Abstracts tagged "immune response"

Abstract Number: 71 • 2019 ACR/ARP Annual Meeting
Inhibition of Nuclear Pore Export Ameliorates Lupus via Modulation of Plasma Cell Generation and Survival
Javier Rangel-Moreno¹, Maria de la luz Garcia-Hernandez ², Teresa Owen ³, Jennifer Barnard ³, Bruce Goldman ³, Christopher Ritchlin ², Douglas Widman ⁴, Savanna Gornisiewicz ⁴, Sharon Tamir ⁴ and Jennifer H Anolik ³, ¹University of Rochester Medical center, Rochester, NY, ²Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ³University of Rochester, Rochester, NY, ⁴Karyopharm Therapeutics, Newton, MA
Background/Purpose: A major challenge in lupus is the elimination of autoreactive plasma cells, which amplify inflammation at peripheral sites via deposition of autoantibody-self antigen complexes.…
Abstract Number: 298 • 2017 ACR/ARHP Annual Meeting
Anabasum (JBT-101) Enhances Resolution of Inflammation in Humans
Madhur Motwani¹, Fran Bennett¹, Mark Tepper², Barbara White², Paul Norris³, Raymond MacAllister¹, Charles Serhan³ and Derek Gilroy¹, ¹University College London, London, United Kingdom, ²Corbus Pharmaceuticals, Norwood, MA, ³Harvard Medical School, Cambridge, MA
Background/Purpose: Certain rheumatic diseases including systemic sclerosis (SSc) are characterized by chronic activation of innate immune responses, leading to excessive fibrosis. A normal innate…
Abstract Number: 383 • 2017 ACR/ARHP Annual Meeting
Immunogenicity of 13 Valent Pneumococcal Vaccine in Children with Lupus: Single Center Experience in South Texas
Elissa Gonzalez, Joe Cole and Mark Gorelik, Pediatrics, Baylor College of Medicine/Children's Hospital of San Antonio, San Antonio, TX
Background/Purpose: Pneumococcal vaccination is an important part of the care of pediatric and adult patients with systemic lupus erythematosus, and is recommended as a quality…
Abstract Number: 1561 • 2017 ACR/ARHP Annual Meeting
Network Meta-Analysis of Targeted Immunomodulators in the Treatment of Biologic-NaïVe Psoriatic Arthritis
Vibeke Strand¹, M. Elaine Husni², Rakesh Singh³, Keith Betts⁴, Yan Song⁵, Jenny Griffith³ and Arijit Ganguli³, ¹Stanford University, Palo Alto, CA, ²Cleveland Clinic, Cleveland, OH, ³AbbVie Inc., North Chicago, IL, ⁴Analysis Group, Inc., Los Angeles, CA, ⁵Analysis Group, Inc., Boston, MA
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory condition characterized by peripheral arthritis and psoriatic skin lesions requiring therapies that control both skin and joint symptoms.…
Abstract Number: 1577 • 2017 ACR/ARHP Annual Meeting
Deciphering the Role of the Tissue Microenvironment in Shaping the Immune Landscape in Psoriatic Arthritis
Jin Hui Sherlynn Chan¹, Ying Ying Leung², Warren Fong², Yi Wei Yeo², Bhairav Paleja¹, Liyun Lai¹, Suzan Saidin¹, Camillus Chua¹, Sharifah Nur Hazirah¹, Su Li Poh¹, Andrea Hsiu Ling Low² and Salvatore Albani^1,3, ¹SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²Singapore General Hospital, Singapore, Singapore, ³KK Women's and Children's Hospital, Singapore, Singapore
Background/Purpose: Psoriatic arthritis (PsA) occurs in a third of patients with psoriasis (Ps) and up to 30% of patients with PsA do not have an…
Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting
An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis
Jun Shimizu¹, Takao Kubota² and Noboru Suzuki³, ¹Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²The Japan Self Defense Forces Central Hospital, Tokyo, Japan, ³Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan
Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…
Abstract Number: 1785 • 2017 ACR/ARHP Annual Meeting
Serious or Opportunistic Infections in Infants Born to Pregnant Women with Rheumatoid Arthritis and Treated with a Biologic Medication
Christina D Chambers¹, Diana L Johnson², Yunjun Luo³, Ronghui Xu⁴ and Kenneth L Jones³, ¹Pediatrics and Family Medicine and Public Health, University of California San Diego, La Jolla, CA, ²Department of Pediatrics, University of California, San Diego, La Jolla, CA, ³Pediatrics, University of California San Diego, La Jolla, CA, ⁴Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA
Background/Purpose: Use of biologic therapies for rheumatoid arthritis (RA) in pregnancy is common. There is theoretical concern that these medications could interfere with postnatal…
Abstract Number: 2396 • 2017 ACR/ARHP Annual Meeting
Safety and Humoral and Cell-Mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis
JungHee Koh¹, Ji-Won Kim², Seung-Ki Kwok³, Ji Hyeon Ju⁴ and Sung-Hwan Park⁵, ¹Seochogu, Banpodaero, 222, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵Kangnam St Mary's Hosp, Seoul, Korea, Republic of (South)
Background/Purpose: To examine humoral and cellular immune responses induced by a live attenuated herpes zoster (HZ) vaccine in patients with rheumatoid arthritis (RA) compared with…
Abstract Number: 188 • 2016 ACR/ARHP Annual Meeting
Responsiveness to X-Linked Toll-like Receptors Differs Between Mice with XY and XX Sex Chromosome Complement, Regardless of the Gonadal Sex
Brandon Pham, Isela Valera and Ram R. Singh, UCLA, Los Angeles, CA
Background/Purpose: Males and females differ in mounting immune response to pathogens. Females appear immune privileged, mounting stronger immune response to pathogens and vaccination. While this…
Abstract Number: 401 • 2016 ACR/ARHP Annual Meeting
Humoral Immune Response after a Booster Dose with Tdap in Children and Adolescents with Juvenile Idiopathic Arthritis on Anti-TNF and in Healthy Controls
Aline Nicacio¹, Octavio Peracchi², Juliana Yamada³, Fernanda Spina³, Brunna Alvarenga³, Maria Isabel Pinto³ and Maria Teresa Terreri⁴, ¹Pediatric Rheumatology Unit, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil, ²Pediatric Rheumatology, Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, ³Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, ⁴Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil
Background/Purpose: Pertussis cases have increased worldwide and knowledge on immune response after adult Tdap vaccine is scarce. This study evaluated the humoral immune response profile…
Abstract Number: 1839 • 2015 ACR/ARHP Annual Meeting
Safety and Immunogenicity of Quadrivalent Human Papilloma Virus (qHPV) Vaccine (Gardasil®) in Systemic Lupus Erythematous (SLE), Phase I Trial Completion
J. Patricia Dhar^1,2, Lynnette Essenmacher³, Renee Dhar⁴, Ardella Magee⁵, Joel Ager⁶ and Robert Sokol⁷, ¹Internal Medicine, Wayne State University, Detroit, MI, ²Internal Medicine, Central Michigan University College of Medicine, Saginaw, MI, ³Wayne State University School of Medicine, Detroit, MI, ⁴CMED medical student, Central Michigan University College of Medicine, Mt. Pleasant, MI, ⁵Clinical and Translational Research Center, Wayne State University, Detroit, MI, ⁶Family Medicine, Wayne State University School of Medicine, Detroit, MI, ⁷Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI
Background/Purpose: Women with SLE are at increased risk for HPV-related cervical disease. The qHPV vaccine immunizes and is protective against HPV types that cause the…
Abstract Number: 2429 • 2015 ACR/ARHP Annual Meeting
Varicella Vaccination in Patients with Pediatric Rheumatic Diseases Receiving Immunosuppression: Proposal of a Pre-Vaccination Checklist to Ensure Safety
Fabian Speth¹, Johannes Peter Haas¹, Susanne Loeber¹ and Claas Hinze², ¹German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ²Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany
Background/Purpose: Varicella zoster virus (VZV) infection is a serious preventable infection in patients (pts) receiving immunosuppression (IS). The purpose of this study was to determine…
Abstract Number: 1744 • 2014 ACR/ARHP Annual Meeting
CD4+ T Cell Subpopulations in Blood and Synovial Fluid Defined By Differential Expression of Integrins
Deepak A. Rao¹, Adam Chicoine², Peter A. Nigrovic³, Soumya Raychaudhuri⁴, Michael B. Brenner⁵ and ACR Authors 2014, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard University, Cambridge, MA, ⁴Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁵Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose CD4+ T cells are important mediators of inflammation in rheumatoid arthritis; however, the specific CD4+ T cell populations most important in driving disease pathology…
Abstract Number: L17 • 2013 ACR/ARHP Annual Meeting
Safety and Immunogenicity of Inactivated Varicella-Zoster Virus Vaccine in Adults with Autoimmune Disease
Lawrence McAdam¹, Michael Eberhardson², William Grainger³, Kim Papp⁴, Stephen Hall⁵, Tina Sterling⁶, Jon Stek⁶, Lei Pang⁶, Yanli Zhao⁶, Ivan Chan⁶, Richard Haupt⁶, Janie Parrino⁶ and Jeffrey Silber⁶, ¹Advanced Rheumatology, Infusion and Clinical Research Center, Thousand Oaks, CA, ²Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Neurological Physicians of Arizona, Gilbert, AZ, ⁴K. Papp Clinical Research,, Waterloo, ON, Canada, ⁵Emeritus Research, Malvern, Australia, ⁶Merck & Co., Inc., Whitehouse Station, NJ
Background/Purpose: Patients with autoimmune diseases are often immunocompromised, resulting in higher incidence of HZ than in immunocompetent individuals with significant morbidity and occasional mortality from…
Abstract Number: 2684 • 2013 ACR/ARHP Annual Meeting
Impact Of Anti-Rheumatic Treatment On Immunogenicity Of Pandemic H1N1 Influenza Vaccine In Patients With Arthritis
Meliha C. Kapetanovic¹, Lars-Erik Kristensen², Tore Saxne³, Teodora Aktas⁴, Andreas Mörner⁴ and Pierre Geborek⁵, ¹Dept of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden, ²Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Malmö, Sweden, ³Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, ⁴Vaccinology Unit, Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden., Vaccinology Unit, Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden., Solna, Sweden, ⁵Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
Impact of anti-rheumatic treatment on immunogenicity of pandemic H1N1 influenza vaccine in patients with arthritis Background/Purpose: An adjuvanted pandemic H1N1 influenza (pH1N1) vaccine (Pandemrix®) was…

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