Abstracts tagged "immune-related adverse events"

Abstract Number: 1516 • ACR Convergence 2021
Clinical Phenotypes and Treatment of Rheumatic Immune-Related Adverse Events from Checkpoint Inhibitors: A Retrospective Cohort of 112 Patients
Tiphaine Lenfant¹, Yuxuan Jin², Elizabeth Kirchner³, Pauline Funchain², Jung-Min Song², Moshe Ornstein², Laura Wood², Donald Eicher², Rula Hajj-Ali⁴, Leonard Calabrese² and Cassandra Calabrese⁵, ¹Institut Mutualiste Montsouris, Paris, France, ²Cleveland Clinic, Cleveland, OH, ³CCF, Cleveland, OH, ⁴Cleveland Clinic, Hunting Valley, OH, ⁵Cleveland Clinic Foundation, Cleveland Heights, OH
Background/Purpose: To describe a single center cohort of rheumatic immune related adverse events (irAEs) observed in patients treated with checkpoint inhibitor therapy (ICI) and to…
Abstract Number: 1519 • ACR Convergence 2021
Concomitant Targeted Therapy with Ongoing Immune Checkpoint Inhibitor (ICI) Therapy for Severe Immune Related Adverse Events (irAEs): Clinical Experience from Two Centers
Cassandra Calabrese¹, Khashayar Esfahani² and Leonard Calabrese³, ¹Cleveland Clinic Foundation, Cleveland Heights, OH, ²Jewish General Hospital, Department of Oncology, McGill University, Montréal, QC, Canada, ³Cleveland Clinic, Cleveland, OH
Background/Purpose: Treatment of irAEs is a balance of suppressing irAE-associated hyper-inflammation without inhibiting anti-tumoral effects of ICI. Treatment of grade 3/4 irAEs is most challenging…
Abstract Number: 1520 • ACR Convergence 2021
Do Specific Rheumatic Autoantibodies Predict Severity or Time to Onset of Immune-related Adverse Events from Checkpoint Inhibitors?
Nilasha Ghosh¹, Deanna Jannat-Khah², Karmela Kim Chan², Michael Postow³ and Anne Bass⁴, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Memorial Sloane Kettering Cancer Center, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Immune checkpoint inhibitors (ICI) are a novel cancer therapeutic that have had a dramatic impact on treating advanced malignancies by enhancing the anti-tumor T…
Abstract Number: 1521 • ACR Convergence 2021
Autoantibody Microarray Signal Intensities May Predict the Occurrence of Immune-related Adverse Events
Nilasha Ghosh¹, Chengsong Zhu², Karmela Kim Chan³, Michael Postow⁴ and Anne Bass⁵, ¹Hospital for Special Surgery, New York, NY, ²UT Southwestern, Dallas, TX, ³Hospital for Special Surgery, New York, NY, ⁴Memorial Sloane Kettering Cancer Center, New York, NY, ⁵Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Immune checkpoint inhibitors (ICI) are a novel cancer therapeutic that have had a dramatic impact on treating advanced malignancies by enhancing the anti-tumor T…
Abstract Number: 2138 • ACR/ARP Annual Meeting 2019
Rheumatic Immune-related Adverse Effects from Checkpoint Inhibitor Immunotherapy in Patients with Solid Tumors in a Latin American Population
Alain Sánchez-Rodríguez¹, Elina Alexandra Rodriguez-Melendez ², Alonso Turrent-Carriles ³, Paola Bermúdez-Bermejo ³, josé Fabián Martínez-Herrera ² and Raquel Gerson-Cwilich ², ¹Hospital General de Mexico, Mexico City, Distrito Federal, Mexico, ²ABC Medical Center, Oncology Department, Ciudad de Mexico, Distrito Federal, Mexico, ³ABC Medical Center, Rheumatology Department, Ciudad de Mexico, Distrito Federal, Mexico
Background/Purpose: Cancer immunotherapy is a newly-approved approach in the management of advanced malignancies. Immune checkpoint inhibitors (ICIs) are the most commonly used type of cancer…