ACR Meeting Abstracts

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Abstracts tagged "immune response"

  • Abstract Number: 71 • 2019 ACR/ARP Annual Meeting

    Inhibition of Nuclear Pore Export Ameliorates Lupus via Modulation of Plasma Cell Generation and Survival

    Javier Rangel-Moreno1, Maria de la luz Garcia-Hernandez 2, Teresa Owen 3, Jennifer Barnard 3, Bruce Goldman 3, Christopher Ritchlin 2, Douglas Widman 4, Savanna Gornisiewicz 4, Sharon Tamir 4 and Jennifer H Anolik 3, 1University of Rochester Medical center, Rochester, NY, 2Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, 3University of Rochester, Rochester, NY, 4Karyopharm Therapeutics, Newton, MA

    Background/Purpose: A major challenge in lupus is the elimination of autoreactive plasma cells, which amplify inflammation at peripheral sites via deposition of autoantibody-self antigen complexes.…
  • Abstract Number: 1561 • 2017 ACR/ARHP Annual Meeting

    Network Meta-Analysis of Targeted Immunomodulators in the Treatment of Biologic-NaïVe Psoriatic Arthritis

    Vibeke Strand1, M. Elaine Husni2, Rakesh Singh3, Keith Betts4, Yan Song5, Jenny Griffith3 and Arijit Ganguli3, 1Stanford University, Palo Alto, CA, 2Cleveland Clinic, Cleveland, OH, 3AbbVie Inc., North Chicago, IL, 4Analysis Group, Inc., Los Angeles, CA, 5Analysis Group, Inc., Boston, MA

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory condition characterized by peripheral arthritis and psoriatic skin lesions requiring therapies that control both skin and joint symptoms.…
  • Abstract Number: 1577 • 2017 ACR/ARHP Annual Meeting

    Deciphering the Role of the Tissue Microenvironment in Shaping the Immune Landscape in Psoriatic Arthritis

    Jin Hui Sherlynn Chan1, Ying Ying Leung2, Warren Fong2, Yi Wei Yeo2, Bhairav Paleja1, Liyun Lai1, Suzan Saidin1, Camillus Chua1, Sharifah Nur Hazirah1, Su Li Poh1, Andrea Hsiu Ling Low2 and Salvatore Albani1,3, 1SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 2Singapore General Hospital, Singapore, Singapore, 3KK Women's and Children's Hospital, Singapore, Singapore

    Background/Purpose: Psoriatic arthritis (PsA) occurs in a third of patients with psoriasis (Ps) and up to 30% of patients with PsA do not have an…
  • Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting

    An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis

    Jun Shimizu1, Takao Kubota2 and Noboru Suzuki3, 1Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2The Japan Self Defense Forces Central Hospital, Tokyo, Japan, 3Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan

    Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…
  • Abstract Number: 1785 • 2017 ACR/ARHP Annual Meeting

    Serious or Opportunistic Infections in Infants Born to Pregnant Women with Rheumatoid Arthritis and Treated with a Biologic Medication

    Christina D Chambers1, Diana L Johnson2, Yunjun Luo3, Ronghui Xu4 and Kenneth L Jones3, 1Pediatrics and Family Medicine and Public Health, University of California San Diego, La Jolla, CA, 2Department of Pediatrics, University of California, San Diego, La Jolla, CA, 3Pediatrics, University of California San Diego, La Jolla, CA, 4Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA

    Background/Purpose:   Use of biologic therapies for rheumatoid arthritis (RA) in pregnancy is common. There is theoretical concern that these medications could interfere with postnatal…
  • Abstract Number: 2396 • 2017 ACR/ARHP Annual Meeting

    Safety and Humoral and Cell-Mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis

    JungHee Koh1, Ji-Won Kim2, Seung-Ki Kwok3, Ji Hyeon Ju4 and Sung-Hwan Park5, 1Seochogu, Banpodaero, 222, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 3[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 5Kangnam St Mary's Hosp, Seoul, Korea, Republic of (South)

    Background/Purpose: To examine humoral and cellular immune responses induced by a live attenuated herpes zoster (HZ) vaccine in patients with rheumatoid arthritis (RA) compared with…
  • Abstract Number: 298 • 2017 ACR/ARHP Annual Meeting

    Anabasum (JBT-101) Enhances Resolution of Inflammation in Humans

    Madhur Motwani1, Fran Bennett1, Mark Tepper2, Barbara White2, Paul Norris3, Raymond MacAllister1, Charles Serhan3 and Derek Gilroy1, 1University College London, London, United Kingdom, 2Corbus Pharmaceuticals, Norwood, MA, 3Harvard Medical School, Cambridge, MA

    Background/Purpose:   Certain rheumatic diseases including systemic sclerosis (SSc) are characterized by chronic activation of innate immune responses, leading to excessive fibrosis.  A normal innate…
  • Abstract Number: 383 • 2017 ACR/ARHP Annual Meeting

    Immunogenicity of 13 Valent Pneumococcal Vaccine in Children with Lupus: Single Center Experience in South Texas

    Elissa Gonzalez, Joe Cole and Mark Gorelik, Pediatrics, Baylor College of Medicine/Children's Hospital of San Antonio, San Antonio, TX

    Background/Purpose: Pneumococcal vaccination is an important part of the care of pediatric and adult patients with systemic lupus erythematosus, and is recommended as a quality…
  • Abstract Number: 188 • 2016 ACR/ARHP Annual Meeting

    Responsiveness to X-Linked Toll-like Receptors Differs Between Mice with XY and XX Sex Chromosome Complement, Regardless of the Gonadal Sex

    Brandon Pham, Isela Valera and Ram R. Singh, UCLA, Los Angeles, CA

    Background/Purpose:  Males and females differ in mounting immune response to pathogens. Females appear immune privileged, mounting stronger immune response to pathogens and vaccination. While this…
  • Abstract Number: 401 • 2016 ACR/ARHP Annual Meeting

    Humoral Immune Response after a Booster Dose with Tdap in Children and Adolescents with Juvenile Idiopathic Arthritis on Anti-TNF and in Healthy Controls

    Aline Nicacio1, Octavio Peracchi2, Juliana Yamada3, Fernanda Spina3, Brunna Alvarenga3, Maria Isabel Pinto3 and Maria Teresa Terreri4, 1Pediatric Rheumatology Unit, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil, 2Pediatric Rheumatology, Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, 3Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, 4Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil

    Background/Purpose:  Pertussis cases have increased worldwide and knowledge on immune response after adult Tdap vaccine is scarce. This study evaluated the humoral immune response profile…
  • Abstract Number: 1839 • 2015 ACR/ARHP Annual Meeting

    Safety and Immunogenicity of Quadrivalent Human Papilloma Virus (qHPV) Vaccine (Gardasil®) in Systemic Lupus Erythematous (SLE), Phase I Trial Completion

    J. Patricia Dhar1,2, Lynnette Essenmacher3, Renee Dhar4, Ardella Magee5, Joel Ager6 and Robert Sokol7, 1Internal Medicine, Wayne State University, Detroit, MI, 2Internal Medicine, Central Michigan University College of Medicine, Saginaw, MI, 3Wayne State University School of Medicine, Detroit, MI, 4CMED medical student, Central Michigan University College of Medicine, Mt. Pleasant, MI, 5Clinical and Translational Research Center, Wayne State University, Detroit, MI, 6Family Medicine, Wayne State University School of Medicine, Detroit, MI, 7Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI

    Background/Purpose: Women with SLE are at increased risk for HPV-related cervical disease. The qHPV vaccine immunizes and is protective against HPV types that cause the…
  • Abstract Number: 2429 • 2015 ACR/ARHP Annual Meeting

    Varicella Vaccination in Patients with Pediatric Rheumatic Diseases Receiving Immunosuppression: Proposal of a Pre-Vaccination Checklist to Ensure Safety

    Fabian Speth1, Johannes Peter Haas1, Susanne Loeber1 and Claas Hinze2, 1German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, 2Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany

    Background/Purpose: Varicella zoster virus (VZV) infection is a serious preventable infection in patients (pts) receiving immunosuppression (IS). The purpose of this study was to determine…
  • Abstract Number: 1744 • 2014 ACR/ARHP Annual Meeting

    CD4+ T Cell Subpopulations in Blood and Synovial Fluid Defined By Differential Expression of Integrins

    Deepak A. Rao1, Adam Chicoine2, Peter A. Nigrovic3, Soumya Raychaudhuri4, Michael B. Brenner5 and ACR Authors 2014, 1Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital/Harvard University, Cambridge, MA, 4Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 5Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose CD4+ T cells are important mediators of inflammation in rheumatoid arthritis; however, the specific CD4+ T cell populations most important in driving disease pathology…
  • Abstract Number: 2684 • 2013 ACR/ARHP Annual Meeting

    Impact Of Anti-Rheumatic Treatment On Immunogenicity Of Pandemic H1N1 Influenza Vaccine In Patients With Arthritis

    Meliha C. Kapetanovic1, Lars-Erik Kristensen2, Tore Saxne3, Teodora Aktas4, Andreas Mörner4 and Pierre Geborek5, 1Dept of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden, 2Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Malmö, Sweden, 3Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, 4Vaccinology Unit, Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden., Vaccinology Unit, Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden., Solna, Sweden, 5Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    Impact of anti-rheumatic treatment on immunogenicity of pandemic H1N1 influenza vaccine in patients with arthritis Background/Purpose: An adjuvanted pandemic H1N1 influenza (pH1N1) vaccine (Pandemrix®) was…
  • Abstract Number: 2167 • 2013 ACR/ARHP Annual Meeting

    23-Valent Polysaccharide Pneumococcal Vaccine in Juvenile Idiopathic Arthritis Patients: Anti-Tumor Necrosis Factor Therapy Role in Short and Long-Term Immunogenicity

    Nadia E. Aikawa1, Ivan L.A. França2, Ana C. M. Ribeiro3, Adriana M. Sallum4, Eloisa Bonfa5 and Clovis A. Silva4, 1Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 2Division of Infectious Diseases, University of São Paulo, São Paulo, Brazil, 3Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, 5Rheumatology Division, University of São Paulo, Sao Paulo, Brazil

    Background/Purpose: There is no study regarding short and long-term assessments of 23-valent polysaccharide pneumococcal vaccine (PPV23) in juvenile idiopathic arthritis (JIA) under biologic therapy. The objectives…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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