Abstracts tagged "Immune Dysregulation and auto-immunity"

Abstract Number: 15 • 2018 ACR/ARHP Annual Meeting
Abnormal ZAP-70 Expression in B Cells: New Potential Role in Tolerance Breakdown
Mickaël Martin¹, Anne-marie KNAPP¹, Dana GHERGUS¹, Fabien DELMOTTE², Laurent Vallat³, Cédric SCHLEISS³, Raoul HERBRECHT⁴, Anne-sophie KORGANOW¹, Frédéric GROS¹, Sophie JUNG¹, Pauline SOULAS-SPRAUEL¹, Eric Meffre² and Thierry Martin⁵, ¹CNRS UPR 3572 "Immunopathology and Therapeutic Chemistry"/Laboratory of Excellence Medalis, Institute of Molecular and Cellular Biology (IBMC), STRASBOURG, France, ²Department of Immunobiology, Yale University School of Medicine, NEW HAVEN, CT, ³Laboratoire d'hematologie, Hopital Hautepierre, STRASBOURG, France, ⁴Service d'Hématologie et Oncologie, Hôpitaux universitaires de Strasbourg, STRASBOURG, France, ⁵CNRS UPR 3572 "Immunopathology and Therapeutic Chemistry"/Laboratory of Excellence Medalis, Institute of Molecular and Cellular Biology (IBMC), STRSBOURG, France
Background/Purpose: Abnormal expression of the tyrosine kinase ZAP-70 by tumoral B cells in chronic lymphocytic leukemia (CLL) is associated with B cell receptor (BCR) hypersignalling…

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