1, Toshihiro Nanki1, Kaori Watanabe1, Shinsuke Yasuda4, Takashi Kurita5, Yuko Kaneko6, Yoshiya Tanaka7, Yasuhiko Nishioka8, Yoshinari Takasaki9, Kenji Nagasaka10, Koichi Amano11, Shigeto Tohma12, Makoto Dohi13, Takahiko Sugihara14, Haruhito Sugiyama15, Yasushi Kawaguchi16, Naohiko Inase17, Sae Ochi18, Hiroyuki Hagiyama19, Nobuyuki Miyasaka20 and Masayoshi Harigai21, 1Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan, 2Clinical Research Center, Tokyo Medical and Dental University, Tokyo, Japan, 3Department of Integrated Pulmonology, Tokyo Medical and Dental University, Tokyo, Japan, 4Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 5Department of Medicine II, Hokkaido University, Sapporo, Japan, 6Dept of Internal Medicine, Keio Univ School of Medicine, Tokyo, Japan, 7The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, 8Department of Respiratory Medicine & Rheumotology, The Univeristy of Tokushima Graduate School, Tokushima, Japan, 9Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 10Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 11Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan, 12Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan, 13Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 14Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 15Division of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan, 16Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 17Dept of Integrated Pulmonology, Tokyo Medical and Dental University, Tokyo, Japan, 18Department of Rheumatology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan, 19Department of Rheumatology, Yokohama-city Bay Red Cross Hospital, Yokohama, Japan, 20Department of Medicine and Rheumatology and Global Center of Excellence Program, Tokyo Medical and Dental University, Tokyo, Japan, 21Dept of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan

    Background/Purpose: Patients with rheumatic diseases given immunosuppressive therapy are susceptible to various types of infections, especially pulmonary infections that affect their vital prognosis. The aim…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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