Abstracts tagged "immune response and systemic lupus erythematosus (SLE)"

Abstract Number: 6 • 2018 ACR/ARHP Annual Meeting
Ro52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production
Margarita Ivanchenko¹, Susanna Brauner², Gudny Ella Thorlacius¹, Aurélie Ambrosi¹ and Marie Wahren-Herlenius¹, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Neuroimmunology Unit, Department of Clinical Neurosciences, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, Solna, Sweden
Background/Purpose: Systemic rheumatic diseases are characterized by abnormal B cell activation with autoantibody production and hypergammaglobulinemia. The autoantigen Ro52/SSA, also denoted TRIM21, is a major…
Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting
Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease
Melissa E. Munroe¹, Jourdan R. Anderson², Timothy F. Gross³, Laura L. Stunz⁴, Gail A. Bishop⁴ and Judith A. James⁵, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴The University of Iowa, Iowa City, IA, ⁵Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…
Abstract Number: 678 • 2012 ACR/ARHP Annual Meeting
Estrogen Modulation of ZAS3 Is Mediated Through Estrogen Receptor α: An Underlying Mechanism of Gender-Bias in Systemic Lupus Erythematosus?
Nicholas Young¹, Alexandra Friedman², Lai-Chu Wu² and Wael N. Jarjour³, ¹Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Global population data has indicated that post-pubertal females have decreased rates of infectious diseases when compared to male counterparts and preadolescent or postmenopausal females. …

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